靶向抗菌肽的设计策略与应用

doi:10.11843/j.issn.0366-6964.2020.02.005

Abstract

Abstract: The discovery of antibiotics has saved countless lives. However, the emergence of multidrug-resistant bacteria and ecological imbalance of normal microbial communities due to indiscriminate use of antibiotics has forced on finding effective substitutions of antibiotics. Antimicrobial peptides (AMPs) exist widely in animals and plants, which have effective activity against bacteria, tumor, virus etc., without inducing drug resistance. It has excellent application prospects in clinical and livestock industry. In order to avoid problems such as drug resistance and micro-ecological disorders, targeted antimicrobial peptides have aroused researchers' interests and gradually become a research hotspot, which have been expected as one of the effective substitutions of antibiotics. In this paper, the design ideas of targeted antimicrobial peptides in recent years and their application prospects in clinical and animal husbandry are summarized, in order to provide new ideas for the development of targeted antimicrobial peptides in the future.

Key words: targeted antimicrobial peptides, design strategy, micro-ecological balance

CLC Number:

S852.4

LI Qiuke, LI Jinze, WU Hua, CHOU Shuli, SHAN Anshan. Design Strategy and Application on Targeted Antimicrobial Peptides[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(2): 243-251.

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Design Strategy and Application on Targeted Antimicrobial Peptides

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