嵴病毒的研究进展

doi:10.11843/j.issn.0366-6964.2023.03.005

Abstract

Abstract: Kobuvirus (KoV) is a single-stranded, positive-sense RNA virus in a new genus of the picornavirus family and currently includes 6 species of Aichivirus A-F. KoV can infect humans and animals through direct or indirect contact. The main clinical symptom of infected animals is diarrhea. The virus is widely distributed all over the world. To date, KoV has been detected in 17 countries including the USA, China, Japan, Pakistan, Brazil, Germany, France, Tunisia, etc., suggesting that KoV has been widely distributed around the world. Recently, our studies suggested that the virus has been widely circulating among goats and sheep in China, presenting a unique evolution trend, and new genotypes have been determined. To provide a reference for KoV research, this review describes the latest research progress on KoV, including the genome structure and its coding protein, epidemiology, biological characteristics, pathogenesis and detection methods.

Key words: kobuvirus, etiology, diarrhea, epidemiology, detection technology

CLC Number:

S852.659.6

ABI-kehamo, TANG Cheng, YANG Chen, YANG Falong. Research Advances in Kobuvirus[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 900-913.

References 121

[1]	KANG S, KIM Y C. Genome-based virus taxonomy with the ICTV database extension[J]. Genomics Inform, 2018, 16(4):e22.
[2]	YAMASHITA T, KOBAYASHI S, SAKAC K, et al. Isolation of cytopathic small round viruses with BS-C-1 cells from patients with gastroenteritis[J]. J Infect Dis, 1991, 164(5):954-957.
[3]	REUTER G, BOLDIZSÁRÁ, PANKOVICS P. Complete nucleotide and amino acid sequences and genetic organization of porcine kobuvirus, a member of a new species in the genus Kobuvirus, family Picornaviridae[J]. Arch Virol, 2009, 154(1):101-108.
[4]	OEM J K, LEE M H, LEE K K, et al. Novel Kobuvirus species identified from black goat with diarrhea[J]. Vet Microbiol, 2014, 172(3-4):563-567.
[5]	KITAJIMA M, GERBA C P. Aichi virus 1:environmental occurrence and behavior[J]. Pathogens, 2015, 4(2):256-268.
[6]	REUTER G, BOROSÁ, PANKOVICS P. Kobuviruses-a comprehensive review[J]. Rev Med Virol, 2011, 21(1):32-41.
[7]	WANG L Y, FREDRICKSON R, DUNCAN M, et al. Bovine kobuvirus in calves with diarrhea, United States[J]. Emerg Infect Dis, 2020, 26(1):176-178.
[8]	YANG F, LIU X W, ZHOU Y C, et al. Histopathology of Porcine kobuvirus in Chinese piglets[J]. Virol Sin, 2015, 30(5):396-399.
[9]	RIVADULLA E, VARELA M F, ROMALDE J L. Epidemiology of Aichi virus in fecal samples from outpatients with acute gastroenteritis in Northwestern Spain[J]. J Clin Virol, 2019, 118:14-19.
[10]	RIVADULLA E, ROMALDE J L. A comprehensive review on human Aichi virus[J]. Virol Sin, 2020, 35(5):501-516.
[11]	HAO L L, CHEN C X, BAILEY K, et al. Bovine kobuvirus-A comprehensive review[J]. Transbound Emerg Dis, 2021, 68(4):1886-1894.
[12]	CHEN Y S, CHEN B C, LIN Y S, et al. Detection of Aichi virus with antibody targeting of conserved viral protein 1 epitope[J]. Appl Microbiol Biotechnol, 2013, 97(19):8529-8536.
[13]	ZHANG M D, HILL J E, ALEXANDER T W, et al. The nasal viromes of cattle on arrival at western Canadian feedlots and their relationship to development of bovine respiratory disease[J]. Transbound Emerg Dis, 2021, 68(4):2209-2218.
[14]	LIU P J, LI P, LYU W T, et al. Epidemiological study and variation analysis of the porcine kobuvirus 3D gene in Sichuan province, China[J]. Virol Sin, 2015, 30(6):460-463.
[15]	DI MARTINO B, DI PROFIO F, MELEGARI I, et al. Detection of feline kobuviruses in diarrhoeic cats, Italy[J]. Vet Microbiol, 2015, 176(1-2):186-189.
