我国猪链球菌对常用抗菌药物耐药性的Meta分析

doi:10.11843/j.issn.0366-6964.2024.07.034

Abstract

Abstract:

To systematically analyze the antimicrobial resistance of Streptococcus suis (S. suis) to commonly used antimicrobials in China over the past decade, and analyze their temporal changes and geographic characteristics, so as to provide scientific guidance for monitoring the resistance trends of S. suis, rational use of antimicrobials, and development of new drugs. In this project, the existing literature was collected and organized, and Meta-analysis was performed. Inclusion and exclusion criteria were set up, relevant literature was screened, and a database on the resistance status of S. suis to commonly used antimicrobial drugs in China was established, and the literature in the database was subjected to the steps of quality evaluation, heterogeneity test, publication bias test, and subgroup analysis as well as statistical calculations. The results showed that different resistance status of S. suis to 20 commonly used antimicrobial drugs, with the highest resistant rates to tetracyclines and lincosamides (> 80%, 91% for tetracycline, 84% for lincomycin, 81% for doxycycline and 81% for clindamycin), followed by aminoglycosides (50% to 80%, 76% for erythromycin, 76% for kanamycin 75%, azithromycin 74%, streptomycin 70%, cotrimoxazole 65%, gentamicin 64%, amikacin 55%); penicillins, cephalosporins, phenicols, fluoroquinolones (10% to 40%; enrofloxacin 37%, florfenicol 31%, ciprofloxacin 30%, penicillin 24%, chloramphenicol 24%, ampicillin 13%, ceftiofur 12%), and vancomycin, with the lowest resistant rate of 4%. Subgroup analysis showed that the resistant rate varied depending on their isolation year and area. Increasing resistance of S. suis to commonly used antimicrobials were observed during the past decade. Strategies are urgently needed to tackle antimicrobial resistance of S. suis in China in premise of strengthen surveillance, reduce the irrational use and explore the resistance mechanism.

Key words: Streptococcus suis, antimicrobials, resistance rate, Meta-analysis

CLC Number:

S859.7

Sijin TIAN, Jiaqi ZHAO, Xiaoming WANG, Liping WANG, Jinhu HUANG. Antimicrobial Resistance of Streptococcus suis in China: a Systematic Review and Meta-analysis[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(7): 3163-3176.

Figures/Tables 6

Table 1

Fig. 1

Table 2

General information and quality scores of the included papers"

