恶性疟原虫ApiAP2蛋白质家族研究进展

doi:10.11843/j.issn.0366-6964.2022.05.004

Abstract

Abstract: Malaria is a zoonosis caused by Plasmodium which belongs to Apicomplexan. Plasmodium can not only infect human beings, but also poultries, mice, cynomolgus macaques and many kinds of animals, among which Plasmodium gallinaceum and rodent malaria have a great impact on animal husbandry. Plasmodium requires a strict gene regulation to complete its complex life cycle and transcription factors play very essential roles in regulating gene expression. Up to now, apicomplexan AP2 (ApiAP2) family is the only candidate that appears as transcription factors in Apicomplexan. On the basis of summarizing the previous studies, this article predicts the regulatory mechanism that the function of proteins is unknown in ApiAP2 family of Plasmodium falciparum, also explores the prospect of the post-translational modification in ApiAP2 family, which provides reference for animal husbandry to develop vaccine of protozoal diseases.

Key words: malaria, Plasmodium falciparum, ApiAP2 protein family, gene regulation, transcription factor, post-translational modification

CLC Number:

S852.729

ZHENG Yuxin, ZHANG Yiwei, JIANG Ning. Research Advance on ApiAP2 Family of Plasmodium falciparum[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1354-1363.

References 33

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Research Advance on ApiAP2 Family of Plasmodium falciparum

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