山羊环境适应性的研究进展

doi:10.11843/j.issn.0366-6964.2022.07.001

Abstract

Abstract: As one of the important livestock, the goat not only provide abundant materials for human beings, such as milk, meat and wool, but also have good adaptability to live in extreme environment such as heat, cold and drought areas. However, the molecular mechanism of environmental adaptability has not been fully explained in goats. With the development of sequencing technology and the rise of landscape genomics, genetic environment association analysis has been carried out in many studies, and a series of candidate genes related to environmental adaptability have been reported, which provided an important basis for analyzing the genetic mechanism of environmental adaptability in goats. This review introduces the methods of genetic environment association analysis from the perspective of landscape genomics, including classification test, logistic regression, general linear model and mixed-effect model. In view of the current situation of environmental adaptability in goats, the research progress in recent years was summarized from 5 aspects:high altitude adaptability, heat adaptability, cold adaptability, drought adaptability and comprehensive climate adaptability. Finally, this paper pointed out the existing problems in the study of environmental adaptability in goats, and prospected the future research trends, in order to provide a theoretical basis for collecting, protecting and utilizing the goat genetic resources.

Key words: environmental adaptability, goat, genetic variation, genetic environment association analysis

CLC Number:

S827

ZHANG Zhengkai, LI Yefang, YE Shaohui, JIANG Lin, MA Yuehui. Research Progress of Environmental Adaptability in Goats[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2035-2046.

