白消安对睾丸的毒害作用及机制探讨

doi:10.11843/j.issn.0366-6964.2020.03.003

Abstract

Abstract: Busulfan has high toxic effect on the spermatogenesis and can cause male sterility. It is an ideal agent for the preparation of transplant recipients of spermatogonial stem cells (SSCs). Orchitis also has an important effect on the spermatogenic function and can even lead to male sterility. However, the mechanism by which busulfan damages the blood-testis barrier (BTB) and affects spermatogenesis is unclear. It is unknown whether it will cause non-infectious testicular inflammation, affect cytokine secretion, and impair fertility. Therefore, the damage effect of busulfan on the BTB, its effects on testicular cell-related functional proteins, and the relief methods of busulfan-damaged testis are summerized in this review. It deeply reveals the toxic effect of busulfan on the function and structure of testicular cells and BTB. Furthermore, we provide theoretical guidance for the efficient and safe preparation of SSCs transplantation recipients, and protection and recovery of male spermatozoa under the action of therapeutic and environmental toxins.

Key words: busulfan, blood-testis barrier, inflammation, cytokine

CLC Number:

S821.3

LI Ruyi, MENGAL Kifayatullah, CHEN Xiaoli, WANG Dong. Study on the Toxic Effect and Mechanism of Busulfan on Testis[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 426-432.

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Study on the Toxic Effect and Mechanism of Busulfan on Testis

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