[16]	KONG N, ZUO Y W, WANG Z Z, et al. Molecular characterization of new described kobuvirus in dogs with diarrhea in China[J]. Springerplus, 2016, 5(1):2047.
[17]	ABI K M, ZHANG Q, JING Z Z, et al. First detection and molecular characteristics of caprine kobuvirus in goats in China[J]. Infect Genet Evol, 2020, 85:104566.
[18]	ABI K M, YU Z H, JING Z Z, et al. Identification of a novel Aichivirus D in sheep[J]. Infect Genet Evol, 2021, 91:104810.
[19]	ABI K M, YANG C, TANG C, et al. Aichivirus C isolate is a diarrhoea‐causing pathogen in goats[J]. Transbound Emerg Dis, 2022, 69(5):e2268-e2275.
[20]	周秀蓉,肖霜艳,康桦华,等.动物库布病毒研究进展[J].中国动物保健, 2019, 21(11):48-51, 53.ZHOU X R, XIAO S Y, KANG H H, et al. Research advances in kobuvirus[J]. China Animal Health, 2019, 21(11):48-51, 53.(in Chinese)
[21]	OTOMARU K, NAOI Y, HAGA K, et al. Detection of novel kobu-like viruses in Japanese black cattle in Japan[J]. J Vet Med Sci, 2016, 78(2):321-324.
[22]	SMITS S L, RAJ V S, ODUBER M D, et al. Metagenomic analysis of the ferret fecal viral flora[J]. PLoS One, 2013, 8(8):e71595.
[23]	SASAKI J, NAGASHIMA S, TANIGUCHI K. Aichi virus leader protein is involved in viral RNA replication and encapsidation[J]. J Virol, 2003, 77(20):10799-10807.
[24]	YAMASHITA T, SAKAE K, TSUZUKI H, et al. Complete nucleotide sequence and genetic organization of Aichi virus, a distinct member of the Picornaviridae associated with acute gastroenteritis in humans[J]. J Virol, 1998, 72(10):8408-8412.
[25]	HELLEN C U T, WIMMER E. Maturation of poliovirus capsid proteins[J]. Virology, 1992, 187(2):391-397.
[26]	KLIMA M, CHALUPSKA D, RÓŻYCKI B, et al. Kobuviral non-structural 3A proteins act as molecular harnesses to hijack the host ACBD3 protein[J]. Structure, 2017, 25(2):219-230.
[27]	ISHIKAWA-SASAKI K, NAGASHIMA S, TANIGUCHI K, et al. Model of OSBP-mediated cholesterol supply to Aichi virus RNA replication sites involving protein-protein interactions among viral proteins, ACBD3, OSBP, VAP-A/B, and SAC1[J]. J Virol, 2018, 92(8):e01952-17.
[28]	ZHU L, WANG X X, REN J S, et al. Structure of human Aichi virus and implications for receptor binding[J]. Nat Microbiol, 2016, 1(11):16150.
[29]	JIANG P, LIU Y, MA H C, et al. Picornavirus morphogenesis[J]. Microbiol Mol Biol Rev, 2014, 78(3):418-437.
[30]	SABIN C, FÜZIK T,ŠKUBNÍK K, et al. Structure of Aichi virus 1 and its empty particle:clues to kobuvirus genome release mechanism[J]. J Virol, 2016, 90(23):10800-10810.
[31]	ADZHUBEI A A, STERNBERG M J E, MAKAROV A A. Polyproline-II helix in proteins:structure and function[J]. J Mol Biol, 2013, 425(12):2100-2132.
[32]	PENG Q Q, LAN X, WANG C, et al. Kobuvirus VP3 protein restricts the IFN-β-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation[J]. Virology, 2017, 507:161-169.
[33]	LUKASHEV A N, DREXLER J F, BELALOV I S, et al. Genetic variation and recombination in Aichi virus[J]. J Gen Virol, 2012, 93(6):1226-1235.
[34]	JACKSON T, SHEPPARD D, DENYER M, et al. The epithelial integrin αvβ6 is a receptor for foot-and-mouth disease virus[J]. J Virol, 2000, 74(11):4949-4956.
