五味子醇甲对鸡大肠杆菌病的预防效果观察

doi:10.11843/j.issn.0366-6964.2024.10.043

Abstract

Abstract:

To investigate the preventive effect of schisandrin A against chicken colibacillosis, 180 one-day-old chicks were divided into the following groups: control group, Escherichia coli infection group, 50 mg·kg^-1 schisandrin A group, 100 mg·kg^-1 schisandrin A group, 200 mg·kg^-1 schisandrin A group, and antibiotic group (florfenicol). After 5 days of administration, except for the control group, all other groups were intraperitoneally inoculated with E. coli suspension. The chicks' body weight, immune organ index, spleen histopathological and ultrastructural changes, blood cell count, serum inflammatory factors, antibody levels, and immunoglobulin changes were evaluated. The results demonstrated that pre-feeding schisandrin A improved the body weight of infected chicks, significantly reduced the spleen index, alleviated spleen tissue damage and cellular nuclear and mitochondrial injuries caused by E. coli infection. Furthermore, 200 mg·kg^-1 schisandrin A significantly reduced the white blood cell count in infected chickens, while both 100 mg·kg^-1 and 200 mg·kg^-1 schisandrin A groups significantly decreased the levels of TNF-α, IL-1β, IL-6, and IL-8 in the serum of infected chickens, and significantly increased the antibody levels of IgM, IgG, and NDV. In summary, schisandrin A exerted a disease-resistant effect against avian colibacillosis by modulating the immune response.

Key words: schisandrin A, chicken colibacillosis, immunity

CLC Number:

S853.7

Jialu BAO, Yan ZHANG, Xiaodan WANG. The Preventive Effect of Schisandrin A on Chicken Colibacillosis and Its Impact on Immune Function[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(10): 4735-4746.

Figures/Tables 7

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The Preventive Effect of Schisandrin A on Chicken Colibacillosis and Its Impact on Immune Function

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