Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (5): 1792-1803.doi: 10.11843/j.issn.0366-6964.2023.05.003
• REVIEW • Previous Articles Next Articles
ZHAO Wei1,2, Mahmoud M. Abdelsattar1, CHAI Jianmin1,3, WANG Xin2, DIAO Qiyu1, ZHANG Naifeng1*
Received:
2022-11-04
Online:
2023-05-23
Published:
2023-05-20
CLC Number:
ZHAO Wei, Mahmoud M. Abdelsattar, CHAI Jianmin, WANG Xin, DIAO Qiyu, ZHANG Naifeng. Research Progress of Rumen Microbiota Transplantation and Its Application[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1792-1803.
[1] | WEIMER P J.Redundancy,resilience,and host specificity of the ruminal microbiota:Implications for engineering improved ruminal fermentations[J]. Front Microbiol,2015,6:296. |
[2] | NA S W,GUAN L L.Understanding the role of rumen epithelial host-microbe interactions in cattle feed efficiency[J]. Anim Nutr,2022,10:41-53. |
[3] | HUWS S A,CREEVEY C J,OYAMA L B,et al.Addressing global ruminant agricultural challenges through understanding the rumen microbiome:Past,present,and future[J]. Front Microbiol,2018,9:2161. |
[4] | HU F,XUE Y F,GUO C Z,et al.The response of ruminal fermentation,epithelium-associated microbiota,and epithelial barrier function to severe feed restriction in pregnant ewes[J]. J Anim Sci,2018,96(10):4293-4305. |
[5] | MYER P R,FREETLY H C,WELLS J E,et al.Analysis of the gut bacterial communities in beef cattle and their association with feed intake,growth,and efficiency[J]. J Anim Sci,2017,95(7):3215-3224. |
[6] | SHABAT S K B,SASSON G,DORON-FAIGENBOIM A,et al.Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants[J]. ISME J,2016,10(12):2958-2972. |
[7] | MAO S Y,HUO W J,ZHU W Y.Microbiome-metabolome analysis reveals unhealthy alterations in the composition and metabolism of ruminal microbiota with increasing dietary grain in a goat model[J]. Environ Microbiol,2016,18(2):525-541. |
[8] | MORGAVI D P,RATHAHAO-PARIS E,POPOVA M,et al.Rumen microbial communities influence metabolic phenotypes in lambs[J]. Front Microbiol,2015,6:1060. |
[9] | KHAFIPOUR E,LI S C,PLAIZIER J C,et al.Rumen microbiome composition determined using two nutritional models of subacute ruminal acidosis[J]. Appl Environ Microbiol,2009,75(22):7115-7124. |
[10] | SHI W B,MOON C D,LEAHY S C,et al.Methane yield phenotypes linked to differential gene expression in the sheep rumen microbiome[J]. Genome Res,2014,24(9):1517-1525. |
[11] | MCALLISTER T A,BEAUCHEMIN K A,ALAZZEH A Y,et al.Review:The use of direct fed microbials to mitigate pathogens and enhance production in cattle[J]. Can J Anim Sci,2011,91(2):193-211. |
[12] | DEPETERS E J,GEORGE L W.Rumen transfaunation[J]. Immunol Lett,2014,162(2):69-76. |
[13] | DE GROOT P F,FRISSEN M N,DE CLERCQ N C,et al.Fecal microbiota transplantation in metabolic syndrome:History, present and future[J]. Gut Microbes,2017,8(3):253-267. |
[14] | BRAG S,HANSEN H J.Treatment of ruminal indigestion according to popular belief in Sweden[J]. Rev Sci Tech,1994, 13(2):529-535. |
[15] | SINGH R,LANGAR P N,BHATIA I S.Effect of the exchange of rumen contents in the buffalo and zebu on the number of Oscillospira guillermondii[J]. Indian J Vet Sci Anim Husb,1968,38:689-692. |
