Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (1): 201-212.doi: 10.11843/j.issn.0366-6964.2023.01.019
• ANIMAL BIOTECHNOLOGY AND REPRODUCTION • Previous Articles Next Articles
SANG Lei1,2, CHEN Dongjin1,2, SUN Shikun1,2, GAO Chengfang1,2, WANG Jinxiang1,2, CHEN Yanfeng1,2, XIE Xiping1,2*
Received:
2022-05-05
Online:
2023-01-23
Published:
2023-01-17
CLC Number:
SANG Lei, CHEN Dongjin, SUN Shikun, GAO Chengfang, WANG Jinxiang, CHEN Yanfeng, XIE Xiping. Cloning and Expression of GnIH Gene and Its Effect on Reproductive Hormones Secretion of Young Male Rabbits[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 201-212.
[1] | 《福建省地方畜禽品种资源志》编委会.福建省地方畜禽品种资源志[M].福州:福建科学技术出版社,2019.Editorial Board of Fujian Local Livestock and Poultry Variety Resources.Indigenous animal genetic resources in Fujian[M].Fuzhou:Fujian Science & Technology Publishing House,2019.(in Chinese) |
[2] | TSUTSUI K,SAIGOH E,UKENA K,et al.A novel avian hypothalamic peptide inhibiting gonadotropin release[J].Biochem Biophys Res Commun,2000,275(2):661-667. |
[3] | TSUTSUI K,UBUKA T,UKENA K.Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior[J].Front Neuroendocrinol,2022,64:100955. |
[4] | PINELLI C,SCANDURRA A,TSUTSUI K,et al.Comparative insights of the neuroanatomical distribution of the gonadotropin-inhibitory hormone (GnIH) in fish and amphibians[J].Front Neuroendocrinol,2022,65:100991. |
[5] | KHAMIS T,ABDELALIM A F,ABDALLAH S H,et al.Early intervention with breast milk mesenchymal stem cells attenuates the development of diabetic-induced testicular dysfunction via hypothalamic Kisspeptin/Kiss1r-GnRH/GnIH system in male rats[J].Biochim Biophys Acta Mol Basis Dis,2020,1866(1):165577. |
[6] | ZHANG X,LI M,HUANG M G,et al.Effect of RFRP-3,the mammalian ortholog of GnIH,on apoptosis and autophagy in porcine ovarian granulosa cells via the p38MAPK pathway[J].Theriogenology,2022,180:137-145. |
[7] | WILSTERMAN K,ALONGE M M,BAO X M,et al.Food access modifies GnIH,but not CRH,cell number in the hypothalamus in a female songbird[J].Gen Comp Endocrinol,2020,292:113438. |
[8] | MA Y,LADISA C,CHANG J P,et al.Multifactorial control of reproductive and growth axis in male goldfish:influences of GnRH,GnIH and thyroid hormone[J].Mol Cell Endocrinol,2020,500:110629. |
[9] | VAN WYK B,FRALEY G.Ontogeny of OPN4,OPN5,GnRH and GnIH mRNA expression in the posthatch male and female Pekin duck (Anas platyrhynchos domesticus) suggests OPN4 may have additional functions beyond reproduction[J].Animals (Basel),2021,11(4):1121. |
[10] | QASIMI M I,NAGAOKA K,WATANABE G.Feeding of phytosterols reduced testosterone production by modulating GnRH and GnIH expression in the brain and testes of male Japanese quail (Coturnix coturnix japonica)[J].Poult Sci,2018,97(3):1066-1072. |
[11] | ANJUM S,KRISHNA A,TSUTSUI K.Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice[J].J Endocrinol,2014,223(1):79-91. |
[12] | SOGA T,DALPATADU S L,WONG D W,et al.Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice[J].Neuroscience,2012,218:56-64. |
[13] | CLARKE I J,SMITH J T.The role of kisspeptin and gonadotropin inhibitory hormone (GnIH) in the seasonality of reproduction in sheep[J].Soc Reprod Fertil Suppl,2010,67:159-169. |
[14] | UBUKA T,MORGAN K,PAWSON A J,et al.Identification of human GnIH homologs,RFRP-1 and RFRP-3,and the cognate receptor,GPR147 in the human hypothalamic pituitary axis[J].PLoS One,2009,4(12):e8400. |
[15] | UBUKA T,LAI H,KITANI M,et al.Gonadotropin-inhibitory hormone identification,cDNA cloning,and distribution in rhesus macaque brain[J].J Comp Neurol,2009,517(6):841-855. |
