奶牛胃肠道菌群与奶牛乳房炎关联性及其对乳房炎调控潜力的研究进展

doi:10.11843/j.issn.0366-6964.2021.08.002

Abstract

Abstract: Bovine mastitis is one of the diseases that seriously affect the body health status and milk quality of dairy cows. The infection of mammary gland caused by the invasion of exogenous pathogenic bacteria has long been considered to be the main factor of bovine mastitis. However, recent studies have shown that the gastrointestinal microorganisms can also influence and regulate the development of mastitis. The main mechanism may involve the entero-mammary pathway, that is, certain bacteria from the gastrointestinal tract may migrate to the mammary gland via an endogenous cellular pathway through a mechanism involving monocytes (mainly phagocytes). In this review, the pathogenic factors of bovine mastitis and its influence, the relationship between gastrointestinal microflora and mastitis as well as the regulation of gastrointestinal microbiome on mastitis (including dietary, short-chain fatty acids (SCFAs), probiotics and commensal bacteria) etc., were reviewed, aiming to provide several new information for the pathogenesis and mitigation measures of bovine mastitis.

Key words: dairy cow, mastitis, gastrointestinal microbiota, entero-mammary endogenous pathway

CLC Number:

WANG Yue, NAN Xuemei, JIANG Linshu, XIONG Benhai. Research Progress on the Correlation between Gastrointestinal Microbiota and Bovine Mastitis in Dairy Cows and Its Regulatory Potential for Mastitis[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2083-2092.