[16] | WAYMACK L B.Effect of feeding lyophilized rumen contents on adaptation to urea diet by lambs[J]. J Anim Sci,1976, 43(3):712-714. |
[17] | ZHONG R Z,SUN H X,LI G D,et al.Effects of inoculation with rumen fluid on nutrient digestibility,growth performance and rumen fermentation of early weaned lambs[J]. Livest Sci,2014,162:154-158. |
[18] | ABO-DONIA F M,GHADA S I,NADI S,et al.Effect of inoculating new born lambs with fresh or lyophilized rumen fluid on rumen activity and lamb performance[J]. J Am Sci,2011,7(9):409-422. |
[19] | YU S B,SHI W B,YANG B,et al.Effects of repeated oral inoculation of artificially fed lambs with lyophilized rumen fluid on growth performance,rumen fermentation,microbial population and organ development[J]. Anim Feed Sci Technol,2020,264:114465. |
[20] | PALMA-HIDALGO J M,JIMENEZ E,POPOVA M,et al.Inoculation with rumen fluid in early life accelerates the rumen microbial development and favours the weaning process in goats[J]. Anim Microbiome,2021,3(1):11. |
[21] | HUANG S,ZHENG G,MEN H K,et al.The response of fecal microbiota and host metabolome in dairy cows following rumen fluid transplantation[J]. Front Microbiol,2022,13:940158. |
[22] | MUSCATO T V,TEDESCHI L O,RUSSELL J B.The effect of ruminal fluid preparations on the growth and health of newborn,milk-fed dairy calves[J]. J Dairy Sci,2002,85(3):648-656. |
[23] | PARK T,CERSOSIMO L M,LI W L,et al.Pre-weaning ruminal administration of differentially-enriched,rumen-derived inocula shaped rumen bacterial communities and co-occurrence networks of post-weaned dairy calves[J]. Front Microbiol,2021, 12:625488. |
[24] | CERSOSIMO L M,RADLOFF W,ZANTON G I.Microbial inoculum composition and pre-weaned dairy calf age alter the developing rumen microbial environment[J]. Front Microbiol,2019,10:1651. |
[25] | PARK T,CERSOSIMO L M,RADLOFF W,et al.The rumen liquid metatranscriptome of post-weaned dairy calves differed by pre-weaning ruminal administration of differentially-enriched,rumen-derived inocula[J]. Anim Microbiome,2022,4(1):4. |
[26] | LIU K Z,ZHANG Y D,YU Z T,et al.Ruminal microbiota-host interaction and its effect on nutrient metabolism[J]. Anim Nutr,2021,7(1):49-55. |
[27] | CHEN X D,YAN F,LIU T,et al.Ruminal microbiota determines the high-fiber utilization of ruminants:Evidence from the ruminal microbiota transplant[J]. Microbiol Spectr,2022,10(4):e00446-22. |
[28] | CHEN X D,SU X D,LI J L,et al.Real-time monitoring of ruminal microbiota reveals their roles in dairy goats during subacute ruminal acidosis[J]. npj Biofilms Microbiomes,2021,7(1):45. |
[29] | ZHOU M,PENG Y J,CHEN Y H,et al.Assessment of microbiome changes after rumen transfaunation:implications on improving feed efficiency in beef cattle[J]. Microbiome,2018,6(1):62. |
[30] | IMAI S,MATSUMOTO M,WATANABE A,et al.Establishment of a spinated type of Diplodinium rangiferi by transfaunation of the rumen ciliates of Japanese sika deer (Cervus nippon centralist to the Rumen of Two Japanese Shorthorn Calves (Bos taurus taurus)[J]. J Eukaryot Microbiol,2002,49(1):38-41. |
[31] | WILLIAMS A G,WITHERS S E.Changes in the rumen microbial population and its activities during the refaunation period after the reintroduction of ciliate protozoa into the rumen of defaunated sheep[J]. Can J Microbiol,1993,39(1):61-69. |