[16] | CZAREZ-MRQUEZ F,LARAN-CHICH M P,KLOSEN P,et al.RFRP3 increases food intake in a sex-dependent manner in the seasonal hamster Phodopus sungorus[J].J Neuroendocrinol,2020,32(5):e12845. |
[17] | LAMM M S,LAMB A D,KLAPHEKE B P,et al.Characterization and distribution of kisspeptins,kisspeptin receptors,GnIH,and GnRH1 in the brain of the protogynous bluehead wrasse (Thalassoma bifasciatum)[J].J Chem Neuroanat,2022,121:102087. |
[18] | TSUTSUI K,UBUKA T.Gonadotropin-inhibitory hormone (GnIH):a new key neurohormone controlling reproductive physiology and behavior[J].Front Neuroendocrinol,2021,61:100900. |
[19] | 张克山,高广亮,李琴,等.NPFFR1基因对鹅卵泡颗粒细胞激素分泌和细胞凋亡的影响研究[J].畜牧兽医学报,2021, 52(10):2822-2831.ZHANG K S,GAO G L,LI Q,et al.The function of NPFFR1 on hormone secretion and apoptosis of follicle granulosa cell in geese[J].Acta Veterinaria et Zootechnica Sinica,2021,52(10):2822-2831.(in Chinese) |
[20] | 陈世健,刘文俊,杨晨,等.不同浓度GnIH对鸭颗粒细胞周期和增殖的影响[J].畜牧兽医学报,2021,52(1):116-125.CHEN S J,LIU W J,YANG C,et al.Effects of different concentrations of GnIH on cell cycle and proliferation of duck granulosa cells[J].Acta Veterinaria et Zootechnica Sinica,2021,52(1):116-125.(in Chinese) |
[21] | FERNANDES J R D,MOITRA A,TSUTSUI K,et al.Regulation of the hypothalamic GnRH-GnIH system by putrescine in adult female rats and GT1-7 neuronal cell line[J].J Exp Zool A Ecol Integr Physiol,2020,333(4):214-229. |
[22] | SUN W,LI S H,TIAN Z Z,et al.Dynamic changes of RFRP3/GPR147 in the precocious puberty model female rats[J].Curr Mol Med,2019,19(10):766-775. |
[23] | BENTLEY G E,TSUTSUI K,KRIEGSFELD L J.Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus,pituitary and gonads[J].Brain Res,2010,1364:62-71. |
[24] | 汤亚茹,阳美霞,贾金美,等.GnIH过表达载体构建及其对小鼠睾丸间质细胞的作用研究[J].畜牧兽医学报,2021, 52(10):2969-2977.TANG Y R,YANG M X,JIA J M,et al.Construction of GnIH overexpression vector and its effect on mouse Leydig cells[J].Acta Veterinaria et Zootechnica Sinica,2021,52(10):2969-2977.(in Chinese) |
[25] | UBUKA T,UENO M,UKENA K,et al.Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system[J].J Endocrinol,2003,178(2):311-318. |
[26] | HINUMA S,SHINTANI Y,FUKUSUMI S,et al.New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals[J].Nat Cell Biol,2000,2(10):703-708. |
[27] | LI X,SU J,LEI Z H,et al.Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig:cDNA cloning,expression in tissues and expression pattern in the reproductive axis during the estrous cycle[J].Peptides,2012,36(2):176-185. |
[28] | 刘晶.兔GnIH及其受体基因的克隆和mRNA在组织器官的表达[D].南京:南京农业大学,2011:29-37.LIU J.The cloning and mRNA expression of GnIH and its receptors in rabbit[D].Nanjing:Nanjing Agricultural University, 2011:29-37.(in Chinese) |
[29] | UBUKA T,PARHAR I.Dual actions of mammalian and piscine gonadotropin-inhibitory hormones,RFamide-related peptides and LPXRFamide peptides,in the hypothalamic-pituitary-gonadal axis[J].Front Endocrinol (Lausanne),2017,8:377. |
[30] | DIXIT A S,BYRSAT S,SINGH N S.Circadian rhythm in photoperiodic expressions of GnRH-I and GnIH regulating seasonal reproduction in the Eurasian tree sparrow,Passer montanus[J].J Photochem Photobiol B Biol,2020,211:111993. |
[31] | WANG X Y,LI X,HU C H.Distribution of gonadotropin-inhibitory hormone (GnIH) in male Luchuan piglets[J].Gene Expr Patterns,2018,28:42-53. |
[32] | BANERJEE S,SHAHIN S,CHATURVEDI C M.Age dependent variations in the deep brain photoreceptors (DBPs), GnRH-GnIH system and testicular steroidogenesis in Japanese quail,Coturnix coturnix japonica[J].Exp Gerontol,2018, 108:7-17. |
[33] | DIXIT A S,BYRSAT S,KATAKI B.Hypothalamic expression of GnRH-I and GnIH in the Eurasian tree sparrow over a single long day[J].Photochem Photobiol Sci,2022,21(2):147-158. |