序号 No.	文章简称 Paper	采样时间 Time	采样地区 Area	健康状况 Condition	检测方法 Method	质控菌株 Strain	标准 Standard	菌株数 No. of strains	评分 Score
1	龚团莲2016^[5]	未提及	未提及	未提及	K-B纸片法	猪链球菌ATCC700794	CLSI	26	6
2	黄金虎2013^[6]	2005—2010年	江苏、江西、四川、河北	健康、患病	微量稀释法	金黄色葡萄球菌ATCC29213	CLSI	46	8
3	王长珍2019^[7]	2017年	河南、广东、宁夏、黑龙江	健康	微量稀释法	大肠杆菌ATCC 25922、金黄色葡萄球菌ATCC 29213	CLSI	46	9
4	刘修权2014^[8]	未提及	北京	疑似患病	K-B纸片法	未提及	NCCLS	56	7
5	贡嘎2016^[9]	未提及	西藏	未提及	K-B纸片法	未提及	公司	6	5
6	彭少静2016^[10]	2014年	重庆	未提及	K-B纸片法	金黄色葡萄球菌ATCC29213	公司	18	9
7	都玉2022^[11]	2021年	重庆	健康	微量稀释法	金黄色葡萄球菌ATCC29213	CLSI	87	9
8	黄文明2013^[12]	2010—2012年	广东	未提及	微量稀释法	金黄色葡萄球菌ATCC29213	CLSI	56	6
9	韩宁2022^[13]	未提及	广东	未提及	微量稀释法	金黄色葡萄球菌ATCC29213	CLSI、EUCAST	40	8
10	王治方2021^[14]	2018—2020年	河南	患病	K-B纸片法	未提及	CLSI	10	7
11	苏红辽2022^[15]	未提及	河南	未提及	K-B纸片法	未提及	未提及	21	8
12	李文娴2018^[16]	2009—2011年	河南	患病	K-B纸片法	未提及	未提及	8	6
13	徐引弟2018^[17]	2016—2017年	河南	患病	K-B纸片法	未提及	公司	87	7
14	刘泽文2021^[18]	未提及	湖北	患病	K-B纸片法	未提及	公司	16	8
15	龙剑2019^[19]	2018年	湖南	患病	K-B纸片法	未提及	未提及	10	7
16	王大春2021^[20]	2019—2020年	湖南	健康	K-B纸片法	未提及	CLSI	22	8
17	黄建华2014^[21]	未提及	湖南	疑似患病	K-B纸片法	未提及	未提及	11	7
18	杜凡姝2018^[22]	2016年	江苏	健康、患病	微量稀释法	未提及	CLSI	107	6
19	谭美芳2020^[23]	2017—2019年	江西	健康	K-B纸片法	金黄色葡萄球菌ATCC6538	CLSI	112	8
20	韩瑞2021^[24]	2018—2021年	江西	患病	K-B纸片法	未提及	CLSI	10	8
21	洪家兵2018^[25]	2014—2016年	江西	疑似患病	K-B纸片法	未提及	CLSI	62	7
22	陈强2013^[26]	2012年	辽宁	疑似患病	K-B纸片法	未提及	未提及	9	5
23	孙佳楠2017^[27]	2015年	辽宁	健康、患病	微量稀释法	链球菌ATCC29212	CLSI	92	8
24	岳修伟2013^[28]	2010—2011年	上海	患病	K-B纸片法	未提及	未提及	31	7
25	王晓旭2018^[29]	2004—2017年	上海	未提及	微量稀释法	肺炎链球菌ATCC49619	CLSI	150	8
26	池晶晶2019^[30]	未提及	天津	患病	K-B纸片法	未提及	CLSI	7	6
27	吴三南2021^[31]	未提及	湖北	患病	K-B纸片法	未提及	未提及	18	7
28	祝令伟2017^[32]	未提及	吉林	未提及	K-B纸片法	未提及	CLSI	52	7
29	吕转平2015^[33]	未提及	新疆	患病	K-B纸片法	未提及	未提及	20	7
30	侍丽君2016^[34]	未提及	新疆	患病	K-B纸片法	未提及	国家抗菌药物细菌耐药性检测中心	8	6
31	刘召颖2022^[35]	2020—2021年	浙江	健康	微量稀释法	金黄色葡萄球菌ATCC29213	CLSI	68	9
32	李儒曙2014^[36]	未提及	广东	患病	K-B纸片法	未提及	未提及	20	5
33	关琳2019^[37]	2005—2017年	广东、山东、江苏、上海	健康、患病	K-B纸片法	金黄色葡萄球菌ATCC29213	CLSI	15	8
34	何芳2015^[38]	2014年	湖南	疑似患病	K-B纸片法	未提及	未提及	6	6
35	付学才2014^[39]	未提及	湖南	患病	K-B纸片法	未提及	未提及	6	6
36	蔡田2019^[40]	未提及	河南、江西、湖南、山西、安徽、陕西、湖北	疑似患病	微量稀释法	猪链球菌ATCC43765	未提及	165	8
37	刘宝玲2022^[41]	2016—2020年	广东	未提及	K-B纸片法	未提及	未提及	34	8
38	王治方2020^[42]	2019年	河南	疑似患病	K-B纸片法	未提及	NCCLS	68	8
39	易新健2017^[43]	2016年	全国	患病	K-B纸片法	未提及	CLSI	53	7
40	张维谊2016^[44]	2013—2015年	上海	患病	微量稀释法	猪链球菌ATCC43300	CLSI	59	8
41	Tan M F 2020^[45]	2017—2019年	江西	健康	K-B纸片法	肺炎链球菌ATCC49619	CLSI	107	7
42	Zhang C P 2015^[46]	2005—2012年	江苏、四川、广东、广西、安徽、河南、河北、江西、山东、北京	健康、患病	微量稀释法	肺炎链球菌ATCC49619	CLSI	96	7
43	Peng L 2019^[47]	2013—2016年	华南	健康、患病	K-B纸片法	肺炎链球菌ATCC49619	NCCLS	81	8
44	Chen L 2013^[48]	2008—2010年	中国14个省份	患病	微量稀释法	肺炎链球菌ATCC49619	CLSI	106	8
45	Zhang C Y 2020^[49]	2016—2018年	河南、北京、四川、河北、重庆、山东	健康	微量稀释法	大肠杆菌ATCC 25922、金黄色葡萄球菌ATCC 29213	CLSI	223	8
46	Yu Y 2018^[50]	2008—2013年	广东	患病	微量稀释法	猪链球菌ATCC43765	CLSI	11	8
47	Guo Y 2022^[51]	2018—2019年	辽宁	健康	微量稀释法	肺炎链球菌ATCC49619	CLSI	22	8

