常山口服液治疗鸡球虫病的效果分析

doi:10.11843/j.issn.0366-6964.2024.04.036

Abstract

Abstract: In order to verify anticoccidial effect, optimal dosage and medication days of Changshan Oral Liquid (CSL), and lay the foundation for the application of new veterinary drug in future, the therapeutic effect analysis of experimental infected chicks and clinical cases of CSL on chicken coccidiosis were carried out. Healthy chicks were raised to 16 days under non-coccidiosis condition, and were randomly divided into six groups: healthy control group, infected control group, toltrazuril control group, and low dose group, medium dose group and high dose group of CSL (2.5, 5.0, and 10.0 mL·L^-1 drinking water respectively), 20 chicks were assigned in each group. Except for healthy control group, the rest groups were artificially infected with 6×10⁴ sporulated oocysts of Eimeria tenella (E. tenella) oocysts and the drugs were administered after 24 hours infection for 7 days. The clinical signs of chicks in each group were observed daily, such as spirit, feeding, drinking water and feces, etc. If there were dead chicks, they should be timely dissected to observe the anatomical changes, and anticoccidial index were calculated. Moreover, the chicks naturally infected with Eimeria oocysts were selected in the therapeutic effect analysis of clinical cases and divided into recommended dose group of CSL (5.0 mL·L^-1 drinking water) and toltrazuril control group, which were administered continuously for 4 days. The therapeutic effect analysis of experimental infected chicks showed that medium-dose and high-dose of CSL had good anticoccidial effect, anticoccidial index were 166.6 and 173.8 respectively. Besides, the doses above had good growth-promoting effect on chicks and relative weight gain were 119.8% and 101.6% respectively. The therapeutic effect analysis of clinical cases showed that CSL can effectively treat chicken coccidiosis. The cure rate and effective rate were 80.7% and 96.7% respectively. In the infected group, we found more Eimeria oocysts in cecal epithelial cells, lots of inflammatory cells and red blood cell in the tissues. In all drug groups, the chicken cecal structure were basically normal and intact. Our results suggest that CSL as a preparation of traditional Chinese medicine, has the characteristics of environmental protection and good anticoccidial effect, which has the potential to develop a new drug.

Key words: Radix dichroa, oral liquid, chicken coccidiosis, clinical trial

CLC Number:

S853.32

LUO Xiaoqin, GUO Zhiting, WANG He, ZHANG Jingyan, ZHANG Kang, WANG Lei, MA Yonghua, LI Jianxi. The Therapeutic Effect of Changshan Oral Liquid on Chicken Coccidiosis[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1747-1755.

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The Therapeutic Effect of Changshan Oral Liquid on Chicken Coccidiosis

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