牦牛胸腺增龄性变化的形态学观察

doi:10.11843/j.issn.0366-6964.2013.08.019

Abstract

Abstract:

This experiment was conducted to study thymuses physiological and immunological functions. The age-associated changes in histology of the healthy yak's thymus at three different age groups (one-day-old, five-month-old and adult) were observed by histology, immunochemistry and statistics methods. The results showed that as the age increased, identifiable corticomedullary delineation became unclear; thymocytes in both the cortical and the medulla became sparse. These changes were accompanied by a marked increase in the content of interlobular connective and adipose tissue and thickening of the thymic capsule. S100 positive thymic dendritic cells (TDCs) were localized in the corticomedullary junction and medullary zones in each group. The average number of S100 positive thymic dendritic cells decreased per area while the age increased. And differences between each age group were significant (P<0.01). Moreover, the average number of Caspase-3 positive thymocytes per area increased while the age increased. Particularly, the average number of this cell in the cortex increased and there were significant differences between each age group (P<0.01). No difference (P>0.05) were observed between 5-month-old and adult group, but these two groups were significantly higher (P<0.01) than the 1-day-old group, respectively. The results indicated that the yak’s thymus showed obvious degeneration trend in structure and function which is possibly associated with the decrease of TDCs and increase of cortical apoptotic thymocytes. The underlying mechanism need to be investigated further.

CLC Number:

S852.16

ZHANG Qian, YU Si-jiu, HE Jun-feng, CUI Yan. Morphologycal Observation of Age-Associated Changes in the Thymus of the Yak[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(8): 1305-1310.

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Morphologycal Observation of Age-Associated Changes in the Thymus of the Yak

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