Table 2

Table 3

Meta-analysis results of the resistance rate of S. suis to 20 antimicrobials"

药物 Drug	文献数 No. of papers	菌株总数 No. of strains	耐药菌株数 No. of resistant strains	合并耐药率/% (95%CI) Resistance rate	异质性 Heterogeneity		使用模型 Model	Z值	P值	敏感性分析 Sensitiveness		Egger’s 检验 Egger’s test
药物 Drug	文献数 No. of papers	菌株总数 No. of strains	耐药菌株数 No. of resistant strains	合并耐药率/% (95%CI) Resistance rate	P值	I²值/%	使用模型 Model	Z值	P值	最小值 Min	最大值 Max	Egger’s 检验 Egger’s test
四环素 Tetracycline	38	2 106	1 890	91(86, 95)	0.00	89.64	R	32.16	0.00	0.83	0.96	0.188
林可霉素 Lincomycin	17	544	461	84(69, 95)	0.00	92.45	R	12.13	0.00	0.62	0.98	0.196
多西环素 Doxycycline	18	635	523	81(69, 91)	0.00	89.75	R	14.99	0.00	0.67	0.92	0.092
克林霉素 Clindamycin	20	1 336	1 111	81(69, 90)	0.00	95.34	R	15.35	0.00	0.67	0.92	0.080
红霉素 Erythromycin	32	2 076	1 588	76(67, 83)	0.00	94.22	R	20.18	0.00	0.65	0.83	0.136
卡那霉素 Kanamycin	15	541	366	75(61, 87)	0.00	90.65	R	12.54	0.00	0.54	0.85	0.466
阿奇霉素 Azithromycin	16	729	542	74(61, 86)	0.00	92.38	R	13.61	0.00	0.58	0.86	0.357
链霉素 Streptomycin	23	868	481	70(55, 83)	0.00	94.15	R	11.81	0.00	0.48	0.78	0.032
复方新诺明 Compound sulfamethoxazole	15	546	308	65(51, 79)	0.00	89.51	R	11.42	0.00	0.42	0.76	0.266
庆大霉素 Gentamicin	23	996	620	64(51, 77)	0.00	93.42	R	12.47	0.00	0.46	0.73	0.569
阿米卡星 Amikacin	19	565	348	55(38, 72)	0.00	93.25	R	8.54	0.00	0.39	0.73	0.127
恩诺沙星 Enrofloxacin	23	1 058	333	37(26, 50)	0.00	92.28	R	9.20	0.00	0.24	0.49	0.088
氟苯尼考 Florfenicol	27	1 154	359	31(22, 41)	0.00	89.95	R	9.61	0.00	0.23	0.45	0.384
环丙沙星 Ciprofloxacin	28	1 230	404	30(22, 38)	0.00	87.06	R	11.33	0.00	0.24	0.42	0.969
青霉素 Penicillin	37	1 996	468	24(15, 34)	0.00	95.36	R	7.68	0.00	0.17	0.38	0.140
氯霉素 Chloramphenicol	18	1 027	235	24(12, 38)	0.00	95.43	R	5.71	0.00	0.12	0.43	0.215
氨苄西林 Ampicillin	29	1 138	205	13(5, 23)	0.00	93.71	R	4.56	0.00	0.09	0.31	0.571
头孢噻呋 Ceftiofur	11	812	110	12(3, 26)	0.00	95.46	R	3.26	0.00	0.01	0.34	0.374
阿莫西林 Amoxicillin	23	826	115	10(4, 19)	0.00	90.63	R	4.11	0.00	0.04	0.25	0.464
万古霉素 Vancomycin	13	939	38	4(0, 9)	0.00	88.97	R	2.64	0.00	-0.04	0.11	0.007

