热应激通过干扰生物钟系统影响反刍动物消化道屏障功能的研究进展

doi:10.11843/j.issn.0366-6964.2025.09.007

摘要/Abstract

摘要： 近年来，随着全球温室效应愈加严重，极端天气频发对畜牧业造成了巨大经济损失。尤其在热浪频发的夏季，持续高温会引起反刍动物热应激反应，导致其生长发育受阻，病死率增加，严重制约了畜牧业高质量发展。研究发现，热应激对幼龄反刍动物肠道健康的影响尤为显著，会造成肠道微生物菌群结构紊乱、氧化应激损伤和屏障通透性增加。然而，现有的研究大多只在单一时间点对热应激引发的肠道损伤进行探讨，最新研究揭示肠道屏障功能并非静态而是呈现昼夜节律性变化。为此，本文从昼夜节律尺度，综述了热应激对反刍动物消化道生物钟和屏障功能昼夜节律的影响，以期找到热应激通过生物钟调控消化道屏障功能的潜在途径及机制，为反刍动物精准生产和环境管理提供新思路。

关键词: 热应激, 生物钟, 消化道屏障

Abstract: In recent years, as the global greenhouse effect has become more serious, frequent extreme weather has caused huge economic losses to animal husbandry. Especially in the summer when heat waves are frequent, continuous high temperatures can cause heat stress reactions in ruminants, resulting in stunted growth and development, increased mortality, and serious restrictions on the high-quality development of animal husbandry. Studies have found that heat stress has a particularly significant impact on the intestinal health of young ruminants, causing disordered intestinal microbial flora structure, oxidative stress damage, and increased barrier permeability. However, most existing studies only explore intestinal damage caused by heat stress at a single time point, but the latest research reveals that intestinal barrier function is not static but shows circadian rhythmic changes. To this end, this article reviews the effects of heat stress on the circadian rhythm of the digestive tract biological clock and barrier function of ruminants on a diurnal time scale, in order to find potential pathways and mechanisms for heat stress to regulate digestive tract barrier function through the biological clock, and provide new ideas for precise production and environmental management of ruminants.

Key words: heat stress, biological clock, digestive tract barrier

中图分类号:

S815.4

易唤明, 鲍国升, 万辉, 欧靖渝, 何小龙, 任春环, 陈家宏, 张子军, 王强军. 热应激通过干扰生物钟系统影响反刍动物消化道屏障功能的研究进展[J]. 畜牧兽医学报, 2025, 56(9): 4204-4214.

YI Huanming, BAO Guosheng, WAN Hui, OU Jingyu, HE Xiaolong, REN Chunhuan, CHEN Jiahong, ZHANG Zijun, WANG Qiangjun. Research Progress of Heat Stress Affect Digestive Tract Barrier Function of Ruminants by Interfering with Biological Clock[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4204-4214.

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