References 89

[1]	ERWIN D H.Climate as a driver of evolutionary change[J].Curr Biol,2009,19(14):R575-R583.
[2]	GARCIA R A,CABEZA M,RAHBEK C,et al.Multiple dimensions of climate change and their implications for biodiversity[J].Science,2014,344(6183):1247579.
[3]	TERÉS J,BUSOMS S,MARTÍN L P,et al.Soil carbonate drives local adaptation in Arabidopsis thaliana[J].Plant Cell Environ, 2019, 42(8):2384-2398.
[4]	TYRMI J S,VUOSKU J,ACOSTA J J,et al.Genomics of Clinal local adaptation in Pinus sylvestris under continuous environmental and spatial genetic setting[J].G3(Bethesda),2020,10(8):2683-2696.
[5]	MWACHARO J M,KIM E S,ELBELTAGY A R,et al.Genomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohorts[J].Sci Rep,2017,7(1):17647.
[6]	WITT K E,HUERTA-SÁNCHEZ E.Convergent evolution in human and domesticate adaptation to high-altitude environments[J].Philos Trans R Soc Lond B Biol Sci,2019,374(1777):20180235.
[7]	DALY K G,DELSER P M,MULLIN V E,et al.Ancient goat genomes reveal mosaic domestication in the Fertile Crescent[J]. Science,2018,361(6397):85-88.
[8]	LI X,YANG J,SHEN M,et al.Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits[J].Nat Commun,2020,11(1):2815.
[9]	FRANTZ L A F,HAILE J,LIN A T,et al.Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe[J].Proc Natl Acad Sci U S A,2019,116(35):17231-17238.
[10]	QIU Q,WANG L Z,WANG K,et al.Yak whole-genome resequencing reveals domestication signatures and prehistoric population expansions[J].Nat Commun,2015,6:10283.
[11]	LIU X X,ZHANG Y L,LI Y F,et al.EPAS1 gain-of-function mutation contributes to high-altitude adaptation in Tibetan horses[J].Mol Biol Evol,2019,36(11):2591-2603.
[12]	MCHUGO G P,DOVER M J,MACHUGH D E.Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics[J].BMC Biol,2019,17(1):98.
[13]	EVENO E,COLLADA C,GUEVARA M A,et al. "Contrasting patterns of selection at Pinus pinaster Ait. Drought stress candidate genes as revealed by genetic differentiation analyses"[J].Mol Biol Evol,2008,25(2):417-437.
[14]	HOBAN S,KELLEY J L,LOTTERHOS K E,et al.Finding the genomic basis of local adaptation:pitfalls,practical solutions,and future directions[J].Am Nat,2016,188(4):379-397.
[15]	RELLSTAB C,GUGERLI F,ECKERT A J,et al.A practical guide to environmental association analysis in landscape genomics[J].Mol Ecol,2015,24(17):4348-4370.
[16]	LV F H,AGHA S,KANTANEN J,et al.Adaptations to climate-mediated selective pressures in sheep[J].Mol Biol Evol, 2014, 31(12):3324-3343.
[17]	SORK V L.Genomic studies of local adaptation in natural plant populations[J].J Hered,2017,109(1):3-15.
[18]	FITZPATRICK M C,KELLER S R.Ecological genomics meets community-level modelling of biodiversity:mapping the genomic landscape of current and future environmental adaptation[J].Ecol Lett,2015,18(1):1-16.
[19]	ZEDER M A.Domestication and early agriculture in the Mediterranean Basin:origins,diffusion,and impact[J].Proc Natl Acad Sci U S A,2008,105(33):11597-11604.
[20]	PIDANCIER N,JORDAN S,LUIKART G,et al.Evolutionary history of the genus Capra (Mammalia,Artiodactyla):discordance between mitochondrial DNA and Y-chromosome phylogenies[J].Mol Phylogenet Evol,2006,40(3):739-749.
[21]	AMILLS M,CAPOTE J,TOSSER-KLOPP G.Goat domestication and breeding:a jigsaw of historical,biological and molecular data with missing pieces[J].Anim Genet,2017,48(6):631-644.
[22]	GILBERT M,NICOLAS G,CINARDI G,et al.Global distribution data for cattle,buffaloes,horses,sheep,goats,pigs,chickens and ducks in 2010[J].Sci Data,2018,5:180227.
[23]	NAIR M R R,SEJIAN V,SILPA M V,et al.Goat as the ideal climate-resilient animal model in tropical environment:revisiting advantages over other livestock species[J].Int J Biometeorol,2021,65(12):2229-2240.
[24]	ZHANG M H,DUNSHEA F R,WARNER R D,et al.Impacts of heat stress on meat quality and strategies for amelioration:a review[J].Int J Biometeorol,2020,64(9):1613-1628.
[25]	CAO Y H,XU S S,SHEN M,et al.Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep[J].Mol Biol Evol,2021,38(3):838-855.
[26]	国家生态科学数据中心[Z].2019.National Ecosystem Science Data Center[Z].2019.(in Chinese)
[27]	资源环境科学与数据中心[Z]. Resource and Environment Science and Data Center[Z].(in Chinese)
[28]	WorldClim[Z].
[29]	VAN DIJK E L,AUGER H,JASZCZYSZYN Y,et al.Ten years of next-generation sequencing technology[J].Trends Genet,2014,30(9):418-426.
[30]	WORLEY K C.A golden goat genome[J].Nat Genet,2017,49(4):485-486.
[31]	MANEL S,HOLDEREGGER R.Ten years of landscape genetics[J].Trends Ecol Evol,2013,28(10):614-621.
[32]	MANEL S,ANDRELLO M,HENRY K,et al.Predicting genotype environmental range from genome-environment associations[J].Mol Ecol,2018,27(13):2823-2833.