[34] | TEO C H,SOGA T,PARHAR I.Lithium chloride enhances serotonin induced calcium activity in EGFP-GnIH neurons[J].Sci Rep,2020,10(1):13876. |
[35] | WANG H M,KHORADMEHR A,JALALI M,et al.The roles of RFamide-related peptides (RFRPs),mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction[J].Iran J Basic Med Sci,2018,21(12):1210-1220. |
[36] | HAN X F,LI J L,CAO X H,et al.Surgical castration but not immuncastration is associated with reduced hypothalamic GnIH and GHRH/GH/IGF-I axis function in male rats[J].Theriogenology,2016,86(2):657-665. |
[37] | CALISI R M,GERAGHTY A C,AVILA A,et al.Patterns of hypothalamic GnIH change over the reproductive period in starlings and rats[J].Gen Comp Endocrinol,2016,237:140-146. |
[38] | ZHAO L,ZHONG M,XUE H L,et al.Effect of RFRP-3 on reproduction is sex-and developmental status-dependent in the striped hamster (Cricetulus barabensis)[J].Gene,2014,547(2):273-279. |
[39] | ZHENG L C,SU J,FANG R,et al.Developmental changes in the role of gonadotropin-inhibitory hormone (GnIH) and its receptors in the reproductive axis of male Xiaomeishan pigs[J].Anim Reprod Sci,2015,154:113-120. |
[40] | CHOI Y J,HABIBI H R,CHOI C Y.Profiles of gonadotropin-inhibitory hormone and melatonin during the sex change and maturation of cinnamon clownfish,Amphiprion melanopus[J].Biochem Biophys Res Commun,2016,475(2):189-193. |
[41] | DUCRET E,ANDERSON G M,HERBISON A E.RFamide-related peptide-3,a mammalian gonadotropin-inhibitory hormone ortholog,regulates gonadotropin-releasing hormone neuron firing in the mouse[J].Endocrinology,2009,150(6):2799-2804. |
[42] | WANG H M,BU S Y,TANG J J,et al.PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis[J].FASEB J,2021,35(8):e21756. |
[43] | KOKLIČ T,HROVAT A,GUIXÀ-GONZLEZ R,et al.Electron paramagnetic resonance gives evidence for the presence of type 1 gonadotropin-releasing hormone receptor (GnRH-R) in subdomains of lipid rafts[J].Molecules,2021,26(4):973. |
[44] | XIANG W,ZHANG B Y,LV F L,et al.The inhibitory effects of RFamide-related peptide 3 on luteinizing hormone release involves an estradiol-dependent manner in prepubertal but not in adult female mice[J].Biol Reprod,2015,93(2):30. |
[45] | IQBAL J,LATCHOUMANIN O,SARI I P,et al.Estradiol-17β inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release[J].Endocrinology,2009,150(9):4213-4220. |
[46] | RUDOLF F O,KADOKAWA H.Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells[J].J Reprod Dev,2016,62(1):65-69. |
[47] | CHEN H P,CUI X F,WANG Y R,et al.Identification,functional characterization,and estrogen regulation on gonadotropin-releasing hormone in the spotted scat,Scatophagus argus[J].Fish Physiol Biochem,2020,46(5):1743-1757. |
[48] | REN X L,HUANG Y L,LI X M,et al.Identification and functional characterization of gonadotropin-releasing hormone in pompano (Trachinotus ovatus)[J].Gen Comp Endocrinol,2022,316:113958. |
[49] | SHAHJAHAN M,IKEGAMI T,OSUGI T,et al.Synchronised expressions of LPXRFamide peptide and its receptor genes:seasonal, diurnal and circadian changes during spawning period in grass puffer[J].J Neuroendocrinol,2011,23(1):39-51. |
[50] | HENNINGSEN J B,GAUER F,SIMONNEAUX V.RFRP neurons-the doorway to understanding seasonal reproduction in mammals[J].Front Endocrinol (Lausanne),2016,7:36. |
[1] | YANG Yang, YU Qian, LIU Yucheng, YANG Hua, ZHAO Zhuo, WANG Limin, ZHOU Ping, YANG Qingyong, DAI Rong. Identification and Tissue Expression Analysis of the Sheep MYL Gene Family [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1551-1564. |
