Table 1

Groups and treatment of the experimental rabbits"

Fig. 1

Clinical signs and pathologic lesions of the rabbits A. Serosity nasal discharge of the infected rabbits; B. Purulent nasal discharge of the infected rabbits; C. No nasal discharge was observed in the control rabbits; D. Fibrinopurulent pleuropneumonia of the infected rabbits that were caught up in the endpoint of the experiment; E. Hemorrhagic pneumonia and pulmonary consolidation of the rabbits that survived the experiment; F. No pathologic lesions were observed in the lungs of control rabbits"

Fig. 2

Circular maps of the Pm3 and Pm6 genomes From the outside to the inside: circle 1 (black) shows the DNA base position; circle 2 and 3 (cyan-blue) show protein-coding regions in forward and reverse strands, respectively; circle 4 (red) shows the tRNA; circle 5 (green) shows the rRNA; circle 6 (blue) shows the genomic island; circle 7 (purple) shows the prophage sequence; the two innermost circles represent the G+C content and GC skew, respectively"

Fig. 3

Phylogenetic tree based on the 7 multi-locus sequence typing scheme housekeeping genes of P. multocida"

Fig. 4

Colinear analyses between the two strains (Pm3 and Pm6) and the low virulent (s4 and AH09) and high-virulent (PF1, PF2, PF11 and PF15) rabbit-sourced P. multocida strains"

Fig. 5

Comparative analysis of the genomes of Pm3 and Pm6 with the low-virulent (s4 and AH09) and high-virulent (PF1, PF2, PF11 and PF15) rabbit-sourced P. multocida strains From the outside to the inside: circle 1 (cyan-blue) represents s4; circle 2 (orange) represents AH09; circle 3 (gray) represents PF1; circle 4 (yellow) represents PF2; circle 5 (purple) represents PF11; circle 6 (green) represents PF15; circle 7 (blue) represents Pm3; circle 8 (red) represents Pm6; the three innermost circles represent the GC skew, G+C content and DNA base position, respectively"

Fig. 6

Specific genes identified in the genomes of Pm3 and Pm6 but not in the genomes of low-virulent rabbit-sourced P. multocida strains s4 and AH09"

Fig. 7

Comparative analyses of the entire cap locus between the two P. multocida strains (Pm3 and Pm6) and CQ2 (type A), s4 (type F) and HN06 (type D)"

Fig. 8

Comparative analyses of the natC gene from the P. multocida of LPS genotype L3 A. Represents the majority of P. multocida, such as the Pm70; B. Represents the HN07 (swine), F (bovine), 36502 (chicken) and SD11 (rabbit); C. Represents all of the rabbit-sourced P. multocida strains (except for SD11)"

Fig. 9

Comparative analyses of the gatF gene from the P. multocida of LPS genotype L3 A. Pm70; B. Represents some of the P. multocida strans, such as HN07 (swine), CQ6 (bovine), RCAD0726 (avian), CIRMBP-0873 (rabbit) and 9N (rodent); C. Represents some of the P. multocida strans, such as the P1933 (bovine), 36502 (avian) and SD11 (rabbit); D. Represents the F (bovine) and Pm-3 (bovine); E. Represents the CIRMBP-0884 (rabbit)"

Fig. 10

Comparative analyses of the LPS outer core locus between Pm6 and P1573"