Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (9): 3605-3612.doi: 10.11843/j.issn.0366-6964.2023.09.002

• REVIEW • Previous Articles     Next Articles

Advances of IGF2BP2-Mediated m6A Modification on Animal Fat Deposition

HAN Haozhe, TIE Zihang, PANG Weijun, CAI Rui*   

  1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
  • Received:2023-03-15 Published:2023-09-22

Abstract: With the improvement of people's living standards, high-quality meat products of agricultural animal have been favored by consumers in China for the past few years. Fat deposition is an important factor affecting meat quality. Therefore, it is of great significance to clarify the molecular mechanism of high-quality meat formation. N6-methyladenylation modification (m6A) is the most abundant modifications in eukaryotic mRNA, which is related to the transport, expression, degradation process of RNA and is involved in regulating a variety of biological processes. Studies have shown that m6A modifications mediated by human insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) play a key role in animal fat deposition. This review will focus on m6A, IGF2BP2 and their role as well as molecular mechanism in animal fat deposition to provide candidate genes and scientific basis for the improvement of meat quality in the future.

Key words: m6A modification, IGF2BP2, fat deposition, animals

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