Table 3

Fig. 2

Fig. 3

References 52

1	HAAS B , GRENIER D . Understanding the virulence of Streptococcus suis: a veterinary, medical, and economic challenge[J]. Méd Mal Infect, 2018, 48 (3): 159- 166. doi: 10.1016/j.medmal.2017.10.001
2	LUN Z R , WANG Q P , CHEN X G , et al. Streptococcus suis: an emerging zoonotic pathogen[J]. Lancet Infect Dis, 2007, 7 (3): 201- 209. doi: 10.1016/S1473-3099(07)70001-4
3	肖延光, 夏新萌, 王宝菊, 等. 不同年龄、地区、饲养模式下猪链球菌耐药性比较[J]. 养殖与饲料, 2022, 21 (1): 84- 86.
	XIAO Y G , XIA X M , WANG B J , et al. Comparison of drug resistance of Streptococcus suis in different ages, regions and feeding patterns[J]. Animals Breeding and Feed, 2022, 21 (1): 84- 86.
4	PORMOHAMMAD A , NASIRI M J , AZIMI T . Prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis[J]. Infect Drug Resist, 2019, 12, 1181- 1197. doi: 10.2147/IDR.S201324
5	龚团莲. 26株猪链球菌对抗菌药物的敏感性分析[J]. 畜牧与饲料科学, 2016, 37 (1): 16-17, 21.
	GONG T L . Antimicrobial resistance of 26 strains of Streptococcus suis isolated from veterinary clinical specimens[J]. Animal Husbandry and Feed Science, 2016, 37 (1): 16-17, 21.
6	黄金虎, 刘民星, 商可心, 等. 46株猪链球菌对大环内酯类抗生素的耐药性及PFGE分型[J]. 南京农业大学学报, 2013, 36 (4): 105- 110.
	HANG J H , LIU M X , SHANG K X , et al. Macrolide resistance and pulsed-field gel electrophoresis typing of 46 Streptococcus suis isolates[J]. Journal of Nanjing Agricultural University, 2013, 36 (4): 105- 110.
7	王长珍, 刘文宇, 祝瑶, 等. 2017年我国4个省份屠宰场猪链球菌的分离鉴定及耐药性分析[J]. 中国预防兽医学报, 2019, 41 (12): 1210- 1214.
	WANG C Z , LIU W Y , ZHU Y , et al. Identification and antimicrobial resistance of Streptococcus suis in slaughterhouses from four different provinces of China[J]. Chinese Journal of Preventive Veterinary Medicine, 2019, 41 (12): 1210- 1214.
8	刘修权, 贾泽颖, 孙玉芳, 等. 北京地区四个规模化猪场的猪链球菌病流行病学调查[J]. 中国猪业, 2014, 9 (7): 33- 36.
	LIU X Q , JIA Z Y , SUN Y F , et al. Epidemiological survey of Streptococcus suis disease in four large-scale pig farms in Beijing area[J]. China Swine Industry, 2014, 9 (7): 33- 36.
9	贡嘎, 益西措姆, 罗润波, 等. 藏猪链球菌的分离鉴定及耐药性研究[J]. 中国人兽共患病学报, 2016, 32 (11): 987- 990.
	GONG G , YI X C M , LUO R B , et al. Isolation and identification of strain SS and antibiotic resistance in Tibet pig[J]. Chinese Journal of Zoonoses, 2016, 32 (11): 987- 990.
10	彭少静, 邓华英, 张媛媛, 等. 重庆地区猪肉样品中猪链球菌污染、血清型、耐药性及致病性[J]. 食品科学, 2016, 37 (4): 233- 237.
	PENG S J , DENG H Y , ZHANG Y Y , et al. Contamination, serotype, drug resistance and pathogenicity of Streptococcus suis from pork samples in Chongqing[J]. Food Science, 2016, 37 (4): 233- 237.
11	都玉, 刘召颖, 彭泽仁, 等. 重庆屠宰场猪链球菌感染的调查[J]. 畜牧与兽医, 2022, 54 (6): 58- 65.
	DU Y , LIU Z Y , PENG Z R , et al. Investigation on Streptococcus suis infection in some slaughterhouses of Chongqing[J]. Animal Husbandry & Veterinary Medicine, 2022, 54 (6): 58- 65.