[35]	YUAN S, CAO L, LING H, et al. TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope[J]. Protein Cell, 2015, 6(11):814-824.
[36]	BARANOWSKI E, RUIZ-JARABO C M, SEVILLA N, et al. Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif:flexibility in aphthovirus receptor usage[J]. J Virol, 2000, 74(4):1641-1647.
[37]	WILLIAMS C, H, KAJANDER T, HYYPIAÄ T, et al. Integrin αvβ6 is an RGD-dependent receptor for coxsackievirus A9[J]. J Virol, 2004, 78(13):6967-6973.
[38]	王玮.山东省猪嵴病毒的流行病学调查及其VP1基因的遗传分析[D].泰安:山东农业大学, 2018.WANG W. Epidemiological investigation of porcine kobuvirus in Shandong province and genetic analysis of VP1 gene[D]. Taian:Shandong Agricultural University, 2018.(in Chinese)
[39]	OH D Y, SILVA P A, HAUROEDER B, et al. Molecular characterization of the first Aichi viruses isolated in Europe and in South America[J]. Arch Virol, 2006, 151(6):1199-1206.
[40]	PHAM N T, KHAMRIN P, NGUYEN T A, et al. Isolation and molecular characterization of aichi viruses from fecal specimens collected in Japan, Bangladesh, Thailand, and Vietnam[J]. J Clin Microbiol, 2007, 45(7):2287-2288.
[41]	SHI D, ZHANG S, CHEN J F, et al. Molecular characterization of a porcine kobuvirus variant strain in China[J]. Arch Virol, 2013, 158(11):2379-2383.
[42]	YAMASHITA T, SAKAE K, KOBAYASHI S, et al. Isolation of cytopathic small round virus (Aichi virus) from Pakistani children and Japanese travelers from southeast Asia[J]. Microbiol Immunol, 1995, 39(6):433-435.
[43]	LI H P, TANG C, YUE H. Molecular detection and genomic characteristics of bovine kobuvirus from dairy calves in China[J]. Infect Genet Evol, 2019, 74:103939.
[44]	GOYER M, AHO L S, BOUR J B, et al. Seroprevalence distribution of Aichi virus among a French population in 2006-2007[J]. Arch Virol, 2008, 153(6):1171-1174.
[45]	RIBES J M, MONTAVA R, TÉLLEZ-CASTILLO C J, et al. Seroprevalence of Aichi virus in a Spanish population from 2007 to 2008[J]. Clin Vaccine Immunol, 2010, 17(4):545-549.
[46]	KAPOOR A, SIMMONDS P, DUBOVI E J, et al. Characterization of a canine homolog of human aichivirus[J]. J Virol, 2011, 85(21):11520-11525.
[47]	CARMONA-VICENTE N, BUESA J, BROWN P A, et al. Phylogeny and prevalence of kobuviruses in dogs and cats in the UK[J]. Vet Microbiol, 2013, 164(3-4):246-252.
[48]	CHOI S, LIM S I, KIM Y K, et al. Phylogenetic analysis of astrovirus and kobuvirus in Korean dogs[J]. J Vet Med Sci, 2014, 76(8):1141-1145.
[49]	LI C Q, WEI S, GUO D H, et al. Prevalence and phylogenetic analysis of canine kobuviruses in diarrhoetic dogs in northeast China[J]. J Vet Med Sci, 2016, 78(1):7-11.
[50]	LI M X, YAN N, WANG M, et al. Prevalence and genomic characteristics of canine kobuvirus in southwest China[J]. Arch Virol, 2018, 163(2):459-466.
[51]	MELEGARI I, SARCHESE V, DI PROFIO F, et al. First molecular identification of kobuviruses in wolves (Canis lupus) in Italy[J]. Arch Virol, 2018, 163(2):509-513.
[52]	DI MARTINO B, DI FELICE E, CECI C, et al. Canine kobuviruses in diarrhoeic dogs in Italy[J]. Vet Microbiol, 2013, 166(1-2):246-249.
[53]	CHUNG J Y, KIM S H, KIM Y H, et al. Detection and genetic characterization of feline kobuviruses[J]. Virus Genes, 2013, 47(3):559-562.
