间充质干细胞源外泌体对动物急性肾损伤的治疗作用及机制研究进展

doi:10.11843/j.issn.0366-6964.2025.01.011

Abstract

Abstract:

Acute kidney injury (AKI) is a kidney disease with rapid onset, complex etiology and high mortality, which poses a serious threat to the life and health of animals. In recent years, mesenchymal stem cells (MSCs) have been widely recognized as an effective method for the treatment of acute injury. However, due to the limitations of cell therapy, mesenchymal stem cell-derived exosomes (MSC-exos), a new cell-free treatment method that has attracted much attention, has attracted great attention in the treatment of acute kidney injury. MSC-exos can cure acute kidney injury through a variety of mechanisms such as inhibiting inflammation, reducing apoptosis, and regulating autophagy. This review summarizes the progress of MSC-exos in the treatment of AKI in animals, and aims to provide a theoretical reference for the clinical management and application of stem cell-derived exosomes in animals.

Key words: acute kidney injury, mesenchymal stem cells, exosomes

CLC Number:

S856.59

HE Haiyang, MA Baohua, PENG Sha. Research Progress on the Role and Mechanism of Mesenchymal Stem Cell-derived Exosomes in Animal Acute Renal Injury[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(1): 115-125.

Figures/Tables 2

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Research Progress on the Role and Mechanism of Mesenchymal Stem Cell-derived Exosomes in Animal Acute Renal Injury

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