HuR的功能及其对肌肉生长发育的调控作用

doi:10.11843/j.issn.0366-6964.2022.05.003

Abstract

Abstract: The RNA binding protein HuR (human antigen R), also known as ELAV like RNA binding protein 1 (ELAV1), is an important RNA binding protein widely expressed in various tissues of the body, which is involved in various biological activities through the regulation of pre-mRNA splicing, polyadenylation, as well as mRNA stability and translational efficiency. Studies have shown that RNA binding proteins are involved in the regulation of muscle growth and development, in which HuR is involved in regulating myogenesis and the occurrence of muscle diseases mainly by affecting the stability and translation of target mRNAs. Combined with the related research of HuR in recent years, this paper reviews the biological characteristics, main functions and modes of action of HuR, and its regulatory role in muscle growth and development and related diseases, in order to provide reference for the further study of the role of HuR in the regulation of muscle growth and development.

Key words: HuR, function, muscle growth and development, disease, mechanism of action

CLC Number:

S852.2

SUN Yanjin, XUE Ya’nan, ZHONG Tao, WANG Linjie, LI Li, ZHANG Hongping, ZHAN Siyuan. The Function of HuR and Its Regulation on Muscle Growth and Development[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1345-1353.

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The Function of HuR and Its Regulation on Muscle Growth and Development

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