[54]	NIU T J, YI S S, WANG X, et al. Detection and genetic characterization of kobuvirus in cats:the first molecular evidence from Northeast China[J]. Infect Genet Evol, 2019, 68:58-67.
[55]	LU G, ZHANG X, LUO J, et al. First report and genetic characterization of feline kobuvirus in diarrhoeic cats in China[J]. Transbound Emerg Dis, 2018, 65(5):1357-1363.
[56]	PHAN T G, KAPUSINSZKY B, WANG C L, et al. The fecal viral flora of wild rodents[J]. PLoS Pathog, 2011, 7(9):e1002218.
[57]	LU L, VAN DUNG N, IVENS A, et al. Genetic diversity and cross-species transmission of kobuviruses in Vietnam[J]. Virus Evol, 2018, 4(1):vey002.
[58]	WILLIAMS S H, CHE X Y, GARCIA J A, et al. Viral diversity of house mice in New York City[J]. mBio, 2018, 9(2):e01354-17.
[59]	YOU F F, ZHANG M Y, HE H, et al. Kobuviruses carried by Rattus norvegicus in Guangdong, China[J]. BMC Microbiol, 2020, 20(1):94.
[60]	ZHANG M Y, YOU F F, WU F, et al. Epidemiology and genetic characteristics of murine kobuvirus from faecal samples of Rattus losea, Rattus tanezumi and Rattus norvegicus in southern China[J]. J General Virol, 2021, 102(9):001646.
[61]	PANKOVICS P, BOROSÁ, KISS T, et al. Identification and complete genome analysis of kobuvirus in faecal samples of European roller (Coracias garrulus):for the first time in a bird[J]. Arch Virol, 2015, 160(1):345-351.
[62]	DI PROFIO F, CECI C, DI FELICE E, et al. Molecular detection of porcine kobuviruses in Italian swine[J]. Res Vet Sci, 2013, 95(2):782-785.
[63]	KITAJIMA M, HATA A, YAMASHITA T, et al. Development of a reverse transcription-quantitative PCR system for detection and genotyping of Aichi viruses in clinical and environmental samples[J]. Appl Environ Microbiol, 2013, 79(13):3952-3958.
[64]	KITAJIMA M, HARAMOTO E, PHANUWAN C, et al. Prevalence and genetic diversity of Aichi viruses in wastewater and river water in Japan[J]. Appl Environ Microbiol, 2011, 77(6):2184-2187.
[65]	THONGPRACHUM A, FUJIMOTO T, TAKANASHI S, et al. Detection of nineteen enteric viruses in raw sewage in Japan[J]. Infect Genet Evol, 2018, 63:17-23.
[66]	BETANCOURT W Q, KITAJIMA M, WING A D, et al. Assessment of virus removal by managed aquifer recharge at three full-scale operations[J]. J Environ Sci Health, Part A, 2014, 49(14):1685-1692.
[67]	CHANG J T, WANG Q, WANG F, et al. Prevalence and genetic diversity of bovine kobuvirus in China[J]. Arch Virol, 2014, 159(6):1505-1510.
[68]	MOHAMED F F, MANSOUR S M G, ORABI A, et al. Detection and genetic characterization of bovine kobuvirus from calves in Egypt[J]. Arch Virol, 2018, 163(6):1439-1447.
[69]	YAMASHITA T, ITO M, KABASHIMA Y, et al. Isolation and characterization of a new species of kobuvirus associated with cattle[J]. J Gen Virol, 2003, 84(11):3069-3077.
[70]	CANDIDO M, BATINGA M C A, ALENCAR A L F, et al. Molecular characterization and genetic diversity of bovine Kobuvirus, Brazil[J]. Virus Genes, 2017, 53(1):105-110.
[71]	PARK S J, KIM H K, SONG D S, et al. Molecular detection and genetic characterization of kobuviruses in fecal samples collected from diarrheic cattle in Korea[J]. Infect Genet Evol, 2011, 11(5):1178-1182.
[72]	JEOUNG H Y, LIM J A, JEONG W, et al. Three clusters of bovine kobuvirus isolated in Korea, 2008-2010[J]. Virus Genes, 2011, 42(3):402-406.
[73]	REUTER G, BOROSÁ, PANKOVICS P, et al. Kobuvirus in domestic sheep, hungary[J]. Emerg Infect Dis, 2010, 16(5):869-870.
