犬细小病毒特异性免疫球蛋白的临床应用效果观察

doi:10.11843/j.issn.0366-6964.2021.09.032

畜牧兽医学报 ›› 2021, Vol. 52 ›› Issue (9): 2682-2686.doi: 10.11843/j.issn.0366-6964.2021.09.032

• 研究简报 • 上一篇

犬细小病毒特异性免疫球蛋白的临床应用效果观察

陈念慈¹, 王思莹², 柴鑫妍¹, 赵永¹, 杨万莲¹, 孙艳争¹, 吕艳丽^1,2*

1. 中国农业大学动物医学院, 北京 100193;
2. 中国农业大学动物医院, 北京 100193;
3. 北京宠颐生动物医院, 北京 100021;
4. 北京世纪好未来科技教育有限公司, 北京 100192

收稿日期:2021-01-03 出版日期:2021-09-23 发布日期:2021-09-26
通讯作者: 吕艳丽,主要从事犬猫传染性疾病的诊疗和防控研究,E-mail:luyanli@cau.edu.cn
作者简介:陈念慈(1995-),女,四川乐山人,硕士,主要从事小动物内科疾病研究,E-mail:niancichen@qq.com
基金资助:
国家重点研发计划（2016YFD0501002）

Observation on the Clinical Application Effect of Canine Parvovirus Specific Immunoglobulin

CHEN Nianci¹, WANG Siying², CHAI Xinyan¹, ZHAO Yong¹, YANG Wanlian¹, SUN Yanzheng¹, Lü Yanli^1,2*

1. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;
2. Veterinary Teaching Hospital of China Agricultural University, Beijing 100193, China;
3. Beijing Chongyisheng Animal Hospital, Beijing 100021, China;
4. Beijing Century TAL Education Technology Co., Ltd, Beijing 100192, China

Received:2021-01-03 Online:2021-09-23 Published:2021-09-26

摘要/Abstract

摘要： 旨在观察犬细小病毒特异性免疫球蛋白治疗犬细小病毒病的临床应用效果，本文收集了中国农业大学动物医院自2016年1月—2019年11月接治的犬细小病毒病患犬的病历资料，筛选出病历资料完整的并使用了犬细小病毒单抗或犬细小病毒特异性免疫球蛋白治疗的患犬病例进行跟踪以及回访。对收集的病例数据进行了总治愈率、各初始抗体水平的治愈率、各月龄段的治愈率和治愈病例的病程分析。结果显示，犬细小病毒特异性免疫球蛋白和犬细小病毒单克隆抗体在总治愈率、相同初始抗体水平治愈率、相同月龄段治愈率均无显著差异（P>0.05）。但使用特异性免疫球蛋白的病例痊愈时间显著低于使用单克隆抗体的病例（P=0.02<0.05）。综上表明，犬细小病毒特异性免疫球蛋白的临床应用效果良好，可为犬细小病毒病的治疗提供新的药物选择。

关键词: 犬细小病毒病, 犬细小病毒特异性免疫球蛋白, 犬细小病毒单克隆抗体, 治疗效果

Abstract: In order to explore the clinical application effect of canine parvovirus (CPV) specific immunoglobulin in the treatment of CPV disease, we collected the case records of CPV infected dogs received and treated in Animal Hospital of China Agricultural University from January 2016 to November 2019, and screened out the dogs with complete medical records and were treated with CPV monoclonal antibody or CPV specific immunoglobulin. These dogs were tracked return visit. We analyzed the total cure rate, the cure rate of each initial antibody levels and each month ages and the recovery course of those cases. The results showed that there was no significant difference between CPV specific immunoglobulin and CPV monoclonal antibody in the total cure rate and the cure rate of consistent initial antibody levels and consistent month ages (P>0.05). However, the recovery course of dogs treated with specific immunoglobulin was significantly lower than those treated with monoclonal antibody (P=0.02<0.05). The good clinical application effect of canine parvovirus specific immunoglobulin provides a new choice of drugs treating CPV disease.

Key words: canine parvovirus disease, canine parvovirus specific immunoglobulin, canine parvovirus monoclonal antibody, treatment effect

中图分类号:

S858.2925.3

陈念慈, 王思莹, 柴鑫妍, 赵永, 杨万莲, 孙艳争, 吕艳丽. 犬细小病毒特异性免疫球蛋白的临床应用效果观察[J]. 畜牧兽医学报, 2021, 52(9): 2682-2686.

CHEN Nianci, WANG Siying, CHAI Xinyan, ZHAO Yong, YANG Wanlian, SUN Yanzheng, Lü Yanli. Observation on the Clinical Application Effect of Canine Parvovirus Specific Immunoglobulin[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(9): 2682-2686.

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犬细小病毒特异性免疫球蛋白的临床应用效果观察

Observation on the Clinical Application Effect of Canine Parvovirus Specific Immunoglobulin

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