[32] | SANTOS B P,BESSEGATTO J A,ALFIERI A A,et al.Transfaunation of the ruminal fluid from cows alters ruminal microbiota structure but not dominant protozoa in healthy sheep[J]. Small Ruminant Res,2021,194:106283. |
[33] | STEINER S,LINHART N,NEIDL A,et al.Evaluation of the therapeutic efficacy of rumen transfaunation[J]. J Anim Physiol Anim Nutr,2020,104(1):56-63. |
[34] | JASMIN B H,BOSTON R C,MODESTO R B,et al.Perioperative ruminal pH changes in domestic sheep (Ovis aries) housed in a biomedical research setting[J]. J Am Assoc Lab Anim Sci,2011,50(1):27-32. |
[35] | CONRAD H R,HIBBS J W,POUNDEN W D,et al.The effect of rumen inoculations on the digestibility of roughages in young dairy calves[J]. J Dairy Sci,1950,33(8):585-592. |
[36] | RICO D E,YING Y,CLARKE A R,et al.The effect of rumen digesta inoculation on the time course of recovery from classical diet-induced milk fat depression in dairy cows[J]. J Dairy Sci,2014,97(6):3752-3760. |
[37] | WEIMER P J,COX M S,DE PAULA T V,et al.Transient changes in milk production efficiency and bacterial community composition resulting from near-total exchange of ruminal contents between high-and low-efficiency Holstein cows[J]. J Dairy Sci,2017,100(9):7165-7182. |
[38] | ARIK H D,GULSEN N,HAYIRLI A,et al.Efficacy of Megasphaera elsdenii inoculation in subacute ruminal acidosis in cattle[J]. J Anim Physiol Anim Nutr (Berl),2019,103(2):416-426. |
[39] | QUIRK M F,BUSHELL J J,JONES R J,et al.Live-weight gains on leucaena and native grass pastures after dosing cattle with rumen bacteria capable of degrading DHP,a ruminal metabolite from leucaena[J]. J Agric Sci,1988,111(1):165-170. |
[40] | DA SILVA L C A,PESSOA D A D N,LOPES J R G,et al.Resistance transferance of Amorimia septentrionalis poisoning in goats by ruminal transferance fluid from goats with induced resistance by the inoculation of sodium monofluoroacetate-degrading bacteria[J]. Ciencia Rural,2015,45(12):2218-2222. |
[41] | RAGER K D,GEORGE L W,HOUSE J K,et al.Evaluation of rumen transfaunation after surgical correction of left-sided displacement of the abomasum in cows[J]. J Am Vet Med Assoc,2004,225(6):915-920. |
[42] | LIU J H,LI H W,ZHU W Y,et al.Dynamic changes in rumen fermentation and bacterial community following rumen fluid transplantation in a sheep model of rumen acidosis:implications for rumen health in ruminants[J]. FASEB J,2019,33(7):8453-8467. |
[43] | JI S K,JIANG T,YAN H,et al.Ecological restoration of antibiotic-disturbed gastrointestinal microbiota in foregut and hindgut of cows[J]. Front Cell Infect Microbiol,2018,8:79. |
[44] | LEO-PENU C L O,FITZPATRICK L A,ZERBY H N,et al.Treating Bos indicus bulls with rumen transfaunation after 24 hours of transportation does not replete muscle glycogen[J]. Anim Prod Sci,2015,10(56):1738-1744. |
[45] | VAN METRE D C,CALLAN R J,HOLT T N,et al.Abdominal emergencies in cattle[J]. Vet Clin North Am Food Anim Pract, 2005, 21(3):655-696. |
[46] | BU D P,ZHANG X,MA L,et al.Repeated inoculation of young calves with rumen microbiota does not significantly modulate the rumen prokaryotic microbiota consistently but decreases diarrhea[J]. Front Microbiol,2020,11:1403. |