References 61

[1]	BOCHNIARZ M,SZCZUBIA M,BRODZKI P,et al.Serum amyloid A as an marker of cow's mastitis caused by Streptococcus sp.[J].Comp Immunol Microbiol Infect Dis,2020,72:101498.
[2]	DOEHRING C,SUNDRUM A.The informative value of an overview on antibiotic consumption,treatment efficacy and cost of clinical mastitis at farm level[J].Prev Vet Med,2019,165:63-70.
[3]	ZHANG L,BOEREN S,VAN HOOIJDONK A C M,et al.A proteomic perspective on the changes in milk proteins due to high somatic cell count[J].J Dairy Sci,2015,98(8):5339-5351.
[4]	ADDIS M F,TANCA A,UZZAU S,et al.The bovine milk microbiota:insights and perspectives from -omics studies[J].Mol Biosyst,2016,12(8):2359-2372.
[5]	MA C,SUN Z,ZENG B,et al.Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis[J].Microbiome,2018,6(1):200-217.
[6]	KAMADA N,SEO S U,CHEN G Y,et al.Role of the gut microbiota in immunity and inflammatory disease[J].Nat Rev Immunol,2013,13(5):321-335.
[7]	HONDA K,LITTMAN D R.The microbiome in infectious disease and inflammation[J].Annu Rev Immunol,2012,30:759-795.
[8]	ZHONG Y F,XUE M Y,LIU J X.Composition of rumen bacterial community in dairy cows with different levels of somatic cell counts[J].Front Microbiol,2018,9:3217.
[9]	WANG Y,NAN X M,ZHAO Y G,et al.Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis[J].J Anim Sci Biotechnol,2021,12(1):36.
[10]	SHIVELY C A,REGISTER T C,APPT S E,et al.Consumption of mediterranean versus western diet leads to distinct mammary gland microbiome populations[J].Cell Rep,2018,25(1):47-56.
[11]	RICHARDS J L,YAP Y A,MCLEOD K H,et al.Dietary metabolites and the gut microbiota:an alternative approach to control inflammatory and autoimmune diseases[J].Clin Transl Immunol,2016,5(5):e82.
[12]	RAINARD P,FOUCRAS G.A critical appraisal of probiotics for mastitis control[J].Front Vet Sci,2018,5:251.
[13]	BUITENHUIS B,RØNTVED C M,EDWARDS S M,et al.In depth analysis of genes and pathways of the mammary gland involved in the pathogenesis of bovine Escherichia coli-mastitis[J].BMC Genomics,2011,12(1):130.
[14]	LEITE R F,BACCILI C C,DA COSTA E SILVA C P,et al.Passive immunity transfer in calves fed with colostrum from dams with subclinical mastitis[J/OL].Arq Inst Biol,2017,84[2021-05-11].http://dx.doi.org/10.1590/1808-1657000022015.
[15]	GAO J,BARKEMA H W,ZHANG L M,et al.Incidence of clinical mastitis and distribution of pathogens on large Chinese dairy farms[J].J Dairy Sci,2017,100(6):4797-4806.
[16]	KLAAS I C,ZADOKS R N.An update on environmental mastitis:Challenging perceptions[J].Transbound Emerg Dis,2018,65(S1):166-185.
[17]	SOOPENG K,HARUN D,MAT-AMIN M,et al.Enhanced virgin coconut oil (EVCO) as natural postmilking teat germicide to control environmental mastitis pathogens[J].Int J Biostechnol Well Ind,2016,5(4):128-134.
[18]	PAUDYAL S,MELENDEZ P,MANRIQUEZ D,et al.Use of milk electrical conductivity for the differentiation of mastitis causing pathogens in Holstein cows[J].Animal,2019,14(3):588-596.
[19]	MOLINARI P C C,BLAGITZ M G,LIBERA A M M P D,et al.Intracellular reactive oxygen species production and phagocytosis of Staphylococcus aureus by milk neutrophils as tool to diagnose mastitis and identify susceptible dairy cows[J].Pesq Vet Bras,2018,38(4):659-664.
[20]	RAINARD P,FOUCRAS G,BOICHARD D,et al.Invited review:Low milk somatic cell count and susceptibility to mastitis[J].J Dairy Sci,2018,101(8):6703-6714.
[21]	GREEN M,GREEN L,CRIPPS P.Low bulk milk SCC and toxic mastitis[J].Vet Rec,1996,138(18):452.
[22]	GOLI M,EZZATPANAH H,GHAVAMI M,et al.The effect of multiplex-PCR-assessed major pathogens causing subclinical mastitis on somatic cell profiles[J].Trop Anim Health Product,2012,44(7):1673-1680.
[23]	WANG L J,CHEN Y,LIU W H,et al.Changes of cytokines in serum and whey of dairy cows with subclinical mastitis[J].J Northeast Agr Univ:English Ed,2020,27(3):65-71.
[24]	CHARJAN-KU P Y,MANGLE N S,KALOREY D R,et al.Changes in milk pH and the levels of Na and K in whey associated with udder health status of cow[J].Indian Vet J,2000,77(12):1066-1068.
[25]	SARDARE S S,GUBBAWAR S G,DHURVE N G,et al.Quality assessment of cow milk affected by subclinical mastitis[J].Pharma Innov J,2017,6(11):75-77.
[26]	SUNDEKILDE U K,POULSEN N A,LARSEN L B,et al.Nuclear magnetic resonance metabonomics reveals strong association between milk metabolites and somatic cell count in bovine milk[J].J Dairy Sci,2013,96(1):290-299.
