反刍动物妊娠期和泌乳期生理代谢和微生物变化及其对子代发育的影响研究进展

doi:10.11843/j.issn.0366-6964.2023.11.003

Abstract

Abstract: Metabolic and microbial homeostasis are critical for the maintenance of host health. The disruption of physiological metabolism and microbial homeostasis may be an important pathogenic factor in various metabolic disorders. The pregnancy is characterized by a series of physiologic, metabolic and microbial changes. Therefore, breeding cycles are the most sensitive periods in maternal physiology and metabolism. During this period, there are significant changes in maternal hormone levels, metabolic status, and microbial composition to fulfil the fetus’s survival in utero and the nutritional needs of subsequent lactation. In recent years, studies of physiological metabolism and microbial changes in the maternal breeding cycles have made some progress. It has been suggested that physiological metabolism and microbial changes are critical for maintaining successful pregnancy and subsequent lactation. In addition, the offspring’s growth and development, microbial colonization and immune system maturation are also susceptible to maternal physiological metabolism and microbial changes. This review summarizes the changes in ruminant physiological metabolism and microorganisms during gestation and lactation and their effects on offspring growth and development, microbial colonization, and the immune system. The aim is to provide new insights into the basic mechanisms of ruminant physiological adaptation and progeny development during gestation and lactation.

Key words: maternal physiological metabolism, hormones, microorganisms, progeny development, gestation period, lactation period, ruminant

CLC Number:

S814

DU Haidong, NA Renhua. Research Progress on Physiological Metabolism and Microbial Changes of Ruminants During Gestation and Lactation and Their Effects on Offspring Development[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4458-4467.

