水杨酰苯胺类及咪唑并噻唑类抗寄生虫药物的理化性质及其应用研究进展

doi:10.11843/j.issn.0366-6964.2025.03.009

摘要/Abstract

摘要：

寄生虫病严重制约畜牧业的发展，由于治疗药物种类较少等问题导致耐药性严重，且治疗效果不佳，因此近年来对于有效防治寄生虫病的新型药物需求增加。针对当前现状，大量临床试验表明：将两种或多种抗寄生虫类药物联用，可能会达到增强药物利用度、扩大抗虫谱并降低寄生虫耐药性的目的。为此，将隶属于咪唑并噻唑类药物的盐酸左旋咪唑和隶属于水杨酰苯胺类药物的羟氯扎胺联合使用，可有效防治线虫病和吸虫病，其独特的作用机理引起了研究者广泛的关注。本文就这两类药物的作用机理、设计合成、理化性质、研究现状以及联合使用的疗效等进行综述。

关键词: 寄生虫, 水杨酰苯胺类, 咪唑并噻唑类, 盐酸左旋咪唑, 羟氯扎胺, 疗效

Abstract:

Parasitic diseases significantly hinder the development of animal husbandry. The limited range of therapeutic drugs has led to severe drug resistance and suboptimal treatment outcomes. Consequently, there has been an increased demand for new drugs effective in preventing and treating parasitic diseases. In response, numerous clinical trials demonstrate that combining two or more antiparasitic drugs can enhance efficacy, broaden the antiparasitic spectrum, and mitigate parasite resistance. The combination of levamisole hydrochloride, an imidazole thiazole drug, and oxyclozanide, a salicylamide drug, has proven effective in treating nematode and schistosomiasis, with its unique mechanism of action garnering extensive researcher interest. This article provides a comprehensive review of the mechanisms of action, design and synthesis, physicochemical properties, research status, and therapeutic efficacy of these dual-class drug combinations.

Key words: parasites, salicylanilines, imidazolothiazoles, levamisole hydrochloride, oxyclozanide, efficacy

中图分类号:

S859.795

代国年, 李冰, 周雅馨, 李江, 徐晶, 周绪正, 彭晓婷, 张继瑜. 水杨酰苯胺类及咪唑并噻唑类抗寄生虫药物的理化性质及其应用研究进展[J]. 畜牧兽医学报, 2025, 56(3): 1065-1075.

DAI Guonian, LI Bing, ZHOU Yaxin, LI Jiang, XU Jing, ZHOU Xuzheng, PENG Xiaoting, ZHANG Jiyu. Research Progress on The Physicochemical Properties and Applications of Salicylanilines and Imidazolothiazole Antiparasitic Drugs[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(3): 1065-1075.

图/表 6

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