Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (8): 3152-3163.doi: 10.11843/j.issn.0366-6964.2023.08.003
• REVIEW • Previous Articles Next Articles
ZHENG Gang, LIAN Ling*
Received:
2022-12-30
Online:
2023-08-23
Published:
2023-08-22
CLC Number:
ZHENG Gang, LIAN Ling. Research Progress of Key Regulatory Gene DMRT1 in Chicken Sex Determination and Differentiation[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3152-3163.
[1] | KRAUTWALD-JUNGHANNS M E, CRAMER K, FISCHER B, et al.Current approaches to avoid the culling of day-old male chicks in the layer industry, with special reference to spectroscopic methods[J].Poult Sci, 2018, 97(3):749-757. |
[2] | ZHANG W, PAN L Q, TU K, et al.Comparison of spectral and image morphological analysis for egg early hatching property detection based on hyperspectral imaging[J].PLoS One, 2014, 9(2):e88659. |
[3] | 宋 科, 韩 璐, 杨崇龙, 等.鸡胚性别鉴定方法研究进展[J].中国家禽, 2022, 44(10):101-107.SONG K, HAN L, YANG C L, et al.Research progress on methods for sex identification of chick embryos[J].China Poultry, 2022, 44(10):101-107.(in Chinese) |
[4] | DOUGLAS C, TURNER J M A.Advances and challenges in genetic technologies to produce single-sex litters[J].PLoS Genet, 2020, 16(7):e1008898. |
[5] | KOOPMAN P, GUBBAY J, VIVIAN N, et al.Male development of chromosomally female mice transgenic for SRY[J].Nature, 1991, 351(6322):117-121. |
[6] | KOBAYASHI K, KITANO T, IWAO Y, et al.Reproductive and developmental strategies:the continuity of life[M].Tokyo:Springer, 2018:391-405. |
[7] | SMITH C A.Sex determination in birds:HINT s from the W sex chromosome?[J].Sex Dev, 2007, 1(5):279-285. |
[8] | SMITH C A, ROESZLER K N, HUDSON Q J, et al.Avian sex determination:what, when and where?[J].Cytogenet Genome Res, 2007, 117(1-4):165-173. |
[9] | SUN C H, JIN K, ZHOU J, et al.Role and function of the Hintw in early sex differentiation in chicken (Gallus gallus) embryo[J]. Anim Biotechnol, 2023, 34(1):56-66. |
[10] | SHAW D L, CARSIENCE R S, ETCHES R J, et al.The fate of female donor blastodermal cells in male chimeric chickens[J]. Biochem Cell Biol, 1992, 70(10-11):1218-1229. |
[11] | LIN M, THORNE M H, MARTIN I C, et al.Development of the gonads in the triploid (ZZW and ZZZ) fowl, Gallus domesticus, and comparison with normal diploid males (ZZ) and females (ZW)[J].Reprod Fertil Dev, 1995, 7(5):1185-1197. |
[12] | ZHAO D, MCBRIDE D, NANDI S, et al.Somatic sex identity is cell autonomous in the chicken[J].Nature, 2010, 464(7286):237-242. |
[13] | CLINTON M, ZHAO D, NANDI S, et al.Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process?[J].Chromosome Res, 2012, 20(1):177-190. |
[14] | CAPEL B.Vertebrate sex determination:evolutionary plasticity of a fundamental switch[J].Nat Rev Genet, 2017, 18(11):675-689. |
[15] | KOOPMAN P.The genetics and biology of vertebrate sex determination[J].Cell, 2001, 105(7):843-847. |
[16] | ESTERMANN M A, WILLIAMS S, HIRST C E, et al.Insights into gonadal sex differentiation provided by single-cell transcriptomics in the chicken embryo[J].Cell Rep, 2020, 31(1):107491. |
[17] | SMITH C A, SINCLAIR A H.Sex determination:insights from the chicken[J].Bioessays, 2004, 26(2):120-132. |
[18] | YOSHINO T, MURAI H, SAITO D.Hedgehog-BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos[J].Nat Commun, 2016, 7:12561. |
[19] | HA Y, TSUKADA A, SAITO N, et al.Identification of differentially expressed genes involved in the regression and development of the chicken Müllerian duct[J].Int J Dev Biol, 2008, 52(8):1135-1141. |