References 89

[1]	SHAGANA J A,DHANRAJ M,JAIN A R,et al.Physiological changes in pregnancy[J].Drug Invent Today,2018,10(8):1594-1597.
[2]	NEUMAN H,KOREN O.The pregnancy microbiome[J].Nestle Nutr Inst Workshop Ser,2017,88:1-9.
[3]	ZAKARIA Z Z,AL-RUMAIHI S,AL-ABSI R S,et al.Physiological changes and interactions between microbiome and the host during pregnancy[J].Front Cell Infect Microbiol,2022,12:824925.
[4]	成传尚.妊娠期功能性日粮纤维对母猪围产期代谢综合征和仔猪肠道发育的作用及其机制[D].武汉:华中农业大学,2019.CHENG C S.Effect and mechanism of functional dietary fiber during pregnancy on perinatal metabolic syndrome in sows and intestinal development in piglets[D].Wuhan:Huazhong Agricultural University,2019.(in Chinese)
[5]	JOO E H,KIM Y R,KIM N,et al.Effect of endogenic and exogenic oxidative stress triggers on adverse pregnancy outcomes:preeclampsia,fetal growth restriction,gestational diabetes mellitus and preterm birth[J].Int J Mol Sci,2021,22(18):10122.
[6]	FOTAKIS C,MOROS G,KONTOGEORGOU A,et al.Uncontrolled thyroid during pregnancy alters the circulative and exerted metabolome[J].Int J Mol Sci,2022,23(8):4248.
[7]	GATFORD K L,MOHAMMAD S N B,HARLAND M L,et al.Impaired β-cell function and inadequate compensatory increases in β-cell mass after intrauterine growth restriction in sheep[J].Endocrinology,2008,149(10):5118-5127.
[8]	ADHIKARI B,LEE C N,KHADKA V S,et al.RNA-sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy[J].BMC Genomics,2022,23(1):494.
[9]	KAIKO G E,HORVAT J C,BEAGLEY K W,et al.Immunological decision-making:how does the immune system decide to mount a helper T-cell response?[J].Immunology,2008,123(3):326-338.
[10]	CHANEY H L,GROSE L F,LABARBARA J M,et al.Galectin-1 induces gene and protein expression related to maternal-conceptus immune tolerance in bovine endometrium[J].Biol Reprod,2022,106(3):487-502.
[11]	DONG L Y,BAI Q B,SONG W S,et al.Abnormal expression of galectin-1,-3 leading to unexplained infertility by decreasing endometrial receptivity:a retrospective analysis[J].Am J Transl Res,2023,15(1):493-501.
[12]	HAN J,YOO I,LEE S,et al.Interleukin-10 and its receptors at the maternal-conceptus interface:expression,regulation,and implication for t helper 2 cytokine predominance and maternal immune tolerance in the pig,a true epitheliochorial placentation species[J].Biol Reprod,2022,106(6):1159-1174.
[13]	XIAO Y,HUANG Y,JIANG J P,et al.Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer[J].Hereditas,2023,160(1):2.
[14]	LEBER A,TELES A,ZENCLUSSEN A C.REVIEW ARTICLE:regulatory T cells and their role in pregnancy[J].Am J Reprod Immunol,2010,63(6):445-459.
[15]	秦雪,沙懿文,杨梦豪,等.非编码RNA调控哺乳动物子宫内膜容受性和蜕膜化的研究进展[J].畜牧兽医学报,2023,54(4): 1347-1358.QIN X,SHA Y W,YANG M H,et al.Advances in regulation of non-coding RNA on mammalian endometrial receptivity and decidualization[J].Acta Veterinaria et Zootechnica Sinica,2023,54(4):1347-1358.(in Chinese)
[16]	刘爱.BCL2L15调控山羊子宫内膜容受性的作用及机制[D].武汉:华中农业大学,2021.LIU A.The role and mechanism of BCL2L15 in regulating goats endometrial receptivity[D].Wuhan:Huazhong Agricultural University,2021.(in Chinese)
[17]	STEINHAUSER C B,ASKELSON K,LAMBO C A,et al.Lipid metabolism is altered in maternal,placental,and fetal tissues of ewes with small for gestational age fetuses[J].Biol Reprod,2021,104(1):170-180.
[18]	BELL A W,BAUMAN D E.Adaptations of glucose metabolism during pregnancy and lactation[J].J Mammary Gland Biol Neoplasia,1997,2(3):265-278.