[74]	BARRY A F, RIBEIRO J, ALFIERI A F, et al. First detection of kobuvirus in farm animals in Brazil and the Netherlands[J]. Infect Genet Evol, 2011, 11(7):1811-1814.
[75]	REUTER G, BOLDIZSÁRÁ, KISS I, et al. Candidate new species of Kobuvirus in porcine hosts[J]. Emerg Infect Dis, 2008, 14(12):1968-1970.
[76]	VERMA H, MOR S K, ABDEL-GLIL M Y, et al. Identification and molecular characterization of porcine kobuvirus in U. S. swine[J]. Virus Genes, 2013, 46(3):551-553.
[77]	YU J M, DUAN Z J, ZHANG Q, et al. Candidate porcine Kobuvirus, China[J]. Emerg Infect Dis, 2009, 15(5):823-825.
[78]	韩磊.河北省猪嵴病毒流行情况调查及检测方法的建立[D].保定:河北农业大学, 2021.HAN L. Epidemic investigation and establishment of assays for detection of porcine kobuvirus in Hebei Province[D]. Baoding:Hebei Agricultural University, 2021.(in Chinese)
[79]	WANG C, LAN X, YANG B. Molecular epidemiological investigation of Porcine kobuvirus and its coinfection rate with PEDV and SaV in Northwest China[J]. Biomed Res Int, 2016, 2016:7590569.
[80]	ZHAO Z P, YANG Z, LIN W D, et al. The rate of co-infection for piglet diarrhea viruses in China and the genetic characterization of porcine epidemic diarrhea virus and porcine kobuvirus[J]. Acta Virol, 2016, 60(1):55-61.
[81]	WANG C, LAN X, YANG B. Corrigendum to "Molecular epidemiological investigation of Porcine kobuvirus and its coinfection rate with PEDV and SaV in Northwest China" [J]. Biomed Res Int, 2017, 2017:9794340.
[82]	LU L, VAN DUNG N, BRYANT J E, et al. Evolution and phylogeographic dissemination of endemic porcine picornaviruses in Vietnam[J]. Virus Evol, 2016, 2(1):vew001.
[83]	REUTER G, KECSKEMÉTI S, PANKOVICS P. Evolution of porcine kobuvirus infection, Hungary[J]. Emerg Infect Dis, 2010, 16(4):696-698.
[84]	胡军勇,汤细彪,胡睿铭,等.猪库布病毒RT-PCR检测方法的建立及湖北省流行病学初步调查[J].华中农业大学学报, 2012, 31(4):485-489.HU J Y, TANG X B, HU R M, et al. Porcine kobuvirus RT-PCR detection assay establishment and application in primary epidemiology investigation in Hubei Province[J]. Journal of Huazhong Agricultural University, 2012, 31(4):485-489.(in Chinese)
[85]	CHEN L, ZHU L, ZHOU Y C, et al. Molecular and phylogenetic analysis of the porcine kobuvirus VP1 region using infected pigs from Sichuan Province, China[J]. Virol J, 2013, 10:281.
[86]	REUTER G, NEMES C, BOROSÁ, et al. Porcine kobuvirus in wild boars (Sus scrofa)[J]. Arch Virol, 2013, 158(1):281-282.
[87]	田野.猪嵴病毒VP1基因克隆与表达及抗体检测ELISA方法的建立[D].扬州:扬州大学, 2013.TIAN Y. Gene clone and prokaryotic expression of structural protein VP1 of porcine kobuvirus and development of ELISA for detection of antibody to VP1[D]. Yangzhou:Yangzhou University, 2013.(in Chinese)
[88]	朱庆贺,苗艳,李文辉,等.猪嵴病毒重组VP3蛋白间接ELISA检测方法的建立[J].中国兽医科学, 2017, 47(9):1150-1153.ZHU Q H, MIAO Y, LI W H, et al. Establishment of an indirect ELISA based on VP3 protein for the detection of the antibodies against porcine kobuvirus[J]. Chinese Veterinary Science, 2017, 47(9):1150-1153.(in Chinese)
[89]	LEE M H, JEOUNG H Y, LIM J A, et al. Kobuvirus in South Korean black goats[J]. Virus Genes, 2012, 45(1):186-189.