[2] | HUANG Xianpeng, XING Jiayi, BAI Yuanyuan, JIANG Yuting, MA Zhiwei, FU Wei, LAN Daoliang. Cloning of Six Pluripotent Related Transcription Factors OSKMNL in Yak and Construction of Polycistron Lentiviral Vector [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1579-1591. |
[3] | KANG Jia, DUAN Xiangru, YIN Xuejiao, YANG Ruochen, LI Taichun, SHAN Xinyu, CHEN Meijing, ZHANG Yingjie, LIU Yueqin. Effects of Cysteine and Methionine on Secondary Hair Follicle Growth and Hair Dermal Papilla Cell Proliferation in vitro in Cashmere Goats [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 515-527. |
[4] | SHAO Yuexin, ZHANG Xinyu, GE Liyan, SHI Huaiping. Cloning and RNA Interference Analysis of ATF4 Gene in Xinong Saanen Dairy Goat [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2353-2364. |
[5] | CHEN Cancan, JIANG Jing, SUN Xiaoyan, REN Hangxing, LI Jie. Expression of AGRP Gene in Goat Tissue and Its Action Mechanism on Melanin Production [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1441-1451. |
[6] | XING Wenwen, QI Nannan, LI Mengxuan, LIU Jiying. Research Progress on the Mechanism of YY1 and Its Role in the Regulation of Animal Reproduction [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4040-4049. |
[7] | JI Zhengyu, NI Mengru, ZHANG Zhaobo, ZHAO Gan, HUANG Zan, LI Pinghua, HUANG Ruihua, HOU Liming. Research on Adipogenic Capacity and Gene Expression Pattern of in Vitro FAPs Cells Derived from Longissimus Dorsi Muscle of Suhuai Pig [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4126-4142. |
[8] | YANG Yang, ZHOU Ziwei, ZHANG Jingyi, YANG Shuo, WANG Boyu, GE Nan, LIN Ye, HOU Xiaoming. Analysis on SP1 Gene Structure and Its Function on Milk Fat Synthesis in Holstein Dairy Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 2970-2981. |
[9] | LUORENG Zhuoma, WANG Jinpeng, JIAO Peng, LI Yanxia, DONG Yiwen, WEI Dawei, WNAG Xingping. Construction of Dairy Cow Mastitis Model and Analysis of mRNA Transcription Level of Inflammation Related Cytokine Genes [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2763-2772. |
[10] | YANG Hongzao, ZHU Jie, GUO Hongyuan, TANG Aoxing, CHEN Shaoyu, LIU Chuncao, ZHANG Da, YUAN Ligang, LIU Guangqing. Expression and Subcellular Localization Analysis of Felis catus C11orf96 [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2390-2395. |
[11] | LIU Kehan, WANG Yong, LI Yanyan, WANG Chongyang, ZHU Jiangjiang, XIONG Yan, LI An, LIN Yaqiu. Effects of SRSF10 on the Differentiation of Intramuscular Preadipocytes in Goats [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1768-1778. |
[12] | LI Yu, DUAN Chunhui, SONG Zhipan, YUE Sicong, WANG Yuan, ZHANG Yingjie, LIU Yueqin. Effects of PGF2α on Reproductive Hormones and Related Cytokines during Luteal Phase in Ewes [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1807-1818. |
[13] | YU Yongtao, MAO Yanni, ZHAO Qingmei, LI Jinrong, BAI Xiaonan, XUE Jiaqi, ZHANG Haodong. Expression Pattern Analysis of Related Genes in SWN Gene Cluster of Alternaria oxytropis Mutated by Ethyl Methylate [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(4): 1241-1251. |
[14] | LI Yan, LAN Tingying, PANG Bo, YANG Xiaonong, HUANG Jian. Expression of NLRP3 Inflammasome Signal Associated Genes in Canine Mammary Tumors and Clinical Significance [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(4): 1252-1258. |
[15] | LIU Yue, XUE Xianglan, LI Xiaobo, JIANG Lin, PU Yabin, HE Xiaohong, MA Yuehui, ZHAO Qianjun. Research Progress of the Relationship between Chromatin Accessibility and Animal Embryo Development [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(3): 680-687. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||