12	黄文明, 欧阳昀, 张民泽, 等. 广东地区猪链球菌的耐药性特点及四环素耐药基因携带情况[J]. 中国畜牧兽医, 2013, 40 (5): 54- 58.
	HUANG W M , OU Y J , ZHANG M Z , et al. Resistance characteristics and distribution of tetracycline resistance genes in Streptococcus suis from pigs in Guangdong[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40 (5): 54- 58.
13	韩宁, 李杰, 陈佳文, 等. 广东省某猪场链球菌的分离鉴定及耐药性分析[J]. 中国兽医学报, 2022, 42 (7): 1405- 1410.
	HAN N , LI J , CHEN J W , et al. Identification and resistance of Streptococcus from a pig farm in Guangdong Province[J]. Chinese Journal of Veterinary Science, 2022, 42 (7): 1405- 1410.
14	王治方, 徐引弟, 焦文强, 等. 规模化猪场常见呼吸道细菌性病原的调查[J]. 中国动物传染病学报, 2023, 31 (2): 181- 185.
	WANG Z F , XU Y D , JIAO W Q , et al. Investigation of common bacterial pathogens in porcine respiratory tracts on large scale farms[J]. Chinese Journal of Veterinary Parasitology, 2023, 31 (2): 181- 185.
15	苏红辽, 耿向华, 韩红霞, 等. 河南省安阳市猪链球菌2型分布及其药物敏感性[J]. 中国动物检疫, 2022, 39 (9): 26- 30.
	SU H L , GENG X H , HAN H X , et al. Distribution and drug sensitivity of Streptococcus suis type 2 in Anyang City of Henan Province[J]. China Animal Health Inspection, 2022, 39 (9): 26- 30.
16	李文娴, 王丽荣, 王三虎. 河南省部分猪场猪链球菌的分离鉴定及耐药性分析[J]. 浙江农业科学, 2018, 59 (12): 2329- 2331.
	LI W X , WANG L R , WANG S H . Isolation, identification and drug susceptibility of Streptococcus suis from some pig farms in Henan Province[J]. Journal of Zhejiang Agricultural Sciences, 2018, 59 (12): 2329- 2331.
17	徐引弟, 孙帅杰, 王治方, 等. 河南省猪链球菌的分离鉴定及耐药性分析[J]. 中国畜牧兽医, 2018, 45 (2): 501- 509.
	XU Y D , SUN S J , WANG Z F , et al. Isolation, identification and drug resistance analysis of Streptococcus suis in Henan Province[J]. China Animal Husbandry & Veterinary Medicine, 2018, 45 (2): 501- 509.
18	刘泽文, 袁芳艳, 刘威, 等. 湖北省猪2型链球菌的分布及耐药性分析[J]. 动物医学进展, 2021, 42 (1): 125- 129.
	LIU Z W , YUAN F Y , LIU W , et al. Distribution and drug resistance of Streptococcus suis type 2 in Hubei Province[J]. Progress in Veterinary Medicine, 2021, 42 (1): 125- 129.
19	龙剑, 张古月, 余俊达, 等. 湖南省部分规模猪场保育仔猪细菌感染调查及药敏检测分析[J]. 养猪, 2019, (4): 93- 96.
	LONG J , ZHANG G Y , YU J D , et al. Identification and antibiotic susceptibility of bacterial isolates from nursery pigs in some largescale swine farms in Hunan Province[J]. Swine Production, 2019, (4): 93- 96.
20	王大春, 李庆丰. 湖南湘潭县屠宰生猪沙门氏菌和链球菌感染情况调查及耐药性分析[J]. 养猪, 2021, (3): 121- 123.
	WANG D C , LI Q F . Investigation of Salmonella and Streptococcus infections in slaughtered live pigs in Xiangtan County, Hunan Province and analysis of drug resistance[J]. Swine Production, 2021, (3): 121- 123.
21	黄建华, 刘将军. 湖南永州市猪链球菌病病原分群鉴定和药敏试验[J]. 黑龙江畜牧兽医, 2014, (16): 96- 97.
	HUANG J H , LIU J J . Identification of Streptococcus suis subgroups and drug sensitivity test in Yongzhou City, Hunan Province, China[J]. Heilongjiang Animal Science and Veterinary Medicine, 2014, (16): 96- 97.
