牛结节性皮肤病免疫抗体监测的Meta分析

doi:10.11843/j.issn.0366-6964.2024.08.036

Abstract

Abstract:

Vaccination is an essential measure in preventing lumpy skin disease (LSD). However, the induction of humoral immune responses post-vaccination varies, and there is currently a lack of effective methods to evaluate vaccine immunogenicity. This study employed Meta-analysis using R software to statistically analyze published data on immune antibody monitoring for LSD, including subgroup analyses, to comprehensively assess the significance of immune antibody monitoring. A computer search was conducted in both Chinese and English databases, including CNKI, Wanfang Data, VIP, PubMed, and Web of Science. The search was up to July 2023, collecting relevant studies on immune antibody monitoring for LSD. Based on predetermined inclusion and exclusion criteria, a total of 24 articles were included. Among these, 13 articles were related to sheep/goat pox vaccine, and 13 articles were related to LSD vaccine. Two articles covered both sheep/goat pox and lumpy skin disease vaccines, with a total of 8, 638 samples, including 2, 782 positive samples. The outcome measure was the positive rate of immune antibodies. Meta-analysis results indicated an immune antibody level of 41% (95%CI: 27%~55%) for sheep/goat pox vaccine and 73% (95%CI: 64%~86%) for LSD vaccine. The homogeneity among studies was low, and there was no significant difference between the two vaccines (P=0.59). The literature related to sheep/goat pox vaccination(P=0.12) and LSD vaccination(P=0.077) both suggested no apparent publication bias. Subgroup analysis was based on immunization sites and detection methods, the mesults showed that there were no significant differences between different immunization sites(P=0.84) or detection methods(P=0.40), indicated non-heterogeneity in both subgroups. These findings suggest that there is significant uncertainty in evaluating immune protection effectiveness using immune antibody monitoring methods, comprehensive analysis and judgment will be necessitating in practical applications.

Key words: lumpy skin disease, sheep/goat pox, vaccine, immunization, antibody monitoring, Meta-analysis

CLC Number:

S858.23

Peng SHEN, Yi WANG, Weijie REN, Yongchun YANG, Houhui SONG, Zhiliang WANG. Meta Analysis of Immune Antibody Monitoring for Lumpy Skin Disease[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(8): 3649-3658.

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References 31

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作者(年份) Author(year)	疫苗类型¹⁾ Type of vaccine	检测方法 Detection method	ELISA包被抗原 ELISA coated antigen	样本量 Sample size	阳性数 Number of positives	免疫地点²⁾ Immunization site	评分 Score
张爱琼等^[5](2022)	1	ELISA	羊痘病毒	90	67	1	3
王图雅等^[6](2021)	1	ELISA	LSDV	260	140	1	2
赵晓军等^[7](2022)	1	ELISA	LSDV	120	80	1	3
王宇等^[8](2023)	1	VNT	—	20	8	2	3
闭璟珊等^[9](2021)	1	VNT	—	36	19	1	3
任娟等^[10](2022)	1	ELISA	羊痘病毒	5 520	567	1	1
朱真等^[11](2023)	1、2	ELISA	LSDV	95	77	2	3
Okur-Gumusova等^[12](2020)	1	ELISA	羊痘病毒	131	10	1	2
Haegeman等^[13](2021)	2	IPMA	LSDV	35	30	2	3
Safini等^[14](2022)	2	VNT	—	44	40	2	3
Hamdi等^[15](2020)	2	VNT, ELISA	羊痘病毒	126	23	2	3
Wolff等^[16](2020)	2	ELISA	羊痘病毒	12	11	2	3
Es-Sadeqy等^[17](2021)	2	VNT	—	30	29	2	3
Haegeman等^[18](2023)	2	VNT	—	30	14	2	3
Krešić等^[19](2020)	2	ELISA	羊痘病毒	291	250	1	2
Kumar等^[20](2023)	2	VNT	—	658	561	1, 2	2
Gari等^[21](2015)	2	IFAT	—	30	7	2	3
Hamdi等^[22](2020)	1、2	VNT	—	21	7	2	3
Milovanović等^[23](2019)	2	VNT	—	156	87	1	3
Sareyyupoĝlu等^[24](2023)	1	ELISA	LSDV	10	8	2	3
Bamouh等^[25](2021)	2	VNT	—	69	50	2	3
Abutarbush和Tuppurainen^[26](2018)	1	VNT	—	51	8	2	3
Hakobyan等^[27](2023)	1	ELISA	羊痘病毒	798	687	1	2
Burkov等^[28](2020)	1	ELISA	羊痘病毒	5	2	2	3

免疫环境 Immunization site	羊痘疫苗Sheep/goat pox vaccine			LSD疫苗LSD vaccine
免疫环境 Immunization site	样本量 Sample size	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)	样本量 Sample size	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)
自然环境 Natural environment	6 955	99.8%	43%(23%~63%)	1 186	95.5%	75%(58%~87%)
实验室环境 Laboratory environment	137	97.8%	39%(18%~59%)	360	84.1%	74%(59%~86%)

检测方法 Detection method	羊痘疫苗Sheep/Goat pox vaccine			LSD疫苗LSD vaccine
检测方法 Detection method	样本量 Sample size (n)	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)	样本量 Sample size (n)	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)
VNT	113	75.3%	26%(11%~40%)	1 037	93.7%	72%(58%~85%)
ELISA	6 938	99.7%	51%(24%~77%)	557	97.2%	69%(57%~82%)

包被抗原 ELISA coated antigen	羊痘疫苗Sheep/Goat pox vaccine			LSD疫苗LSD vaccine
包被抗原 ELISA coated antigen	样本量 Sample size (n)	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)	样本量 Sample size (n)	异质性 Heterogeneity (I²)	免疫抗体水平 Immune antibody levels (95%CI)
羊痘病毒	6 544	99.9%	34%(7%~60%)	394	33.1%	85%(82%~89%)
LSDV	435	98.1%	73%(55%~92%)	—	—	—

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Meta Analysis of Immune Antibody Monitoring for Lumpy Skin Disease

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