肠道共生生物对肠道干细胞的调节机制研究进展

doi:10.11843/j.issn.0366-6964.2025.03.005

Abstract

Abstract:

Intestinal stem cells (ISCs) are vital for maintaining intestinal homeostasis. Research indicates that intestinal commensal organisms, including microorganisms and parasites, along with their metabolites, play a crucial role in regulating host stem cells. These organisms can influence the renewal and differentiation of ISCs through direct or indirect mechanisms. This article delves into the impact of intestinal microbiota, worms, and their metabolites on ISCs, and provides an overview of current research on how related bacteria and metabolites affect the proliferation and differentiation of ISCs. The goal of this review is to offer innovative insights for potential future treatments of intestinal injuries.

Key words: gut microbiota, intestinal helminth, intestinal stem cell

CLC Number:

S852.2

DING Yingying, ZHANG Jiayun, TANG Longxuan, ZHANG Shaohua, GUO Xiaola, PU Lixia, MOU Wenjie, WANG Shuai. Research Progress on the Regulatory Mechanisms of Intestinal Commensal Organisms on Intestinal Stem Cells[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(3): 1019-1026.

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Research Progress on the Regulatory Mechanisms of Intestinal Commensal Organisms on Intestinal Stem Cells

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