染色质开放性与动物胚胎发育关系的研究进展

doi:10.11843/j.issn.0366-6964.2022.03.002

Abstract

Abstract: Chromatin accessibility refers to the openness of proteins such as nucleosomes or transcription factors to the recombination of other proteins after binding to eukaryotic chromatin DNA, which can reflect transcriptional activity. Open chromatin is closely related to animal growth and development, cell differentiation and other processes. The efficient and accurate localization of open chromatin in the genome can provide vital clues for exploring the regulation mechanism of gene expression. In this paper, the methods of chromatin accessibility detection and the factors of chromatin accessibility are introduced, and the effects of chromatin accessibility on animal development and its development and application prospects are discussed so as to provide a reference for related studies on gene expression regulation during animal development.

Key words: chromatin accessibility, epigenetics, gene expression, embryonic development

CLC Number:

S813.2

LIU Yue, XUE Xianglan, LI Xiaobo, JIANG Lin, PU Yabin, HE Xiaohong, MA Yuehui, ZHAO Qianjun. Research Progress of the Relationship between Chromatin Accessibility and Animal Embryo Development[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(3): 680-687.

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Research Progress of the Relationship between Chromatin Accessibility and Animal Embryo Development

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