肝脏-脂肪组织代谢串扰在围产期奶牛脂肪肝发展中的作用机制

doi:10.11843/j.issn.0366-6964.2023.10.010

Abstract

Abstract: The perinatal period is an important physiological stage of dairy cows, and it is also a period of frequent and high incidence of nutritional and metabolic diseases. Cows with severe negative energy balance will have peripheral tissue insulin resistance, which makes glucose are continuously transported to the mammary gland. However, the exacerbation of insulin resistance will lead to the disorder of the body's glucose and lipid metabolism, resulting in the excessive mobilization of adipose tissue and lipid accumulation in the liver, and in severe cases, fatty liver and other diseases. A large number of studies have shown that the crosstalk between liver and adipose tissue are closely related to the development of fatty liver. This review aims to summarize the factors and their effects in mediating liver-adipose tissue crosstalk, in order to provide scientific reference for regulating glucose and lipid metabolism and improving liver health of perinatal dairy cows.

Key words: periparturient cows, fatty liver, glucose and lipid metabolism, ceramide, adiponectin

CLC Number:

S852.2

ZHAO Huiying, YU Shiqiang, ZHAO Yuchao, JIANG Linshu. Mechanism of Liver-Adipose Tissue Crosstalk in the Development of Fatty Liver in Periparturient Cows[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4105-4116.

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Mechanism of Liver-Adipose Tissue Crosstalk in the Development of Fatty Liver in Periparturient Cows

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[1]	ZHANG Yafeng, ZHU Bin, MA Chang, ZHANG Yuanshu. The Research on the Effects of ACE2 Activated by Diminazene Aceturate on Mitochondria in the Liver of Rats with Non-alcoholic Fatty Liver Disease [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3895-3904.
[2]	ZHOU Min, WANG Kaige, ZHANG Lian, MA Xi. Advances in Microbiota-Gut-Muscle Axis Regulating Skeletal Muscle Metabolism and Function [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 2845-2857.
[3]	XIA Boce, ZHANG Kaiyi, MIAO Jiakun, PENG Huanqi, YANG Yu, TAO Cong, WU Tianwen, WANG Yanfang, YANG Shulin. Study on the mRNA Splicing Pattern Reshaped by the Nutritious Diet in Key Tissues of Metabolic Disease Susceptible Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2537-2547.
[4]	ZHANG Mi, TU Wenjun, ZHANG Qi, JIANG Sha. The Influencing Factors and the Multiple-hit Pathogenesis of Chicken Fatty Liver Hemorrhagic Syndrome [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2453-2469.
[5]	LIU Tongjun, ZHAO Pan, ZHAO Minmeng, LIU Long, CUI Hengmi, GONG Daoqing, GENG Tuoyu. Endoplasmic Reticulum Stress Marker Gene Grp78 Is Involved in Regulation of Immune/Inflammatory State of Goose Fatty Liver [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(4): 727-737.
[6]	LIU Ying, WANG Huanhuan, YAN Shuping, ZHU Bin, ZHANG Yuanshu. Study on the Interaction of Two Pathways of Renin Angiotensin System in Rat Nonalcoholic Simple Fatty Liver [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2309-2317.
[7]	YAO Xiao-lei, HUANG Xin-ai, XIAO Shen-hua, ZHENG Lin-feng, FAN Li-jie, JIN Yu-yue, LIU Zi-fei, ZHANG Yan-li, WANG Jie, WANG Feng. Expression Patterns and Correlation of Adiponectin Receptors and Testosterone Secretion Related-genes Expression in Male Reproductive Organs at Different Developmental Stages of Hu Sheep [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(8): 1642-1650.
[8]	TANG Ni, WANG Shu-yao, QI Jin-wen, WU Yuan-bing, LI Zhi-qiong. Research Progress on Adiponectin Regulating Lipid Metabolism [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2550-2557.
[9]	SHEN Liu-hong，JIANG Tao，WU Xiao-feng，JIANG Si-xun，XIAO Jin-bang，CAO Sui-zhong，YU Shu-min，DENG Jun-liang，ZUO Zhi-cai，PENG Guang-neng，MA Xiao-ping，ZHONG Zhi-jun，REN Zhi-hua，WANG Ya，HU Yan-chun. The Correlation between Adiponectin，Leptin，Visfatin in Placenta and Calf Birth Weight [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 185-192.
[10]	WANG Qian-qian，YANG Biao，XIA Li-li，SUN Xiao-xian，GENG Tuo-yu，GONG Dao-qing. Cloning of Goose Acetyl-Coenzyme A Acyltransferase 2 and Its Expression Pattern in the Development of Fatty Liver [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(4): 700-708.
[11]	SUN Yu-hang， XIA Cheng， SHU Shi， SUN Ling-wei， XU Chuang. Screening Protein Markers in Urine of Dairy Cows with Fatty Liver Disease Based on ITRAQ-HPLC-MS Technology [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(5): 844-852.
[12]	LIU Aisha;LI Yan;HU Wenfeng;WU Tongshan;LI Jiaqi;CHEN Zhenwei;JIANG Guanyao;LI Li . Expression of Porcine Globular Adiponectin Gene in Lactococcus lactis [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2012, 43(3): 353-357.
[13]	SHAO Kang;ZHOU Jie;WU Xiaoxue;SHU Baoping;LUO Lianhui;SHENG Sheng;ZHANG Jia;LI Weixin;YIN Zongjun. Developmental Patterns and Correlation of Adiponectin Receptors，LHR，CYP11A1 and StAR mRNA Expression in Testis of Wannan Hua Pigs [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2011, 42(12): 1680-1685.
[14]	XUE Mao-yun;DONG Biao;ZHANG Ying;YU Jian-feng;MENG He;GONG Dao-qing;. Identification and Prokaryotic Expression of Duck Adiponectin Gene [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2010, 41(10): 1232-1239.
[15]	ZHAO Ayong;;CHEN Guohong ;LU Lizhi ;ZHOU Qi . Isolation, Sequence Analysis and Expression Profile of IDH1 in Goose Liver [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2009, 40(7): 992-998.