22	杜凡姝, 吕茜, 段锻, 等. 江苏苏北地区猪链球菌耐药性调查及万古霉素耐药基因检测[J]. 畜牧与兽医, 2018, 50 (12): 32- 36.
	DU F S , LYU X , DUAN D , et al. Antimicrobial susceptibility and emergence of vancomycin resistance genes in Streptococcus suis[J]. Animal Husbandry & Veterinary Medicine, 2018, 50 (12): 32- 36.
23	谭美芳, 谭佳, 曾艳兵, 等. 江西省5个规模化猪场健康猪群中猪链球菌的流行病学调查及耐药性研究[J]. 江西农业大学学报, 2020, 42 (4): 728- 735.
	TAN M F , TAN J , ZENG Y B , et al. Epidemiological investigation and drug resistance analysis of Streptococcus suis in clinically healthy pigs from five large-scale pig farms in Jiangxi Province[J]. Acta Agriculturae Universitatis Jiangxiensis, 2020, 42 (4): 728- 735.
24	韩瑞, 杨行, 张文波, 等. 江西省猪链球菌的分离鉴定及耐药基因、毒力基因检测分析[J]. 中国动物传染病学报, 2021, 1- 17.
	HAN R , YANG X , ZHANG W B , et al. Isolation and identification of Streptococcus suis and detection and analysis of drug resistance gene and virulence gene[J]. Chinese Journal of Animal Infectious Diseases, 2021, 1- 17.
25	洪家兵, 陶政, 黄奕雯, 等. 江西省猪链球菌临床分离株毒力基因检测及药物敏感性分析[J]. 中国兽医杂志, 2018, 54 (9): 27- 31.
	HONG J B , TAO Z , HUANG Y W , et al. Determination of the virulence genes and drug sensitivity analysis of Streptococcus suis clinical isolated strains in Jiangxi Province[J]. Chinese Journal of Veterinary Medicine, 2018, 54 (9): 27- 31.
26	陈强, 齐丽娜, 甄志刚, 等. 辽宁省猪源链球菌的分离鉴定及药敏试验[J]. 畜牧与兽医, 2013, 45 (7): 83- 85.
	CHEN Q , QI L N , ZHEN Z G , et al. Isolation and identification of Streptococcus suis of swine origin in Liaoning Province and drug sensitivity[J]. Animal Husbandry & Veterinary Medicine, 2013, 45 (7): 83- 85.
27	孙佳楠, 李欣南, 伊会杰, 等. 辽西地区猪源与人源链球菌耐药性及相关耐药基因同源性分析[J]. 畜牧与兽医, 2017, 49 (1): 55- 60.
	SUN J N , LI X N , YI H J , et al. Resistance and homology analysis of the resistance-related genes in Streptococcus isolated from pig and human in western area of Liaoning Province[J]. Animal Husbandry & Veterinary Medicine, 2017, 49 (1): 55- 60.
28	岳修伟, 蔡雪辉, 王淑杰, 等. 上海部分地区猪链球菌2型的流行病学调查及其耐药性[J]. 上海交通大学学报: 农业科学版, 2013, 31 (1): 72- 76.
	YUE X W , CAI X H , WANG S J , et al. Epidemiology and drug resistance of Streptococcus suis serotype 2 isolated from Shanghai[J]. Journal of Shanghai Jiaotong University: Agricultural Science, 2013, 31 (1): 72- 76.
29	王晓旭, 宁昆, 徐锋, 等. 上海市150株猪链球菌对8种常见抗菌药物的耐药情况[J]. 中国动物检疫, 2018, 35 (9): 27-31, 35.
	WANG X X , NING K , XU F , et al. Study on drug resistance of Streptococcus suis to 8 kinds of common antibiotics in Shanghai City[J]. China Animal Health Inspection, 2018, 35 (9): 27-31, 35.
30	池晶晶, 董志民, 田向学, 等. 天津地区猪链球菌3型菌株的致病性及耐药特性研究[J]. 中国畜牧兽医, 2019, 46 (12): 3740- 3748.
	CHI J J , DONG Z M , TIAN X X , et al. Study on pathogenicity and drug resistance of Streptococcus suis type 3 strain in Tianjin[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46 (12): 3740- 3748.
31	吴三南. 通山县某猪场猪链球菌分离株毒力特征及耐药性研究[J]. 湖北畜牧兽医, 2021, 42 (4): 12- 13.