[19]	何健闻.妊娠后期热应激的母体生理响应及肠道菌群作用与机制[D].南京:南京农业大学,2020.HE J W.A study on the function and mechanism of intestinal microbiota involved in the maternal physiological response to late gestational heat stress[D].Nanjing:Nanjing Agricultural University,2020.(in Chinese)
[20]	SANTAROSA B P,FERREIRA D O L,HOOPER H B,et al.Endocrine-metabolic adaptations in dorper ewes:comparison between single and twin pregnancies during gestation,parturition,and postpartum[J].Trop Anim Health Prod,2022,54(5):307.
[21]	VEJRAZKOVA D,VCELAK J,VANKOVA M,et al.Steroids and insulin resistance in pregnancy[J].J Steroid Biochem Mol Biol,2014,139:122-129.
[22]	BARRETT H L,NITERT M D,D’EMDEN M,et al.Capillary triglycerides in late pregnancy-challenging to measure,hard to interpret:a cohort study of practicality[J].Nutrients,2021,13(4):1266.
[23]	GRIFFITH R J,ALSWEILER J,MOORE A E,et al.Interventions to prevent women from developing gestational diabetes mellitus:an overview of cochrane reviews[J].Cochrane Database Syst Rev,2020,6(6):CD012394.
[24]	CUI Y Z,SHAN Z R,HOU L T,et al.Effect of natural Chinese herbal supplements (TCMF4) on lactation performance and serum biomarkers in peripartal dairy cows[J].Front Vet Sci,2022,8:801418.
[25]	ROCHE J R,FRIGGENS N C,KAY J K,et al.Invited review:body condition score and its association with dairy cow productivity,health,and welfare[J].J Dairy Sci,2009,92(12):5769-5801.
[26]	郭启勇.奶牛产后瘤胃液代谢组与血液生化指标、炎性因子变化规律研究[D].银川:宁夏大学,2020.GUO Q Y.Changes of rumen fluid metabolome,blood biochemical indexes and inflammatory factors in postpartum dairy cows[D].Yinchuan:Ningxia University,2020.(in Chinese)
[27]	SPAANS O K,KUHN-SHERLOCK B,HICKEY A,et al.Temporal profiles describing markers of inflammation and metabolism during the transition period of pasture-based,seasonal-calving dairy cows[J].J Dairy Sci,2022,105(3):2669-2698.
[28]	汪雅哲.围产期健康奶牛和脂肪肝奶牛血液代谢谱的比较分析[D].长春:吉林大学,2020.WANG Y Z.Comparison and evalation of blood metabolism profiles in peripartum healthy and fatty liver dairy cows[D].Changchun: Jilin University,2020.(in Chinese)
[29]	DENG F L,MCCLURE M,RORIE R,et al.The vaginal and fecal microbiomes are related to pregnancy status in beef heifers[J].J Anim Sci Biotechnol,2019,10(1):92.
[30]	张科.妊娠期-泌乳期山羊母体微生物垂直影响子代胃肠道菌群与肠道功能的研究[D].杨凌:西北农林科技大学,2022.ZHANG K.Vertical effects of maternal microbiota on the GIT microbiome and gut function of offspring during pregnancy and lactation period in female goats[D].Yangling:Northwest A&F University,2022.(in Chinese)
[31]	焦万洪,李莉.牛瘤胃内主要细菌结构与功能探查[J].中国畜禽种业,2016,12(2):84.JIAO W H,LI L.Investigation on the structure and function of main bacteria in the rumen of cattle[J].The Chinese Livestock and Poultry Breeding,2016,12(2):84.(in Chinese)
[32]	KOREN O,GOODRICH J K,CULLENDER T C,et al.Host remodeling of the gut microbiome and metabolic changes during pregnancy[J].Cell,2012,150(3):470-480.
[33]	MAO S Y,ZHANG M L,LIU J H,et al.Characterising the bacterial microbiota across the gastrointestinal tracts of dairy cattle:membership and potential function[J].Sci Rep,2015,5:16116.
[34]	JIA X B,HE Y,KANG Z,et al.Comparison of fecal microbiota communities between primiparous and multiparous cows during non-pregnancy and pregnancy[J].Animals,2023,13(5):869.
[35]	QUEREDA J J,BARBA M,MOCÉ M L,et al.Vaginal microbiota changes during estrous cycle in dairy heifers[J].Front Vet Sci, 2020, 7:371.
[36]	GENÍS S,CERRI R L A,BACH À,et al.Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle[J].Front Vet Sci,2018,5:135.
