哺乳动物线粒体动力学和氧化磷酸化研究进展

doi:10.11843/j.issn.0366-6964.2021.02.001

Abstract

Abstract: Mitochondria is an organelle with double layered membrane and fluidity, which is the main place for aerobic respiration of cells and provides energy for cell proliferation, migration and survival, hence it is called “power house”. Mitochondria plays an important role in biological processes such as cell death, cell senescence, autophagy, lipid synthesis, calcium homeostasis and iron balance, etc, and its function is mainly regulated by mitochondrial fusion and fission. ATP production is regulated by mitochondrial fusion related proteins such as mitofusin-1 (Mfn1), mitofusin-2 (Mfn2) and optic atrophy 1 (OPA1). Cell division and mitosis are promoted by mitochondria fission related proteins such as dynamin-related protein 1 (Drp1), fission 1 (Fis1), mitochondria fission factor (MFF) and mitochondria dynamin protein 49/51 (Mid49/51). This review discusses the molecular mechanisms of mitochondrial fusion, fission and oxidative phosphorylation, emphasizes the biological significance of mitochondrial morphology and dynamics, especially the regulation mechanism of mitochondria related genes and proteins in bodys and cells of animals, and prospects the research trends of mitochondrial dynamics and morphology in animal husbandry, which will provides a reference for mitochondrial research.

Key words: mitochondria, fusion, fission, oxidative phosphorylation

CLC Number:

Q244
S852.2

WEN Yuliang, LIU Xiu, WANG Jiqing, HU Jiang, LUO Yuzhu, LI Shaobin. Research Progress of Mitochondrial Dynamics and Oxidative Phosphorylation in Mammal[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(2): 273-285.

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Research Progress of Mitochondrial Dynamics and Oxidative Phosphorylation in Mammal

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