[47] | 张鑫.灌服瘤胃液对犊牛生长性能及胃肠道发育的影响[D].扬州:扬州大学,2017.ZHANG X.Effects of rumen fluid on growth performance and gastrointestinal development of calves[D].Yangzhou:Yangzhou University,2017.(in Chinese) |
[48] | YÁÑEZ-RUIZ D R,ABECIA L,NEWBOLD C J.Manipulating rumen microbiome and fermentation through interventions during early life:a review[J]. Front Microbiol,2015,6:1133. |
[49] | YIN X,JI S,DUAN C,et al.Rumen fluid transplantation affects growth performance of weaned lambs by altering gastrointestinal microbiota,immune function and feed digestibility[J]. Animal,2021,15(1):100076. |
[50] | MU Y Y,QI W P,ZHANG T,et al.Changes in rumen fermentation and bacterial community in lactating dairy cows with subacute rumen acidosis following rumen content transplantation[J]. J Dairy Sci,2021,104(10):10780-10795. |
[51] | CERSOSIMO L M,RADLOFF W,ZANTON G I.Microbial inoculum composition and pre-weaned dairy calf age alter the developing rumen microbial environment[J]. Front Microbiol,2019,10:1651. |
[52] | PEÑA-CEARRA A,BELANCHE A,GONZALEZ-LOPEZ M,et al.Peripheral blood mononuclear cells (PBMC) microbiome is not affected by colon microbiota in healthy goats[J]. Anim Microbiome,2021,3(1):28. |
[53] | HITCH T C A,HALL L J,WALSH S K,et al.Microbiome-based interventions to modulate gut ecology and the immune system[J]. Mucosal Immunol,2022,15(6):1095-1113. |
[54] | HAN L L,XUE W C,CAO H W,et al.Comparison of rumen fermentation parameters and microbiota of yaks from different altitude regions in Tibet,China[J]. Front Microbiol,2022,12:807512. |
[55] | DE BARBIERI I,HEGARTY R S,SILVEIRA C,et al.Programming rumen bacterial communities in newborn Merino lambs[J]. Small Ruminant Res,2015,129:48-59. |
[56] | FRIEDMAN N,JAMI E,MIZRAHI I.Compositional and functional dynamics of the bovine rumen methanogenic community across different developmental stages[J]. Environ Microbiol,2017,19(8):3365-3373. |
[57] | BELANCHE A,PALMA-HIDALGO J M,NEJJAM I,et al. In vitro assessment of the factors that determine the activity of the rumen microbiota for further applications as inoculum[J]. J Sci Food Agric,2019,99(1):163-172. |
[58] | SHEN J S,CHAI Z,SONG L J,et al.Insertion depth of oral stomach tubes may affect the fermentation parameters of ruminal fluid collected in dairy cows[J]. J Dairy Sci,2012,95(10):5978-5984. |
[59] | LI M,PENNER G B,HERNANDEZ-SANABRIA E,et al.Effects of sampling location and time,and host animal on assessment of bacterial diversity and fermentation parameters in the bovine rumen[J]. J Appl Microbiol,2009,107(6):1924-1934. |
[60] | WEIMER P J.Redundancy,resilience,and host specificity of the ruminal microbiota:implications for engineering improved ruminal fermentations[J]. Front Microbiol,2015,6:296. |
[61] | MALMUTHUGE N,GUAN L L.Understanding host-microbial interactions in rumen:searching the best opportunity for microbiota manipulation[J]. J Anim Sci Biotechnol,2017,8:8. |
[62] | RIBEIRO G O,OSS D B,HE Z X,et al.Repeated inoculation of cattle rumen with bison rumen contents alters the rumen microbiome and improves nitrogen digestibility in cattle[J]. Sci Rep,2017,7(1):1276. |