[90]	DI MARTINO B, DI PROFIO F, MELEGARI I, et al. Molecular detection of kobuviruses in European roe deer (Capreolus capreolus) in Italy[J]. Arch Virol, 2015, 160(8):2083-2086.
[91]	MELEGARI I, DI PROFIO F, SARCHESE V, et al. First molecular evidence of kobuviruses in goats in Italy[J]. Arch Virol, 2016, 161(11):3245-3248.
[92]	SOBHY N M, ARMIÉN A G, WVNSCHMANN A, et al. Detection and molecular characterization of kobuvirus from diarrheic goats in Minnesota[J]. J Vet Diagn Invest, 2020, 32(6):873-879.
[93]	阿比克哈莫,余忠华,景志忠,等.检测山羊嵴病毒的实时荧光定量PCR方法的建立和应用[J].畜牧兽医学报, 2021, 52(5):1349-1358.ABI-KEHAMO, YU Z H, JING Z Z, et al. Establishment and application of a real time fluorescent quantitative PCR assay for detecting caprine kobuvirus[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(5):1349-1358.(in Chinese)
[94]	PANKOVICS P, BOROSÁ, BÍRÓ H, et al. Novel picornavirus in domestic rabbits (Oryctolagus cuniculus var. domestica)[J]. Infect Genet Evol, 2016, 37:117-122.
[95]	WU Z Q, YANG L, REN X W, et al. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases[J]. ISME J, 2016, 10(3):609-620.
[96]	CROMEANS T, PARK G W, COSTANTINI V, et al. Comprehensive comparison of cultivable norovirus surrogates in response to different inactivation and disinfection treatments[J]. Appl Environ Microbiol, 2014, 80(18):5743-5751.
[97]	SEWLIKAR S, D'SOUZA D H. Survival of hepatitis A virus and Aichi virus in cranberry-based juices at refrigeration (4℃)[J]. Food Microbiol, 2017, 62:251-255.
[98]	DI MARTINO B, DI PROFIO F, MELEGARI I, et al. Molecular evidence of kobuviruses in free-ranging red foxes (Vulpes vulpes)[J]. Arch Virol, 2014, 159(7):1803-1806.
[99]	OLARTE-CASTILLO X A, HEEGER F, MAZZONI C J, et al. Molecular characterization of canine kobuvirus in wild carnivores and the domestic dog in Africa[J]. Virology, 2015, 477:89-97.
[100]	KHAMRIN P, MANEEKARN N, HIDAKA S, et al. Molecular detection of kobuvirus sequences in stool samples collected from healthy pigs in Japan[J]. Infect Genet Evol, 2010, 10(7):950-954.
[101]	PORTES S A R, DE MELLO VOLOTÃO E, ROSE T L, et al. Aichi virus positivity in HIV-1 seropositive children hospitalized with diarrheal disease[J]. Curr HIV Res, 2015, 13(4):325-331.
[102]	BUCCIOL G, MOENS L, PAYNE K, et al. Chronic Aichi virus infection in a patient with X-linked agammaglobulinemia[J]. J Clin Immunol, 2018, 38(7):748-752.
[103]	DUFKOVA L, SCIGALKOVA I, MOUTELIKOVA R, et al. Genetic diversity of porcine sapoviruses, kobuviruses, and astroviruses in asymptomatic pigs:an emerging new sapovirus GIII genotype[J]. Arch Virol, 2013, 158(3):549-558.
[104]	JACKOVA A, SLIZ I, MANDELIK R, et al. Porcine kobuvirus 1 in healthy and diarrheic pigs:genetic detection and characterization of virus and co-infection with rotavirus A[J]. Infect Genet Evol, 2017, 49:73-77.
[105]	CARTER M J. Enterically infecting viruses:pathogenicity, transmission and significance for food and waterborne infection[J]. J Appl Microbiol, 2005, 98(6):1354-1380.
[106]	YAMASHITA T, ITO M, TSUZUKI H, et al. Identification of Aichi virus infection by measurement of immunoglobulin responses in an enzyme-linked immunosorbent assay[J]. J Clin Microbiol, 2001, 39(11):4178-4180.