[37]	TARDÓN D C,HOFFMANN C,SANTOS F C R,et al.Relationships among indicators of metabolism,mammary health and the microbiomes of periparturient holstein cows[J].Animals,2022,12(1):3.
[38]	SHI Y,MIAO Z Y,SU J P,et al.Shift of maternal gut microbiota of tibetan antelope (Pantholops hodgsonii) during the periparturition period[J].Curr Microbiol,2021,78(2):727-738.
[39]	张卓,黄金秀,杨飞云,等.早期粪菌移植对仔猪肠道发育、肠道菌群组成和肠道激素分泌的影响[J].动物营养学报,2021, 33(7): 3745-3758.ZHANG Z,HUANG J X,YANG F Y,et al.Effects of early fecal microbiota transplantation on intestinal development,intestinal microbiota composition and intestinal hormone secretion of piglets[J].Chinese Journal of Animal Nutrition,2021,33(7):3745-3758.(in Chinese)
[40]	CHONG S C,SUKOR N,ROBERT S A,et al.Endogenous GLP-1 levels play an important role in determining the efficacy of DPP-IV Inhibitors in both prediabetes and type 2 diabetes[J].Front Endocrinol,2022,13:1012412.
[41]	ZHANG K,FUJITA Y,CHANG L J,et al.Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress[J].Transl Psychiatry,2019,9(1):231.
[42]	KELLY T N,BAZZANO L A,AJAMI N J,et al.Gut microbiome associates with lifetime cardiovascular disease risk profile among bogalusa heart study participants[J].Circ Res,2016,119(8):956-964.
[43]	KLEIN-JÖBSTL D,QUIJADA N M,DZIECIOL M,et al.Microbiota of newborn calves and their mothers reveals possible transfer routes for newborn calves’ gastrointestinal microbiota[J].PLoS One,2019,14(8):e0220554.
[44]	徐晓锋,郭成.淀粉诱导奶牛乳脂下降后奶牛瘤胃细菌菌群变化[J].浙江农业学报,2019,31(10):1591-1598.XU X F,GUO C.Changes of rumen bacterial flora after starch induced milk fat depression in dairy cows[J].Acta Agriculturae Zhejiangensis,2019,31(10):1591-1598.(in Chinese)
[45]	OTERC C,DE RUIZ C S,IBAÑEZ R,et al.Lactobacilli and enterococci isolated from the bovine vagina during the estrous cycle[J].Anaerobe,1999,5(3-4):305-307.
[46]	NURIEL-OHAYON M,NEUMAN H,ZIV O,et al.Progesterone increases Bifidobacterium relative abundance during late pregnancy[J]. Cell Rep,2019,27(3):730-736. e3.
[47]	HARDING J E,EVANS P C,GLUCKMAN P D.Maternal growth hormone treatment increases placental diffusion capacity but not fetal or placental growth in sheep[J].Endocrinology,1997,138(12):5352-5358.
[48]	赵晓娥,宋爱爱,孙念琴,等.配种时间对母羊妊娠期生殖激素与生长激素的影响[J].家畜生态学报,2018,39(2):75-78,93.ZHAO X E,SONG A A,SUN N Q,et al.Effect of mating time on reproductive hormone and growth hormone of preganant ewes[J].Acta Ecologae Animalis Domastici,2018,39(2):75-78,93.(in Chinese)
[49]	WALLACE J M,MILNE J S,AITKEN R P.Maternal growth hormone treatment from day 35 to 80 of gestation alters nutrient partitioning in favor of uteroplacental growth in the overnourished adolescent sheep1[J].Biol Reprod,2004,70(5):1277-1285.
[50]	RIBEIRO E S,BRUNO R G S,FARIAS A M,et al.Low doses of bovine somatotropin enhance conceptus development and fertility in lactating dairy cows[J].Biol Reprod,2014,90(1):10.
[51]	SFERRUZZI-PERRI A N,SANDOVICI I,CONSTANCIA M,et al.Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth[J].J Physiol,2017,595(15):5057-5093.
[52]	CARDOSO C L,SOMWE D,ESPOSITO G.0776 neonate immunity,growth,and puberty in dairy calves:influence of dietary conjugated linoleic acid supplementation of the dam[J].J Anim Sci,2016,94(S5):373.
[53]	MAZURKIEWICZ D,BRONKOWSKA M.Circulating insulin and IGF-1 and frequency of food consumption during pregnancy as predictors of birth weight and length[J].Nutrients,2021,13(7):2344.