[63] | HUANG W Q,CUI K,HAN Y,et al.Long term effects of artificial rearing before weaning on the growth performance, ruminal microbiota and fermentation of fattening lambs[J]. J Integr Agr,2022,21(4):1146-1160. |
[64] | CHAI J M,DIAO Q Y,WANG H C,et al.Effects of weaning age on growth,nutrient digestibility and metabolism,and serum parameters in Hu lambs[J]. Anim Nutr,2015,1(4):344-348. |
[65] | BHARANIDHARAN R,LEE C H,THIRUGNANASAMBANTHAM K,et al.Feeding systems and host breeds influence ruminal fermentation,methane production,microbial diversity and metagenomic gene abundance[J]. Front Microbiol,2021, 12:701081. |
[66] | SPANGHERO M,CHIARAVALLI M,COLOMBINI S,et al.Rumen inoculum collected from cows at slaughter or from a continuous fermenter and preserved in warm,refrigerated,chilled or freeze-dried environments for in vitro tests[J]. Animals, 2019,9(10):815. |
[67] | MOULD F L,KLIEM K E,MORGAN R,et al. In vitro microbial inoculum:a review of its function and properties[J]. Anim Feed Sci Technol,2005,123-124:31-50. |
[68] | COX M S,DEBLOIS C L,SUEN G.Assessing the response of ruminal bacterial and fungal microbiota to whole-rumen contents exchange in dairy cows[J]. Front Microbiol,2021,12:665776. |
[69] | COLE N A.Effects of animal-to-animal exchange of ruminal contents on the feed intake and ruminal characteristics of fed and fasted lambs[J]. J Anim Sci,1991,69(4):1795-1803. |
[70] | BELANCHE A,PALMA-HIDALGO J M,NEJJAM I,et al.Inoculation with rumen fluid in early life as a strategy to optimize the weaning process in intensive dairy goat systems[J]. J Dairy Sci,2020,103(6):5047-5060. |
[71] | YU S B,ZHANG G Y,LIU Z B,et al.Repeated inoculation with fresh rumen fluid before or during weaning modulates the microbiota composition and co-occurrence of the rumen and colon of lambs[J]. BMC Microbiol,2020,20(1):29. |
[72] | 王佳堃,杨斌,黄开朗.幼龄反刍动物消化道微生物演替与消化道发育及其调控[J].动物营养学报,2020, 32(10):4697-4707.WANG J K,YANG B,HUANG K L.Regulation of microbial succession and gastrointestinal development in young ruminants[J]. Chinese Journal of Animal Nutrition,2020,32(10):4697-4707.(in Chinese) |
[73] | ABDELSATTAR M M,VARGAS-BELLO-PÉREZ E,ZHUANG Y M,et al.Impact of dietary supplementation of β-hydroxybutyric acid on performance,nutrient digestibility,organ development and serum stress indicators in early-weaned goat kids[J]. Anim Nutr,2022,9:16-22. |
[74] | GÓRKA P,KOWALSKI Z M,ZABIELSKI R,et al. Invited review:use of butyrate to promote gastrointestinal tract development in calves[J]. J Dairy Sci,2018,101(6):4785-4800. |
[75] | LIANG G X,MALMUTHUGE N,MCFADDEN T B,et al.Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life[J]. PLoS One,2014,9(3):e92592. |
[76] | WON M Y,OYAMA L B,COURTNEY S J,et al.Can rumen bacteria communicate to each other[J]. Microbiome, 2020,8(1):23. |
[77] | 张定然,吴燕,邢小光,等.瘤胃液移植技术及应用的研究进展[J].中国畜牧杂志,2021,57(8):28-32.ZHANG D R,WU Y,XING X G,et al.Research progress on the technology and application of rumen fluid transplantion[J]. Chinese Journal of Animal Science,2021,57(8):28-32.(in Chinese) |
[78] | DEFILIPP Z,BLOOM P P,SOTO M T,et al.Drug-Resistant E. coli bacteremia transmitted by fecal microbiota transplant[J]. N Engl J Med,2019,381(21):2043-2050. |
