Hox基因家族及其对动物脊椎形成的影响

doi:10.11843/j.issn.0366-6964.2022.04.001

摘要/Abstract

摘要： Hox基因编码保守的转录因子，它们控制发育过程中胚胎的骨骼模式。它们在受限的区域表达，并调节特定椎骨的形态。从最初在果蝇中发现该基因家族至今已有四十多年的历史。不断更新的研究使人们对Hox基因在脊椎动物中轴骨骼模式化中的作用有了新见解。本文综述了Hox基因在建立轴向形态中的遗传学和胚胎学发现,以及这些综合结果如何影响目前对脊椎动物Hox调控的理解。便于今后对动物的脊椎形态及数量变异进行研究。

关键词: Hox基因, 胚胎, 中轴骨骼, 脊椎形态

Abstract: Hox genes encode conserved transcription factors that control skeletal patterning in the developing embryo. They are expressed in restricted domains and function to regulate the morphology of specific vertebral elements. It has been more than 40 years since the gene family was first discovered in drosophila. The updated studies allow an emerging understanding of Hox genes function in patterning the vertebrate axial skeleton. This review summarizes genetic and embryologic findings regarding the role of Hox genes in establishing axial morphology and how these combined results impact the current understanding for the vertebrate Hox control, which will be of great help in studying vertebrate morphology and quantitative variation of animals.

Key words: Hox genes, embryo, axial skeleton, vertebrate morphology

中图分类号:

S813.2

李桃桃, 金美林, 费晓娟, 王慧华, 陆健, 狄冉, 魏彩虹. Hox基因家族及其对动物脊椎形成的影响[J]. 畜牧兽医学报, 2022, 53(4): 999-1009.

LI Taotao, JIN Meilin, FEI Xiaojuan, WANG Huihua, LU Jian, DI Ran, WEI Caihong. The Hox Gene Family and Its Effects on Spine Formation in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(4): 999-1009.

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