Acta Veterinaria et Zootechnica Sinica ›› 2024, Vol. 55 ›› Issue (5): 1893-1903.doi: 10.11843/j.issn.0366-6964.2024.05.008

• REVIEW • Previous Articles     Next Articles

Research Progress on LuxS/AI-2 Quorum Sensing of Rumen Microbe in Ruminants

LONG Tanghui, ZHOU Jianghui, ZHAN Yanbo, ZHANG Jian, ZHAO Xianghui, LI Yanjiao, OUYANG Kehui, QIU Qinghua*   

  1. Jiangxi Province Engineering Research Center of Feed Development/Jiangxi Province Key Laboratory of Animal Nutrition/College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China
  • Received:2023-07-07 Online:2024-05-23 Published:2024-05-27

Abstract: Quorum sensing (QS) is a communication mechanism utilized by bacteria to facilitate intra-species or inter-species communication through the signaling molecules. Through this communication mechanism, microorganisms can collectively conduct physiological functions or regulate behaviors that cannot be achieved by microbial individual. These functions include biofilm formation, toxin secretion, bioluminescence, and other adaptive responses to enhance the adaptability of microorganisms against external stress environment. Recently, multi-omics studies have revealed that LuxS/AI-2 QS, mediated by the autoinducer-2 (AI-2) signaling molecule and regulated by the LuxS protein, serves as the primary communication mechanism among rumen microbe, influencing their efficiency in feed utilization. This review provides a summary of the LuxS/AI-2 QS in rumen microbe, focusing on the chemical structure of AI-2 and its transduction pathways. The roles of LuxS/AI-2 QS in rumen microbial colonization and feed digestion in ruminants were reviewed, as well as the potential roles of LuxS/AI-2 QS in feed digestion and stress regulation. This review may provide a theoretical reference for production strategy by regulating the digestive metabolism and homeostasis of rumen microbe through LuxS/AI-2 QS.

Key words: LuxS/AI-2 quorum sensing, biofilm, rumen microbe, community stability, feed digestion

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