[20] | FERGUSON-SMITH M.The evolution of sex chromosomes and sex determination in vertebrates and the key role of DMRT1[J]. Sex Dev, 2007, 1(1):2-11. |
[21] | SMITH C A, MCCLIVE P J, WESTERN P S, et al.Conservation of a sex-determining gene[J].Nature, 1999, 402(6762):601-602. |
[22] | ZARKOWER D, MURPHY M W.DMRT1:an ancient sexual regulator required for human gonadogenesis[J].Sex Dev, 2022, 16(2-3):112-125. |
[23] | OMOTEHARA T, SMITH C A, MANTANI Y, et al.Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Müllerian ducts[J].Poult Sci, 2014, 93(4):953-958. |
[24] | SHAN Z, NANDA I, WANG Y, et al.Sex-specific expression of an evolutionarily conserved male regulatory gene, DMRT1, in birds[J].Cytogenet Cell Genet, 2000, 89(3-4):252-257. |
[25] | AYERS K L, CUTTING A D, ROESZLER K N, et al.DMRT1 is required for Müllerian duct formation in the chicken embryo[J]. Dev Biol, 2015, 400(2):224-236. |
[26] | IOANNIDIS J, TAYLOR G, ZHAO D B, et al.Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics[J].Proc Natl Acad Sci U S A, 2021, 118(10):e2020909118. |
[27] | OMOTEHARA T, MINAMI K, MANTANI Y, et al.Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo[J].Dev Dyn, 2017, 246(2):148-156. |
[28] | RAYMOND C S, KETTLEWELL J R, HIRSCH B, et al.Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development[J].Dev Biol, 1999, 215(2):208-220. |
[29] | NANDA I, ZEND-AJUSCH E, SHAN Z, et al.Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1:a comparative (re)view on avian sex determination[J].Cytogenet Cell Genet, 2000, 89(1-2):67-78. |
[30] | ORÉAL E, MAZAUD S, PICARD J Y, et al.Different patterns of anti-Müllerian hormone expression, as related to DMRT1, SF-1, WT1, GATA-4, Wnt-4, and Lhx9 expression, in the chick differentiating gonads[J].Dev Dyn, 2002, 225(3):221-232. |
[31] | YAMAMOTO I, TSUKADA A, SAITO N, et al.Profiles of mRNA expression of genes related to sex differentiation of the gonads in the chicken embryo[J].Poult Sci, 2003, 82(9):1462-1467. |
[32] | SMITH C A, KATZ M, SINCLAIR A H.DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos[J].Biol Reprod, 2003, 68(2):560-570. |
[33] | 郑江霞, 杨 宁.鸟类性别决定候选基因在性反转鸡胚中的表达[J].遗传, 2007, 29(1):81-86.ZHENG J X, YANG N.mRNA expression of genes related to avian sex determination during female-to-male sex reversal in ZW chicken embryos[J].Hereditas (Beijing), 2007, 29(1):81-86.(in Chinese) |
[34] | SMITH C A, ROESZLER K N, OHNESORG T, et al.The avian Z-linked gene DMRT1 is required for male sex determination in the chicken[J].Nature, 2009, 461(7261):267-271. |
[35] | LAMBETH L S, CUMMINS D M, DORAN T J, et al.Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos[J].PLoS One, 2013, 8(6):e68362. |
[36] | FANG L X, XIN R, CHE Y, et al.Expression of sex-related genes in chicken embryos during male-to-female sex reversal exposure to diethylstilbestrol[J].J Integr Agric, 2013, 12(1):127-135. |
[37] | LAMBETH L S, RAYMOND C S, ROESZLER K N, et al.Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads[J].Dev Biol, 2014, 389(2):160-172. |
[38] | HIRST C E, MAJOR A T, AYERS K L, et al.Sex reversal and comparative data undermine the w chromosome and support Z-linked DMRT1 as the regulator of gonadal sex differentiation in birds[J].Endocrinology, 2017, 158(9):2970-2987. |
[39] | LEE H J, SEO M, CHOI H J, et al.DMRT1 gene disruption alone induces incomplete gonad feminization in chicken[J].FASEB J, 2021, 35(9):e21876. |
[40] | SÁNCHEZ L, CHAOUIYA C.Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads[J].J R Soc Interface, 2018, 15(142):20180165. |
