常山散对雏鸡感染柔嫩艾美耳球虫不同发育阶段的防治效果

doi:10.11843/j.issn.0366-6964.2024.03.039

Abstract

Abstract: This experiment was conducted to study the effect of the Chinese herbal medicine Radix dichroa powder (RDP) on the anticoccidial effect and immune function of chick infected with Eimeria tenella at different developmental stages. Six major groups were set up in the trial, namely, 1 day before the attack, the day of the attack, day 2, day 3, day 4 and day 5 dosing time design groups, and each dosing time point included three treatment groups, namely group I (healthy control group) and group II (infected control group), fed the basal diet, and group III (RDP recommended dose group), fed at 0.1 g·kg^-1 in the basal diet and dosed continuously for 4 days, with 10 chicks in each group. At 16 days of age, 5×10⁴ sporulated oocysts of Eimeria tenella were administered orally to each chick in group II and group III. The results showed that compared with group I, the average daily gain (ADG) of group III was not significantly different (P> 0.05) in the early stage of coccidia development (1 day before and on the day of attack) and significantly decreased (P<0.05) in the late stage of development, while group II had significant decrease (P<0.05) in ADG throughout the period of coccidia development, and the decrease was greater than that of group III. Compared with group Ⅰ, the average daily feed intake (ADFI) decreased in both group Ⅱ and group Ⅲ, with the most significant decrease in group Ⅱ and improvement in group Ⅲ. Compared with group II, RDP significantly (P<0.05) reduced the number of fecal oocysts per gram (OPG) in infected chicks. Coccidia infection damaged the integrity of the cecum mucosa and thickened the cecum muscle membrane. The RDPof Chinese medicine reduced the mucosal damage caused by coccidial infection. Compared with group II, the addition of RDP in the diet reduced the cecum lesion score (P<0.05). The anticoccidial index (ACI) of group III were198.83, 190.23 and 165.49 on the 1st day before, the day of and the 2nd day of the attack, respectively, and 150.53, 155.00 and 146.18 on the 3rd, 4th and 5th day of the attack, respectively. The above results indicated that RDP had good anticoccidial effect when administered in the early stage of coccidial development, however as the coccidia developed in the body later, the therapeutic effect of RDP weakened. Compared with group II, RDP increased the levels of immunoglobulins IgA, IgM and IgG in blood, and improved the index of spleen and bursal. The results suggested that RDP improved the growth performance of infected chicks, significantly reduced the OPG and cecum lesion scores of infected chickens, and enhanced the immune function of infected chicks.

Key words: Chinese medicine, Radix dichroa powder, Eimeria tenella, chick

CLC Number:

WANG He, GUO Zhiting, LI Jianxi, ZHANG Jingyan, WANG Lei, ZHANG Kang, SUN Jiwen, SHANG Xiaofen, MA Yonghua. Effect of Radix dichroa Powder on the Control of Eimeria tenella Infection in Chick at Different Developmental Stages[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 1278-1289.

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Effect of Radix dichroa Powder on the Control of Eimeria tenella Infection in Chick at Different Developmental Stages

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