[107]	DI MARTINO B, DI PROFIO F, ROBETTO S, et al. Molecular survey on kobuviruses in domestic and wild ungulates from northwestern Italian alps[J]. Front Vet Sci, 2021, 8:679337.
[108]	LI Y, LIANG J X, WU S M, et al. Complete genomic sequence analysis and intestinal tissue localization of a porcine Kobuvirus variant in China[J]. Infect Genet Evol, 2022, 104:105362.
[109]	FAUQUET C M, MAYO M A, MANILOFF J, et al. Virus taxonomy:classification and nomenclature of viruses eighth report of the international committee on taxonomy of viruses[M]. London:Academic Press, 2005.
[110]	林雨晨.猪嵴病毒WUH1株全基因组序列分析及病毒的分离[D].武汉:华中农业大学, 2013.LIN Y C. Analysis of complete genome sequence of porcine Kobuvirus WUH1 strain and isolation of porcine Kobuvirus[D]. Wuhan:Huazhong Agricultural University, 2013.(in Chinese)
[111]	GARCÍA-HERNÁNDEZ M E, TRUJILLO-ORTEGA M E, ALCARAZ-ESTRADA S L, et al. Molecular detection and characterization of porcine epidemic diarrhea virus and porcine aichivirus C coinfection in México[J]. Viruses, 2021, 13(5):738.
[112]	YAMASHITA T, SUGIYAMA M, TSUZUKI H, et al. Application of a reverse transcription-PCR for identification and differentiation of Aichi virus, a new member of the picornavirus family associated with gastroenteritis in humans[J]. J Clin Microbiol, 2000, 38(8):2955-2961.
[113]	刘孟良,王潇娣,徐薇薇,等.猪嵴病毒SYBR Green Ⅰ实时荧光定量PCR检测方法的建立[J].中国兽医科学, 2013, 43(3):261-265.LIU M L, WANG X D, XU W W, et al. Development of a real-time fluorescent quantitative PCR assay for the detection of porcine kobuvirus[J]. Chinese Veterinary Science, 2013, 43(3):261-265.(in Chinese)
[114]	谢荣辉,刘霞,赵灵燕,等.猪嵴病毒荧光定量RT-PCR检测方法的建立和应用[J].中国兽医科学, 2018, 48(4):438-442.XIE R H, LIU X, ZHAO L Y, et al. Establishment and application of the real-time reverse transcription polymerase chain reaction for detection of porcine kobuvirus[J]. Chinese Veterinary Science, 2018, 48(4):438-442.(in Chinese)
[115]	LODDER W J, RUTJES S A, TAKUMI K, et al. Aichi virus in sewage and surface water, the Netherlands[J]. Emerg Infect Dis, 2013, 19(8):1222-1230.
[116]	李慧平,汤承,岳华.实时荧光定量RT-PCR检测牛库布病毒[J].畜牧兽医学报, 2020, 51(4):888-893.LI H P, TANG C, YUE H. Development and application of a real-time RT-PCR assay for detecting bovine kobuvirus[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(4):888-893.(in Chinese)
[117]	PHAM N T K, TRINH Q D, NGUYEN T A, et al. Development of genotype-specific primers for differentiation of genotypes A and B of Aichi viruses[J]. J Virol Methods, 2009, 156(1-2):107-110.
[118]	VILAS BOAS L C P, DE LIMA L M P, MIGLIOLO L, et al. Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus[J]. Pept Sci, 2017, 108(2):e22871.
[119]	AILAVADI S, MORGAN M T, D'SOUZA D H. Aichi virus inactivation by heat in 2-ml glass vials[J]. J Food Sci, 2021, 86(9):4110-4118.
[120]	王琛.猪嵴病毒分子流行病学及防制技术研究[D].北京:中国农业科学院, 2016.WANG C. Molecular epidemiology of porcine kobuvirus and its prevention and control technology[D]. Beijing:Chinese Academy of Agricultural Sciences, 2016.(in Chinese)
[121]	VALENTI W M, HRUSKA J F, MENEGUS M A, et al. Nosocomial viral infections:III. guidelines for prevention and control of exanthematous viruses, gastroenteritis viruses, picornaviruses, and uncommonly seen viruses[J]. Infect Control, 1981, 2(1):38-49.

Research Advances in Kobuvirus

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