Kisspeptin/GPR54在哺乳动物繁殖上的研究进展

doi:10.11843/j.issn.0366-6964.2020.10.002

Abstract

Abstract: Kisspeptin is the coding product of the Kiss1 gene, which can bind to its G protein-coupled receptor GPR54 and activate the PLC/PKC/MAPK signaling pathway, thereby playing an important role in inhibiting tumor metastasis, regulating animal reproduction and initiating the estrus. Kisspeptin/GPR54 is not only expressed in hypothalamus but also widely expressed in pituitary and gonads, which is involved in regulating reproduction of animals. We summarizes the latest researches about kisspeptin/GPR54 regulating reproduction and puberty initiation of animals in the hypothalamic-pituitary-gonadal axis. More importantly, the location and distribution of kisspeptin/GPR54 and its possible direct regulation on gametogenesis were highlighted in the gonads in this article. Besides, some problems faced in kisspeptin/GPR54 related research and its future research directions were concluded, which will better help the research and application of kisspentin/GPR54 in animal reproduction.

Key words: kisspeptin, GPR54, reproduction, gonad, puberty

CLC Number:

S814.1

DU Xuxu, MEI Shan, SHI Yuangang, DAN Xingang. Research Progress of Kisspeptin/GPR54 in Mammalian Reproduction[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(10): 2341-2348.

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Research Progress of Kisspeptin/GPR54 in Mammalian Reproduction

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