非编码RNA调控哺乳动物子宫内膜容受性和蜕膜化的研究进展

doi:10.11843/j.issn.0366-6964.2023.04.001

Abstract

Abstract: Endometrial receptivity and decidualization are crucial parts of embryo implantation, which influenced the successful pregnancy and reproductive performance of mammalian. Therefore, it is of great significance to explore the regulatory mechanism of uterine physiological function to improve reproduction efficiency of female animals. Endometrial receptivity is an ability of the endometrium to allow blastocysts to localize, adhere, invade, and eventually implant. To transit into receptive state, the endometrium needs to undergo a series morphologically and functionally remodeling, during which endometrial stromal cells proliferate and differentiate into decidual cells, the process is called decidualization. Non-coding RNAs (ncRNAs) can affect a variety of physiological processes, including involvement in the regulation of endometrial function, and ceRNA network theories of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA are also important molecular mechanisms. In this review, the current research progresses of miRNA, lncRNA and circRNA in regulating mechanism of endometrial receptivity and decidualization were discussed, with a view to provide theoretical guidance and new ideas for further revealing mechanism of ncRNAs on the physiological function of mammalian uterus.

Key words: endometrial receptivity, decidualization, miRNA, lncRNA, circRNA, embryo implantation

CLC Number:

S814.1

QIN Xue, SHA Yiwen, YANG Menghao, CAI Rui, PANG Weijun. Advances in Regulation of Non-coding RNA on Mammalian Endometrial Receptivity and Decidualization[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1347-1358.

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Advances in Regulation of Non-coding RNA on Mammalian Endometrial Receptivity and Decidualization

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