	WU S N . Study on virulence characteristics and drug resistance of Streptococcus suis isolates from a pig farm in Tongshan County, China[J]. Hubei Journal of Animal and Veterinary Sciences, 2021, 42 (4): 12- 13.
32	祝令伟, 纪雪, 李丽红, 等. 屠宰场猪链球菌分离菌株分型及其致病性和耐药性分析[J]. 中国兽医学报, 2017, 37 (2): 272- 277.
	ZHU L W , JI X , LI L H , et al. Molecular characterization, pathogenicity and drug-resistance of Streptococcus suis isolated from slaughterhouse pigs[J]. Chinese Journal of Veterinary Science, 2017, 37 (2): 272- 277.
33	吕转平, 剡根强. 新疆库尔勒猪源链球菌分离培养及药敏试验[J]. 山东畜牧兽医, 2015, 36 (9): 12- 13.
	LV Z P , SHAN G Q . Isolation, cultivation, and antimicrobial susceptibility testing of Streptococcus suis from swine in Kuerle, Xinjiang[J]. Shandong Journal of Animal Science and Veterinary Medicine, 2015, 36 (9): 12- 13.
34	侍丽君. 昭苏县猪链球菌病病原的分离与鉴定[J]. 新疆畜牧业, 2016, (1): 30- 33.
	SHI L J . Isolation and characterization of the pathogen of Streptococcus suis in Zhaosu[J]. Xin Jiang Xu Mu Ye, 2016, (1): 30- 33.
35	刘召颖, 朱夏雨, 牛洪颖, 等. 浙江某市屠宰场猪链球菌血清型、耐药及致病特征[J]. 微生物学报, 2022, 62 (8): 3236- 3250.
	LIU Z Y , ZHU X Y , NIU H Y , et al. Serotypes, antimicrobial resistance, and pathogenic characteristics of Streptococcus suis isolated from a slaughterhouse in an area of Zhejiang Province[J]. Acta Microbiologica Sinica, 2022, 62 (8): 3236- 3250.
36	李儒曙, 邱民希. 猪链球菌2型、1型和7型对临床常见药物的敏感性试验[J]. 养猪, 2014, (2): 105- 107.
	LI R S , QIU M X . Sensitivity testing of Streptococcus suis serotypes 2, 1, and 7 to commonly used clinical drugs[J]. Swine Production, 2014, (2): 105- 107.
37	关琳, 王丹丹, 祝昊丹, 等. 猪链球菌9型分离株的耐药性及耐药基因分析[J]. 中国人兽共患病学报, 2019, 35 (11): 1015- 1020.
	GUAN L , WANG D D , ZHU H D , et al. Analysis of drug resistance and resistance gene of Streptococcus suis serotype 9 isolates[J]. Chinese Journal of Zoonoses, 2019, 35 (11): 1015- 1020.
38	何芳, 周望平, 邱美珍, 等. 猪链球菌的分离、16S rRNA鉴定及药敏试验[J]. 养猪, 2015, (3): 108- 109.
	HE F , ZHOU W P , QIU M Z , et al. Isolation, 16S rRNA identification, and antimicrobial susceptibility testing of Streptococcus suis[J]. Swine Production, 2015, (3): 108- 109.
39	傅学才. 猪链球菌的分离、16S rRNA鉴定及药敏实验[J]. 湖南畜牧兽医, 2014, (3): 21- 23.
	FU X C . Isolation, 16S rRNA identification, and antimicrobial susceptibility testing of Streptococcus suis[J]. Hunan Journal of Animal Science & Veterinary Medicine, 2014, (3): 21- 23.
40	蔡田, 罗行炜, 徐引第, 等. 猪链球菌对大环内酯类抗生素的耐药性研究[J]. 河南农业大学学报, 2019, 53 (1): 73- 81.
	CAI T , LUO X W , XU Y D , et al. Research on the resistance of Streptococcus suis to macrolide antibiotics[J]. Journal of Henan Agricultural University, 2019, 53 (1): 73- 81.
41	刘宝玲, 楚品品, 李春玲, 等. 猪链球菌临床分离株对四环素类抗生素的耐药性和耐药基因分析[J]. 中国畜牧兽医, 2022, 49 (7): 2796- 2804.
	LIU B L , CHU P P , LI C L , et al. Analysis of resistance and resistance genes of Streptococcus suis clinical isolates to tetracyclines[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49 (7): 2796- 2804.