[54]	STREMMING J,HEARD S,WHITE A,et al.IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus[J].Am J Physiol Endocrinol Metab,2021,320(3):E527-E538.
[55]	CHEN Z L,MEIMA M E,PEETERS R P,et al.Thyroid hormone transporters in pregnancy and fetal development[J].Int J Mol Sci,2022,23(23):15113.
[56]	CARVALHO D P,DIAS A F,SFERRUZZI-PERRI A N,et al.Gaps in the knowledge of thyroid hormones and placental biology[J]. Biol Reprod,2022,106(6):1033-1048.
[57]	FORHEAD A J,FOWDEN A L.Thyroid hormones in fetal growth and prepartum maturation[J].J Endocrinol,2014,221(3):R87-R103.
[58]	钟俊洁,杨桂芳,刘帅,等.甲状腺激素受体α在猪有腔卵泡发育和孤雌激活胚胎发育过程中表达模式[J].畜牧兽医学报, 2014,45(6):901-909.ZHONG J J,YANG G F,LIU S,et al.Expression pattern analysis of thyroid hormone receptor alpha in pig antral follicles and parthenogenetic early embryos[J].Acta Veterinaria et Zootechnica Sinica,2014,45(6):901-909.(in Chinese)
[59]	DAVIES K L,CAMM E J,ATKINSON E V,et al.Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth[J].J Physiol,2020,598(12):2453-2468.
[60]	EERDEKENS A,VERHAEGHE J,DARRAS V,et al.The placenta in fetal thyroid hormone delivery:from normal physiology to adaptive mechanisms in complicated pregnancies[J].J Matern Fetal Neonatal Med,2020,33(22):3857-3866.
[61]	CHENG P K,CHEN H C,KUO P L,et al.Associations between oxidative/nitrosative stress and thyroid hormones in pregnant women-Tainan birth cohort study (TBCS)[J].Antioxidants (Basel),2022,11(2):334.
[62]	VONNAHME K A,NEVILLE T L,PERRY G A,et al.Maternal dietary intake alters organ mass and endocrine and metabolic profiles in pregnant ewe lambs[J].Anim Reprod Sci,2013,141(3-4):131-141.
[63]	姚路连.奶牛围产期血清相关激素水平动态变化的研究[D].扬州:扬州大学,2014.YAO L L.Study on dynamic changes of serum hormone indexes in perinatal dairy cows[D].Yangzhou:Yangzhou University,2014.(in Chinese)
[64]	CAMACHO L E,MEYER A M,NEVILLE T L,et al.Neonatal hormone changes and growth in lambs born to dams receiving differing nutritional intakes and selenium supplementation during gestation[J].Reproduction,2012,144(1):23-35.
[65]	LEMLEY C O,MEYER A M,NEVILLE T L,et al.Dietary selenium and nutritional plane alter specific aspects of maternal endocrine status during pregnancy and lactation[J].Domest Anim Endocrinol,2014,46:1-11.
[66]	SARMIENTO-ORTEGA V E,MORONI-GONZÁLEZ D,DIAZ A,et al.Hepatic insulin resistance model in the male wistar rat using exogenous insulin glargine administration[J].Metabolites,2023,13(4):572.
[67]	BRIT H B,LAURA D B,STEPHANIE R W,et al.A chronic fetal leucine infusion potentiates fetal insulin secretion and increases pancreatic islet size,vascularity,and β cells in late-gestation sheep[J].J Nutr,2020,150(8):2061-2069.
[68]	VAUGHAN O R,ROSARIO F J,POWELL T L,et al.Regulation of placental amino acid transport and fetal growth[J].Prog Mol Biol Transl Sci,2017,145:217-251.
[69]	HAY W W Jr.Recent observations on the regulation of fetal metabolism by glucose[J].J Physiol,2006,572(1):17-24.
[70]	JOVANDARIC M Z,MILENKOVIC S J,BABOVIC I R,et al.The effect of glucose metabolism and breastfeeding on the intestinal microbiota of newborns of women with gestational diabetes mellitus[J].Medicina (Kaunas),2022,58(3):413.
[71]	BI Y L,TU Y,ZHANG N F,et al.Multiomics analysis reveals the presence of a microbiome in the gut of fetal lambs[J]. Gut, 2021,70(5):853-864.
[72]	ALIPOUR M J,JALANKA J,PESSA-MORIKAWA T,et al.The composition of the perinatal intestinal microbiota in cattle[J].Sci Rep,2018,8(1):10437.