[41] | HIRST C E, MAJOR A T, SMITH C A.Sex determination and gonadal sex differentiation in the chicken model[J].Int J Dev Biol, 2018, 62(1-3):153-166. |
[42] | MAJOR A T, AYERS K L, CHUE J, et al.FOXL2 antagonises the male developmental pathway in embryonic chicken gonads[J].J Endocrinol, 2019, 243(3):211-228. |
[43] | ESTERMANN MA, MAJOR A T, SMITH C A.Genetic regulation of avian testis development[J].Genes (Basel), 2021, 12(9):1459. |
[44] | MURPHY M W, SARVER A L, RICE D, et al.Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis[J].Proc Natl Acad Sci U S A, 2010, 107(30):13360-13365. |
[45] | LINDEMAN R E, MURPHY M W, AGRIMSON K S, et al.The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming[J].Nucleic Acids Res, 2021, 49(11):6144-6164. |
[46] | GAO S, ZHANG T, ZHOU X, et al.Molecular cloning, expression of SOX5 and its down-regulation of DMRT1 transcription in zebrafish[J].J Exp Zool B Mol Dev Evol, 2005, 304B(5):476-483. |
[47] | LEI N, KARPOVA T, HORNBAKER K I, et al.Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice[J].Biol Reprod, 2009, 81(1):118-125. |
[48] | TANG Y H, LI X Y, XIAO H S, et al.Transcription of the Sox30 gene is positively regulated by Dmrt1 in Nile Tilapia[J].Int J Mol Sci, 2019, 20(21):5487. |
[49] | WEI L, LI X Y, LI M H, et al.DMRT1 directly regulates the transcription of the testis-biased Sox9b gene in Nile tilapia (Oreochromis niloticus)[J]. Gene, 2019, 687:109-115. |
[50] | BANNISTER S C, SMITH C A, ROESZLER K N, et al.Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads[J].Biol Reprod, 2011, 85(1):22-30. |
[51] | CUTTING A D, BANNISTER S C, DORAN T J, et al.The potential role of microRNAs in regulating gonadal sex differentiation in the chicken embryo[J].Chromosome Res, 2012, 20(1):201-213. |
[52] | WARNEFORS M, MÖSSINGER K, HALBERT J, et al.Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation[J].Genome Res, 2017, 27(12):1961-1973. |
[53] | PRASTOWO S, RATRIYANTO A.miRNA target prediction of avian Z-linked DMRT1 gene during sex determination in chicken (G.gallus)[J].IOP Conf Ser Earth Environ Sci, 2021, 905(1):0120148. |
[54] | TERANISHI M, SHIMADA Y, HORI T, et al.Transcripts of the MHM region on the chicken Z chromosome accumulate as non-coding RNA in the nucleus of female cells adjacent to the DMRT1 locus[J].Chromosome Res, 2001, 9(2):147-165. |
[55] | ROESZLER K N, ITMAN C, SINCLAIR A H, et al.The long non-coding RNA, MHM, plays a role in chicken embryonic development, including gonadogenesis[J].Dev Biol, 2012, 366(2):317-326. |
[56] | YANG X R, ZHENG J X, XU G Y, et al.Exogenous cMHM regulates the expression of DMRT1 and ERα in avian testes[J].Mol Biol Rep, 2010, 37(4):1841-1847. |
[57] | CAETANO L C, GENNARO F G O, COELHO K, et al.Differential expression of the MHM region and of sex-determining-related genes during gonadal development in chicken embryos[J].Genet Mol Res, 2014, 13(1):838-849. |
[58] | SUN D, MANEY D L, LAYMAN T S, et al.Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system[J].Genome Res, 2019, 29(10):1673-1684. |
[59] | SHIODA K, ODAJIMA J, KOBAYASHI M, et al.Transcriptomic and epigenetic preservation of genetic sex identity in estrogen-feminized male chicken embryonic gonads[J].Endocrinology, 2021, 162(1):bqaa208. |
[60] | AYERS K L, DAVIDSON N M, DEMIYAH D, et al.RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome[J].Genome Biol, 2013, 14(3):R26. |
[61] | ICHIKAWA K, NAKAMURA Y, BONO H, et al.Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis[J].Sci Rep, 2022, 12(1):13528. |
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