42	王治方, 白红杰, 徐引弟, 等. 猪链球菌流行优势菌株的调查及耐药性[J]. 中国兽医学报, 2020, 40 (12): 2327- 2332.
	WANG Z F , BAI H J , XU Y D , et al. Prevalence and drug resistance of Streptococcus suis[J]. Chinese Journal of Veterinary Science, 2020, 40 (12): 2327- 2332.
43	易新健, 刘准, 凌云志, 等. 猪链球菌耐药现状分析及防控[J]. 养猪, 2017, (4): 107- 108.
	YI X J , LIU Z , LING Y Z , et al. Analysis and control of Streptococcus suis[J]. Swine Production, 2017, (4): 107- 108.
44	张维谊, 王晓旭, 宁昆, 等. 猪源猪链球菌耐药情况分析[J]. 中国农业信息, 2016, 28 (11): 101- 103.
	ZHANG W Y , WANG X X , NING K , et al. Analysis of drug resistance in Streptococcus suis from swine sources[J]. China Agricultural Informatics, 2016, 28 (11): 101- 103.
45	TAN M F , TAN J , ZENG Y B , et al. Antimicrobial resistance phenotypes and genotypes of Streptococcus suis isolated from clinically healthy pigs from 2017 to 2019 in Jiangxi Province, China[J]. J Appl Microbiol, 2021, 130 (3): 797- 806.
46	ZHANG C P , ZHANG Z Q , SONG L , et al. Antimicrobial resistance profile and genotypic characteristics of Streptococcus suis capsular type 2 isolated from clinical carrier sows and diseased pigs in China[J]. Biomed Res Int, 2015, 2015, 284303.
47	PENG L , XU C B , YANG X F , et al. Antimicrobial susceptibility, serotypes, and genetic diversity of Streptococcus suis in diseased and healthy pigs in Southern China[J]. Kafkas Univ Vet Fak Derg, 2019, 25 (4): 451- 458.
48	CHEN L , SONG Y J , WEI Z G , et al. Antimicrobial susceptibility, tetracycline and erythromycin resistance genes, and multilocus sequence typing of Streptococcus suis isolates from diseased pigs in China[J]. J Vet Med Sci, 2013, 75 (5): 583- 587.
49	ZHANG C Y , ZHANG P , WANG Y , et al. Capsular serotypes, antimicrobial susceptibility, and the presence of transferable oxazolidinone resistance genes in Streptococcus suis isolated from healthy pigs in China[J]. Vet Microbiol, 2020, 247, 108750.
50	YU Y , FANG J T , ZHENG M , et al. Combination therapy strategies against multiple-resistant Streptococcus suis[J]. Front Pharmacol, 2018, 9, 489.
51	GUO Y , LI R , SUN X , et al. In vitro antibiotic susceptibility, virulence genes profiles and integrons of Streptococcus suis isolates from pig herds in Liaoning Province of China[J]. Pak Vet J, 2021, 42, 117- 121.
52	赵琪, 李霆, 姜子楠, 等. 2019年我国兽用抗菌药物使用情况分析研究[J]. 中国兽药杂志, 2022, 56 (1): 71- 76.
	ZHAO Q , LI T , JIANG Z N , et al. Investigation on antimicrobial consumption in animals in China in 2019[J]. Chinese Journal of Veterinary Drug, 2022, 56 (1): 71- 76.

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Antimicrobial Resistance of Streptococcus suis in China: a Systematic Review and Meta-analysis

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