β-羟丁酸介导的表观遗传修饰及其调节炎症反应分子机制研究进展

doi:10.11843/j.issn.0366-6964.2023.10.009

Abstract

Abstract: Dairy cows experience varying degrees of negative energy balance during the perinatal period. Severe negative energy balance leads to ketosis, abnormally elevated blood ketone body concentration, reduced performance, and often inflammatory diseases in dairy cows. β-hydroxybutyrate (BHBA) is a major ketone molecule. BHBA not only acts as an energy source, but also mediates epigenetic modifications that regulate gene transcription and expression, and can act as a signaling molecule that binds to the corresponding receptor to regulate the inflammatory response. BHBA links changes in the external environment to changes in cell function and affects disease processes. This review of BHBA signal transduction focuses on the effect of BHBA on epigenetic modification to alter gene transcription regulation, and explores the molecular mechanisms of BHBA in the regulation of inflammatory response, with the aim of providing new ideas for the study of metabolism and inflammation.

Key words: β-hydroxybutyrate, epigenetic modification, inflammation, metabolism

CLC Number:

S852.2

DAI Lingli, LIU Zaixia, GUO Lili, YANG Yanda, CHANG Chencheng, WANG Yu, SHI Caixia, WANG Yuzhen, ZHANG Wenguang. β-Hydroxybutyrate Mediated Epigenetic Modification and Its Molecular Mechanism of Regulating Inflammation[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4095-4104.

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β-Hydroxybutyrate Mediated Epigenetic Modification and Its Molecular Mechanism of Regulating Inflammation

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