[33]	LI X,GUO T T,MU Q,et al.Genomic and environmental determinants and their interplay underlying phenotypic plasticity[J].Proc Natl Acad Sci U S A,2018,115(26):6679-6684.
[34]	MANEL S,PERRIER C,PRATLONG M,et al.Genomic resources and their influence on the detection of the signal of positive selection in genome scans[J].Mol Ecol,2016,25(1):170-184.
[35]	FOLL M,GAGGIOTTI O.A genome-scan method to identify selected loci appropriate for both dominant and codominant markers:a Bayesian perspective[J].Genetics,2008,180(2):977-993.
[36]	BONHOMME M,CHEVALET C,SERVIN B,et al.Detecting selection in population trees:the Lewontin and Krakauer test extended[J].Genetics,2010,186(1):241-262.
[37]	YANG J,LI W R,LV F H,et al.Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments[J].Mol Biol Evol,2016,33(10):2576-2592.
[38]	GHEYAS A A,VALLEJO-TRUJILLO A,KEBEDE A,et al.Integrated environmental and genomic analysis reveals the drivers of local adaptation in African indigenous chickens[J].Mol Biol Evol,2021,38(10):4268-4285.
[39]	DE MITA S,THUILLET A C,GAY L,et al.Detecting selection along environmental gradients:analysis of eight methods and their effectiveness for outbreeding and selfing populations[J].Mol Ecol,2013,22(5):1383-1399.
[40]	JOOST S,BONIN A,BRUFORD M W,et al.A spatial analysis method (SAM) to detect candidate loci for selection:towards a landscape genomics approach to adaptation[J].Mol Ecol,2007,16(18):3955-3969.
[41]	JOOST S,KALBERMATTEN M,BONIN A.Spatial analysis method (SAM):a software tool combining molecular and environmental data to identify candidate loci for selection[J].Mol Ecol Resour,2008,8(5):957-960.
[42]	DURUZ S,SEVANE N,SELMONI O,et al.Rapid identification and interpretation of gene-environment associations using the new R.SamBada landscape genomics pipeline[J].Mol Ecol Resour,2019,19(5):1355-1365.
[43]	STUCKI S,OROZCO-TERWENGEL P,FORESTER B R,et al.High performance computation of landscape genomic models including local indicators of spatial association[J].Mol Ecol Resour,2017,17(5):1072-1089.
[44]	OKSANEN J,BLANCHET F G,FRIENDLY M,et al.vegan:community Ecology Package.Ordination methods,diversity analysis and other functions for community and vegetation ecologists.Version 2.5-7[Z].2020.
[45]	BLANCO-PASTOR J L,BARRE P,KEEP T,et al.Canonical correlations reveal adaptive loci and phenotypic responses to climate in perennial ryegrass[J].Mol Ecol Resour,2021,21(3):849-870.
[46]	MOSCA E,ECKERT A J,DI PIERRO E A,et al.The geographical and environmental determinants of genetic diversity for four alpine conifers of the European Alps[J].Mol Ecol,2012,21(22):5530-5545.
[47]	CAPBLANCQ T,LUU K,BLUM M,et al.Evaluation of redundancy analysis to identify signatures of local adaptation[J].Mol Ecol Resour,2018,18(6):1223-1233.
[48]	LASKY J R,DES MARAIS D L,LOWRY D B,et al.Natural variation in abiotic stress responsive gene expression and local adaptation to climate in Arabidopsis thaliana[J].Mol Biol Evol,2014,31(9):2283-2296.
[49]	MDLADLA K,DZOMBA E F,MUCHADEYI F C.Landscape genomics and pathway analysis to understand genetic adaptation of South African indigenous goat populations[J].Heredity (Edinb),2018,120(4):369-378.
[50]	FRICHOT E,SCHOVILLE S D,BOUCHARD G,et al.Testing for associations between loci and environmental gradients using latent factor mixed models[J].Mol Biol Evol,2013,30(7):1687-1699.
[51]	SERRANITO B,TAURISSON-MOURET D,HARKAT S,et al.Search for selection signatures related to trypanosomosis tolerance in African goats[J].Front Genet,2021,12:715732.
[52]	GAIN C,FRANÇOIS O.LEA 3:factor models in population genetics and ecological genomics with R[J].Mol Ecol Resour, 2021, 21(8):2738-2748.
[53]	CAYE K,JUMENTIER B,LEPEULE J,et al.LFMM 2:fast and accurate inference of gene-environment associations in genome-wide studies[J].Mol Biol Evol,2019,36(4):852-860.
[54]	BEALL C M.Two routes to functional adaptation:Tibetan and Andean high-altitude natives[J].Proc Natl Acad Sci U S A,2007,104 Suppl 1(Suppl 1):8655-8660.
[55]	WEST J B.Early history of high-altitude physiology[J].Ann N Y Acad Sci,2016,1365(1):33-42.
[56]	LUKS A M,SWENSON E R,BARTSCH P.Acute high-altitude sickness[J].Eur Respir Rev,2017,26(143):160096.
[57]	SIMONSON T S,YANG Y Z,HUFF C D,et al.Genetic evidence for high-altitude adaptation in Tibet[J].Science, 2010, 329(5987):72-75.
[58]	ZHANG W P,FAN Z X,HAN E J,et al.Hypoxia adaptations in the grey wolf (Canis lupus chanco) from Qinghai-Tibet Plateau[J].PLoS Genet,2014,10(7):e1004466.
[59]	张天留,高雪,徐凌洋,等.高原家养动物环境适应性的研究进展[J].畜牧兽医学报,2020,51(7):1475-1487.ZHANG T L,GAO X,XU L Y,et al.Research progress on environment adaptation of plateau domestic animals[J].Acta Veterinaria et Zootechnica Sinica,2020,51(7):1475-1487.(in Chinese)
