基于蛋白质组学解析鹅肥肝形成的脂质代谢调控机制

doi:10.11843/j.issn.0366-6964.2025.05.018

Abstract

Abstract:

The study aimed to explore the molecular mechanism of foie gras formation, liver samples of Landes geese at 3 different feeding stages were analyzed by 4D-DIA quantitative proteomics. The 70-day-old Landes geese of the same batch with similar body condition were randomly selected and slaughtered at the early stage (7 d), middle stage (16 d) and final stage (25 d), 3 in each stage, respectively. The liver lobe and liver apex tissue samples were collected for 4D-DIA quantitative proteomic analysis. There were 3 groups with 3 biological replicates each. Result: 1) A total of 5 208 proteins were identified by comparison of the Landes geese liver at three different feeding stages. 2) Principal component analysis revealed significant differences in liver protein profiles across the 3 over-feeding stages, with 449 differential proteins identified in the comparison of early stage vs. middle stage, and 303 differential proteins identified in the comparison of middle stage vs. final stage. 3) Through pathway analysis of the differential metabolites, the enriched pathways were observed to be mainly involved in steroid hormone biosynthesis, ADIPOQ signaling pathway, amino sugar and nucleotide sugar metabolism, cysteine and methionine metabolism, arachidonic acid metabolism, and amino acid biosynthesis. The key differential genes ADIPOQ and PASK were identified based on RT-qPCR. The proteomic profile of liver of geese was significantly changed after over-feeding. The proteins related to steroid hormone biosynthesis and adipocytokine signaling pathway may be involved in the molecular regulation of foie gras formation.

Key words: foie gras, 4D-DIA quantitative proteomics, lipid metabolism, differential protein, molecular regulation mechanism

CLC Number:

S835.2

HOU Zhongyi, WANG Baowei, ZHANG Ming'ai, KONG Min, ZHANG Jing, WANG Binghan, YUE Bin, LU Xiu, FAN Wenlei. The Regulation Mechanism of Lipid Metabolism in Foie Gras Formation Based on Proteomics Analysis[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(5): 2182-2193.

Figures/Tables 8

Table 1

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基因 Gene	引物序列(5′→3′) Primer sequence
PASK	F: CGCGATGGCTGCTGAGG
	R: GACTCCTCGCCCATAGCTTC
ADIPOQ	F: ACCAGCCGCTAACAAGGG
	R: CTTGGTCGACGTTGTTGGTC
GAPDH	F: TCGGAGTCAACGGATTTGGC
	R: TTCTCAGCCTTGACTGTGCC

组别 Group	蛋白ID Protein ID	基因名 Gene name	蛋白功能描述 Protein function description	倍数变化 Fold change	P
下调 Down	A0A8B9DKQ2	CLDN20	Claudin	0.50	0.00
	A0A8B9DNV2	CD207	C-type lectin domain-containing protein	0.51	0.00
	A0A8B9DCX9	Romo1	Reactive oxygen species modulator 1	0.66	0.00
	A0A8B9DBW8	AMP1	AMP1 protein	0.15	0.00
	A0A8B9D2F8	Rv1747	ABC transporter domain-containing protein	0.48	0.00
	A0A8B9DI93	Cygb	Cytoglobin	0.60	0.00
	A0A8B9DKF8	PRUNE1	Prune exopolyphosphatase 1	0.65	0.00
	A0A8B9DPQ1	Siglec12	Ig-like domain-containing protein	0.60	0.00
	A0A8B9E544	ESP1	separase	0.50	0.00
	A0A8B9E3Q7	frvX	Aminopeptidase	0.66	0.00
上调 Up	A0A8B9E098	MARCHF5	S Mitochondrial fission regulator	1.88	0.00
	A0A8B9D9H9	Txlng	Taxilin gamma	1.57	0.00
	A0A8B9DSE6	TMED10	Transmembrane protein 263	2.27	0.00
	A0A8B9IND4	PAFAH2	Platelet-activating factor acetylhydrolase	2.82	0.00
	A0A8B9D8G3	LIAS	Lipoyl synthase	1.73	0.00
	A0A8B9DZ79	mid1ip1b	M1I1B protein	2.30	0.00
	A0A8B9EDG7	uppS	polycis-polyprenyl diphosphate synthase	3.10	0.00
	A0A8B9D5N3	UTP14A	U3 small nucleolar RNA-associated protein 14 homolog A	1.70	0.00
	A0A8B9E2N7	RB18B	RB18B protein	2.09	0.00
	A0A8B9DEC2	Cacybp	Calcyclin-binding protein	1.80	0.00

组别 Group	蛋白ID Protein ID	基因名 Gene name	蛋白功能描述 Protein function description	倍数变化 Fold change	P
下调Down	A0A8B9EM53		NADH: ubiquinone oxidoreductase core subunit V1	0.63	0.00
	A0A8B9E7E8	SC5D	Sterol-C5-desaturase	0.52	0.00
	A0A8B9ET89	Msed_0406	propionate--CoA ligase	0.54	0.00
	A0A8B9INS7	MT1H	Metallothionein	0.17	0.00
	A0A8B9DKF2	SEC61B	Protein transport protein Sec61 subunit beta	0.60	0.00
	A0A8B9D493	TMX3	thioredoxin-disulfide reductase	0.66	0.00
	A0A8B9EDT5	SYNE3	Spectrin repeat containing nuclear envelope family member 3	0.45	0.00
	A0A8B9EK56	PFKFB1	6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1	0.62	0.00
	A0A8B9E4B6	PASK	Protein kinase domain-containing protein	0.66	0.00
	A0A8B9INT0	TMEM41B	Transmembrane protein 177	0.35	0.00
上调 Up	A0A8B9D7K1	Plxnb2	Plexin B2	1.59	0.00
	A0A8B9D8Z5	Tacc1	Transforming acidic coiled-coil containing protein 2	2.05	0.00
	A0A8B9DGJ0	PDLIM4	PDZ and LIM domain 1	2.45	0.00
	A0A8B9DDN0	Urah	5-hydroxyisourate hydrolase	4.93	0.00
	A0A8B9DRG6	ADIPOQ	Adiponectin, C1Q and collagen domain containing	1.53	0.00
	A8B9DB57	CBX2	Chromobox 1	2.66	0.00
	A0A8B9DEL4	DEFB114	Beta-defensin 2	4.55	0.00
	B2ZR74	SSA1	Heat shock protein 70	1.61	0.00
	A0A8B9DD15	Cobl	Cordon-bleu WH2 repeat protein	1.98	0.00
	A0A8B9DMG4	ITSN1	Intersectin 1	1.52	0.00

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The Regulation Mechanism of Lipid Metabolism in Foie Gras Formation Based on Proteomics Analysis

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