褪黑素的抗氧化机制及其在哺乳动物精子冷冻保存中的应用研究进展

doi:10.11843/j.issn.0366-6964.2023.11.004

Abstract

Abstract: Melatonin is an endogenous indole amine synthesized and secreted principally by the pineal gland in mammals. Distinct roles of 5-methoxy and N-acetyl groups determined the melatonin’s specificity and water-lipid solubility. In recent years, melatonin and its metabolites were proved to have an antioxidant, anti-inflammatory, anti-apoptotic and other biological activities, playing important roles in the complex physiological regulation of mammals. In this paper, we reviewed the research progress on biosynthesis and metabolism, antioxidant mechanisms of melatonin and its bio-effects on sperm cryopreservation, which will provide scientific basis for further research on the application of melatonin in in vitro preservation of animal cells.

Key words: melatonin, oxidative stress, mitochondria, sperm cryopreservation

CLC Number:

Q952
S813.3

LI Chunyan, ZHANG Yan, Lü Chunrong, DENG Weidong, QUAN Guobo. Research Progress on Antioxidant Mechanisms of Melatonin and Its Application in Cryopreservation of Mammalian Spermatozoa[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4468-4476.

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Research Progress on Antioxidant Mechanisms of Melatonin and Its Application in Cryopreservation of Mammalian Spermatozoa

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