鸡胫长和胫围的全基因组关联分析

Abstract

Abstract:

To reveal genetic basis and molecular mechanism affecting shank growth in chicken, live weight, shank length and shank girth of F₂ generation individuals were measured at 93-day-old, these birds came from Chinese Academy of Agricultural Sciences (CAAS) chicken F₂ rescoure population. Genomic DNA was genotyped using chicken 60 K SNP Beadchip. The genome-wide association study (GWAS) on shank length and shank girth were performed. The results showed that 1 and 4 SNPs were significantly associated with shank length and girth (P<2.98×10^-6), respectively at 5% genome-wide level; 4 and 25 SNPs were suggestive associatied with the two traits (P<5.96×10^-5), respectively. SNPs located at downstream of NKX2-5 and ELAVL4 on chromosome 13 and 8 were signficantly associated with shank length and girth, respectively at 5% genome-wide level. Many SNPs associated with shank length were in 14.93 Mb region (71.01-85.94 Mb) on chromosome 4, and LDB2, BOD1L1 and QDPR were in this region. These genes and regions could be important candidate genes and regions for shank length and girth. The results lay a foundation for revealing the genetic basis and molecular mechanism for shank growth and marker assisted selection in the further.

CLC Number:

S831.2

SUN Yan-fa, LIU Ran-ran, ZHENG Mai-qing, ZHAO Gui-ping, ZHANG Lei, WU Dan, HU Yao-dong, LI Peng, WEN Jie. Genome-wide Association Study on Shank Length and Shank Girth in Chicken[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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Genome-wide Association Study on Shank Length and Shank Girth in Chicken

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