[79] | 焦帅,付域泽,张乃锋.下一代益生菌作用机制及功能特性研究进展[J].动物营养学报,2022,34(8):4836-4846.JIAO S,FU Y Z,ZHANG N F.Progress on mechanism and functional characteristics of next generation probiotics[J]. Chinese Journal of Animal Nutrition,2022,34(8):4836-4846.(in Chinese) |
[80] | HU J,CHEN L L,TANG Y M,et al.Standardized preparation for fecal microbiota transplantation in pigs[J]. Front Microbiol, 2018,9:1328. |
[81] | QAZI T,AMARATUNGA T,BARNES E L,et al.The risk of inflammatory bowel disease flares after fecal microbiota transplantation:systematic review and meta-analysis[J]. Gut Microbes,2017,8(6):574-588. |
[82] | FANIYI T O,ADEGBEYE M J,ELGHANDOUR M M M Y,et al.Role of diverse fermentative factors towards microbial community shift in ruminants[J]. J Appl Microbiol,2019,127(1):2-11. |
[83] | WEIMER P J,STEVENSON D M,MANTOVANI H C,et al.Host specificity of the ruminal bacterial community in the dairy cow following near-total exchange of ruminal contents[J]. J Dairy Sci,2010,93(12):5902-5912. |
[84] | NAVARRE C B,BAIRD A N,PUGH D G.Diseases of the gastrointestinal system[M]//PUGH D G,BAIRD A N.Sheep and Goat Medicine.2nd ed.Amsterdam:Elsevier,2012:71-105. |
[85] | ASRAT M,MANOHAR B M,MELKAMU S.Clinical and rumen fluid evaluation of ruminal disorders in cattle[J]. J Anim Res, 2015,5(2):359-372. |
[86] | KRAUSE K M,OETZEL G R.Understanding and preventing subacute ruminal acidosis in dairy herds:a review[J]. Anim Feed Sci Technol,2006,126(3-4):215-236. |
[87] | ZHANG T,LU G C,ZHAO Z,et al.Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening[J]. Protein Cell,2020,11(4):251-266. |
[88] | ZHAO W,ABDELSATTAR M M,WANG X,et al. In vitro modulation of rumen fermentation by microbiota from the recombination of rumen fluid and solid phases[J]. Microbiol Spectr,2023,11(1):e03387-22. |
[89] | CHAI J M,LV X K,DIAO Q Y,et al.Solid diet manipulates rumen epithelial microbiota and its interactions with host transcriptomic in young ruminants[J]. Environ Microbiol,2021,23(11):6557-6568. |
[90] | 马涛,张乃锋,屠焰,等.羔羊瘤胃微生物区系建立、发展与调控技术研究进展[J].动物营养学报,2020, 32(10):4733-4742.MA T,ZHANG N F,TU Y,et al.Research advance in establishment,development and regulation technology of rumen microbiota in lambs[J]. Chinese Journal of Animal Nutrition,2020,32(10):4733-4742.(in Chinese) |
[91] | WALTER J,ARMET A M,FINLAY B B,et al.Establishing or exaggerating causality for the gut microbiome:lessons from human microbiota-associated rodents[J]. Cell,2020,180(2):221-232. |
[92] | WALTER J,MALDONADO-GÓMEZ M X,MARTÍNEZ I.To engraft or not to engraft:an ecological framework for gut microbiome modulation with live microbes[J]. Curr Opin Biotechnol,2018,49:129-139. |
[93] | LAVELLE A,SOKOL H.Understanding and predicting the efficacy of FMT[J]. Nat Med,2022,28(9):1759-1760. |
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[15] | WANG Yan-xin, XIE Shu-yu, CHEN Dong-mei, WANG Yu-lian, PAN Yuan-hu, PENG Da-peng, TAO Yan-fei, YUAN Zong-hui. Progress in the Application of Electrochemical Immunosensor in Food Safety Detection [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(7): 1334-1342. |
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