[60]	WANG X L,LIU J,ZHOU G X,et al.Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits[J].Sci Rep,2016,6:38932.
[61]	GUO J Z,TAO H X,LI P F,et al.Whole-genome sequencing reveals selection signatures associated with important traits in six goat breeds[J].Sci Rep,2018,8(1):10405.
[62]	SONG S,YAO N,YANG M,et al.Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus)[J].BMC Genomics,2016,17:122.
[63]	LORENZO F R,HUFF C,MYLLYMÄKI M,et al.A genetic mechanism for Tibetan high-altitude adaptation[J].Nat Genet,2014,46(9):951-956.
[64]	GOU X,WANG Z,LI N,et al.Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia[J].Genome Res,2014,24(8):1308-1315.
[65]	WU D D,YANG C P,WANG M S,et al.Convergent genomic signatures of high-altitude adaptation among domestic mammals[J].Natl Sci Rev,2020,7(6):952-963.
[66]	BERMAN A.Invited review:are adaptations present to support dairy cattle productivity in warm climates?[J].J Dairy Sci,2011, 94(5):2147-2158.
[67]	BERNABUCCI U,BIFFANI S,BUGGIOTTI L,et al.The effects of heat stress in Italian Holstein dairy cattle[J].J Dairy Sci,2014,97(1):471-486.
[68]	KOCH F,THOM U,ALBRECHT E,et al.Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine[J].Proc Natl Acad Sci U S A,2019,116(21):10333-10338.
[69]	SILVA P S,HOOPER H B,MANICA E,et al.Heat stress affects the expression of key genes in the placenta,placental characteristics,and efficiency of Saanen goats and the survival and growth of their kids[J].J Dairy Sci,2021,104(4):4970-4979.
[70]	GUO J Z,ZHONG J,LI L,et al.Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds[J].Genet Sel Evol,2019,51:70.
[71]	GONZALEZ-RIVAS P A,CHAUHAN S S,HA M,et al.Effects of heat stress on animal physiology,metabolism,and meat quality:a review[J].Meat Sci,2020,162:108025.
[72]	BENJELLOUN B,ALBERTO F J,STREETER I,et al.Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data[J].Front Genet,2015,6:107.
[73]	KIM E S,ELBELTAGY A R,ABOUL-NAGA A M,et al.Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment[J].Heredity (Edinb),2016,116(3):255-264.
[74]	BRITO L F,KIJAS J W,VENTURA R V,et al.Genetic diversity and signatures of selection in various goat breeds revealed by genome-wide SNP markers[J].BMC Genomics,2017,18(1):229.
[75]	BERTOLINI F,SERVIN B,TALENTI A,et al.Signatures of selection and environmental adaptation across the goat genome post-domestication[J].Genet Sel Evol,2018,50(1):57.
[76]	GEERTS S,OSAER S,GOOSSENS B,et al.Trypanotolerance in small ruminants of sub-Saharan Africa[J].Trends Parasitol, 2009, 25(3):132-138.
[77]	GUTIERREZ C,CORBERA J A,MORALES M,et al.Trypanosomosis in goats:current status[J].Ann N Y Acad Sci,2006, 1081:300-310.
[78]	LUO N J,WANG J,HU Y,et al.Cold and heat climatic variations reduce indigenous goat birth weight and enhance pre-weaning mortality in subtropical monsoon region of China[J].Trop Anim Health Prod,2020,52(3):1385-1394.
[79]	DO PRADO PAIM T,BORGES B O,DE MELLO T L P,et al.Thermographic evaluation of climatic conditions on lambs from different genetic groups[J].Int J Biometeorol,2013,57(1):59-66.
[80]	WANG F H,ZHANG L,GONG G,et al.Genome-wide association study of fleece traits in Inner Mongolia Cashmere goats[J].Anim Genet,2021,52(3):375-379.
[81]	BURREN A,NEUDITSCHKO M,SIGNER-HASLER H,et al.Genetic diversity analyses reveal first insights into breed-specific selection signatures within Swiss goat breeds[J].Anim Genet,2016,47(6):727-739.
[82]	GUERRERO A I,ROGERS T L.From low to high latitudes:changes in fatty acid desaturation in mammalian fat tissue suggest a thermoregulatory role[J].BMC Evol Biol,2019,19(1):155.
[83]	VIRTANEN K A,LIDELL M E,ORAVA J,et al.Functional brown adipose tissue in healthy adults[J].N Engl J Med,2009, 360(15):1518-1525.
[84]	VAN MARKEN LICHTENBELT W D,VANHOMMERIG J W,SMULDERS N M,et al.Cold-activated brown adipose tissue in healthy men[J].N Engl J Med,2009,360(15):1500-1508.
[85]	FULLER-JACKSON J P,HENRY B A.Adipose and skeletal muscle thermogenesis:studies from large animals[J].J Endocrinol,2018,237(3):R99-R115.
[86]	WANG L J,CHEN X Y,SONG T Z,et al.Using RNA-Seq to identify reference genes of the transition from brown to white adipose tissue in goats[J].Animals,2020,10(9):1626.
[87]	LI X K,SU R,WAN W T,et al.Identification of selection signals by large-scale whole-genome resequencing of cashmere goats[J].Sci Rep,2017,7(1):15142.
[88]	SELEIMAN M F,AL-SUHAIBANI N,ALI N,et al.Drought stress impacts on plants and different approaches to alleviate its adverse effects[J].Plants (Basel),2021,10(2):259.
[89]	CORTELLARI M,BARBATO M,TALENTI A,et al.The climatic and genetic heritage of Italian goat breeds with genomic SNP data[J].Sci Rep,2021,11(1):10986.

Research Progress of Environmental Adaptability in Goats

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