Acta Veterinaria et Zootechnica Sinica ›› 2020, Vol. 51 ›› Issue (3): 433-442.doi: 10.11843/j.issn.0366-6964.2020.03.004

• REVIEW • Previous Articles     Next Articles

Nebovirus: a Diarrhea-causing Virus in Calves

GUO Zijing1, HE Qifu1, YUE Hua1,2, TANG Cheng1,2*   

  1. 1. College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China;
    2. Innovation Team for Animal Epidemic Diseases Prevention and Control on Qinghai-Tibet Plateau, State Ethnic Affairs Commission, Chengdu 610041, China
  • Received:2019-09-02 Online:2020-03-25 Published:2020-03-20

Abstract: Newbury-1 virus, usually designated by Nebovirus (NeV), is the only member of the genus Nebovirus in the family Caliciviridae at present. NeV is a single-stranded positive-sense RNA virus with a genome length of 7 453-7 460 bp and is an important diarrhea-causing virus in calves. The detection of NeV mainly relies on RT-PCR and Real-time RT-PCR assays. To date, NeV has been detected in 13 countries including the USA, the UK, Brazil, Turkey, etc., suggesting that NeV has been widely distributed around the world. Recently, our studies suggested that the virus has been widely circulating among dairy cows and yak in China, presenting a unique evolution trend, and new genotypes have been determined. To provide a reference for NeV research, this review describes the latest research progress on NeV, including the biological characteristics, epidemiology, clinical symptoms and pathology, detection methods, prevention and control.

Key words: Nebovirus, calves diarrhea, etiology, epidemiology, detection

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