Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (8): 3152-3163.doi: 10.11843/j.issn.0366-6964.2023.08.003

• REVIEW • Previous Articles     Next Articles

Research Progress of Key Regulatory Gene DMRT1 in Chicken Sex Determination and Differentiation

ZHENG Gang, LIAN Ling*   

  1. Laboratory of Animal Genetic Resources and Molecular Breeding, China Agricultural University, Beijing 100193, China
  • Received:2022-12-30 Online:2023-08-23 Published:2023-08-22

Abstract: Chicken is one of important agricultural animals and the eggs they supplied are a high quality and economical source of animal protein. In the layer industry,the early sex identification is indispensable procedure due to the preference for female chicks. Large numbers of male chicks were culled after sex identification,which not only causes a huge loss but also has ethical issues. In recent years,the development of science and technology has made it possible to artificially control the sex of livestock and poultry. The research on sex regulation mechanisms has excavated many important candidate genes,among which the DMRT1 gene is considered to be a key gene in the regulation of gonad formation in roosters. This paper reviewed the role of the DMRT1 gene in chicken sex determination and gonadal differentiation as well as the related pathways and the potential factors affecting its expression. This review provides a reference for in-depth studies on the mechanism of sex determination and development of feasible artificial sex control approaches.

Key words: DMRT1, chicken embryo, sex determination, gonadogenesis

CLC Number: