m6A修饰调控circRNA的研究进展

doi:10.11843/j.issn.0366-6964.2023.10.002

Abstract

Abstract: Circular RNAs (circRNAs) are single-stranded, covalently closed RNA that were generated by 3' polyA and 5'tail of pre-mRNA via back-splicing. CircRNAs play a crucial role in varieties biological processes. N6-methyladenosine (m⁶A) is one of the most abundant modifications in eukaryotes, which regulate splicing, translation and degradation of RNA. There is increasing evidence that m⁶A modification also controlling circRNAs metabolism, including translation, degradation and so on. In this review, the biogenesis and function of circRNAs were summerized. Moreover, the role of m⁶A modification in the regulation of circRNAs was discussed.

Key words: circRNAs, function, m⁶A modification

CLC Number:

S811.3

YANG Zhimei, LIANG Chengcheng, ZHANG Dianqi, LI Xuefeng, ZAN Linsen. Research Progress on the Regulation of circRNA by m⁶A Modification[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4016-4027.

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Research Progress on the Regulation of circRNA by m⁶A Modification

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Research Progress on the Regulation of circRNA by m6A Modification

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Research Progress on the Regulation of circRNA by m⁶A Modification