[73]	UHLIG H H,POWRIE F.Dendritic cells and the intestinal bacterial flora:a role for localized mucosal immune responses[J].J Clin Invest,2003,112(5):648-651.
[74]	RESCIGNO M,URBANO M,VALZASINA B,et al.Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria[J].Nat Immunol,2001,2(4):361-367.
[75]	郭伟.放牧牦牛瘤胃微生物发育模式研究[D].兰州:兰州大学,2021.GUO W.The development model of microbiota in the rumen of grazing yaks[D].Lanzhou:Lanzhou University,2021.(in Chinese)
[76]	BI Y L,COX M S,ZHANG F,et al.Feeding modes shape the acquisition and structure of the initial gut microbiota in newborn lambs[J].Environ Microbiol,2019,21(7):2333-2346.
[77]	ZHANG J B,LIANG Z Y,KAO R D,et al.Maternal fecal microbes contribute to shaping the early life assembly of the intestinal microbiota of co-inhabiting yak and cattle calves[J].Front Microbiol,2022,13:916735.
[78]	GUO J Z,LI P F,ZHANG K,et al.Distinct stage changes in early-life colonization and acquisition of the gut microbiota and its correlations with volatile fatty acids in goat kids[J].Front Microbiol,2020,11:584742.
[79]	SANTILLO A,FIGLIOLA L,CILIBERTI M G,et al.Focusing on fatty acid profile in milk from different species after in vitro digestion[J].J Dairy Res,2018,85(2):257-262.
[80]	STINSON L F,GAY M C L,KOLEVA P T,et al.Human milk from atopic mothers has lower levels of short chain fatty acids[J]. Front Immunol,2020,11:1427.
[81]	CHOW J,PANASEVICH M R,ALEXANDER D,et al.Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation[J].J Proteome Res,2014,13(5):2534-2542.
[82]	JIANG T M,LIU B,LI J F,et al.Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome[J].Food Funct,2018,9(2):1028-1037.
[83]	LI Y P,REN L,WANG Y Y,et al.The effect of breast milk microbiota on the composition of infant gut microbiota:a cohort study[J].Nutrients,2022,14(24):5397.
[84]	GENSOLLEN T,IYER S S,KASPER D L,et al.How colonization by microbiota in early life shapes the immune system[J]. Science, 2016,352(6285):539-544.
[85]	MISHRA A,LAI G C,YAO L J,et al.Microbial exposure during early human development primes fetal immune cells[J].Cell, 2021,184(13):3394-3409. e20.
[86]	YU K,RODRIGUEZ M D,PAUL Z,et al.Proof of principle:physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep[J].PLoS One,2019,14(6):e0217211.
[87]	DE AGVERO M G,GANAL-VONARBURG S C,FUHRER T,et al.The maternal microbiota drives early postnatal innate immune development[J].Science,2016,351(6279):1296-1302.
[88]	KAO H F,WANG Y C,TSENG H Y,et al.Goat milk consumption enhances innate and adaptive immunities and alleviates allergen-induced airway inflammation in offspring mice[J].Front Immunol,2020,11:184.
[89]	WANG K,HU C J,TANG W,et al.The enhancement of intestinal immunity in offspring piglets by maternal probiotic or synbiotic supplementation is associated with the alteration of gut microbiota[J].Front Nutr,2021,8:686053.

Research Progress on Physiological Metabolism and Microbial Changes of Ruminants During Gestation and Lactation and Their Effects on Offspring Development

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[13]	LI Zhenming, YU Miao, TANG Yantian, LI Yuanfei, LIU Zhichang, RONG Ting, MA Xianyong. Effects of Sodium Humate on Nutrient Apparent Digestibility, Fecal Microorganisms and Their Metabolites in White-feathered Broilers [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5091-5100.
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