[27]	THOMAS F C,MUDALIAR M,TASSI R,et al.Mastitomics,the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis:3.Untargeted metabolomics[J].Mol BioSyst,2016,12(9):2762-2769.
[28]	DERVISHI E,ZHANG G S,DUNN S M,et al.GC-MS metabolomics identifies metabolite alterations that precede subclinical mastitis in the blood of transition dairy cows[J].J Proteome Res,2017,16(2):433-446.
[29]	DONNET-HUGHES A,PEREZ P F,DORÉ J,et al.Potential role of the intestinal microbiota of the mother in neonatal immune education[J].Proc Nutr Soc,2010,69(3):407-415.
[30]	YOUNG W,HINE B C,WALLACE O A M,et al.Transfer of intestinal bacterial components to mammary secretions in the cow[J].PeerJ,2015,3:e888.
[31]	RODRÍGUEZ J M.The origin of human milk bacteria:is there a bacterial entero-mammary pathway during late pregnancy and lactation?[J].Adv Nutr,2014,5(6):779-784.
[32]	ZHONG Y F,XUE M Y,LIU J X.Composition of rumen bacterial community in dairy cows with different levels of somatic cell counts[J].Front Microbiol,2018,9:3217-3227.
[33]	FENG Z P,XIN H Y,ZHANG Z W,et al.Gut microbiota homeostasis restoration may become a novel therapy for breast cancer[J].Investigat New Drugs,2021,39(3):871-878.
[34]	YANG J Q,TAN Q W,FU Q Y,et al.Gastrointestinal microbiome and breast cancer:correlations,mechanisms and potential clinical implications[J].Breast Cancer,2017,24(2):220-228.
[35]	GUNTER M J,XIE X H,XUE X N,et al.Breast cancer risk in metabolically healthy but overweight postmenopausal women[J].Cancer Res,2015,75(2):270-274.
[36]	MARGOLIS K L,RODABOUGH R J,THOMSON C A,et al.Prospective study of leukocyte count as a predictor of incident breast,colorectal,endometrial,and lung cancer and mortality in postmenopausal women[J].Arch Intern Med,2007,167(17):1837-1844.
[37]	CLARKE T B,DAVIS K M,LYSENKO E S,et al.Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity[J].Nat Med,2010,16(2):228-231.
[38]	HIEKEN T J,CHEN J,HOSKIN T L,et al.The microbiome of aseptically collected human breast tissue in benign and malignant disease[J].Sci Rep,2016,6:30751.
[39]	JIMÉNEZ E,FERNÁNDEZ L,MALDONADO A,et al.Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation[J].Appl Environ Microb,2008,74(15):4650-4655.
[40]	SWALES K E,KORBONITS M,CARPENTER R,et al.The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression[J].Cancer Res,2006,66(20):10120-10126.
[41]	CASTELLÓ A,POLLÁN M,BUIJSSE B,et al.Spanish mediterranean diet and other dietary patterns and breast cancer risk:case-control EpiGEICAM study[J].British J Cancer,2014,111(7):1454-1462.
[42]	ASCHENBACH J R,PENNER G B,STUMPFF F,et al.Ruminant nutrition symposium:role of fermentation acid absorption in the regulation of ruminal pH[J].J Anim Sci,2011,89(4):1092-1107.
[43]	刘小倩,刘颖,荣超,等.ACE2在奶牛乳腺中的表达定位及其抗炎性损伤作用的研究[J].畜牧兽医学报,2017,48(3):552-560.LIU X Q,LIU Y,RONG C,et al.Expression localization of angiotensin converting enzyme 2(ACE 2) in dairy cow mammary gland and its anti-inflammation effect[J].Acta Veterinaria et Zootechnica Sinica,2017,48(3):552-560.(in Chinese)
[44]	BOLLRATH J,POWRIE F.Immunology.Feed your tregs more fiber[J].Science,2013,341(6145):463-464.
[45]	FURUSAWA Y,OBATA Y,FUKUDA S,et al.Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells[J].Nature,2013,504(7480):446-450.
[46]	HU X Y,GUO J,ZHAO C J,et al.The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice[J].ISME J,2020,14(7):1897-1910.
[47]	CIARLO E,HEINONEN T,HERDERSCHEE J,et al.Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo[J].Sci Rep,2016,6(1):37944.
[48]	LASITSCHKA F,GIESE T,PAPARELLA M,et al.Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate.[J].Immun Inflamm Dis,2017,5(4):480-492.
[49]	WANG J J,WEI Z K,ZHANG X,et al.Propionate protects against lipopolysaccharide-induced mastitis in mice by restoring blood-milk barrier disruption and suppressing inflammatory response[J].Front Immunol,2017,8:1108.
[50]	WANG J J,WEI Z K,ZHANG X W,et al.Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide[J].Brit J Pharmacol,2017,174(21):3811-3822.
[51]	KIM M,QIE Y Q,PARK J,et al.Gut microbial metabolites fuel host antibody responses[J].Cell Host Microbe,2016,20(2):202-214.
[52]	EVEN S.Mastitis prevention with mammary probiotics[J].Dairy Global,2017,3(2):20-21.
[53]	DE LEBLANC A D M,MATAR C,LEBLANC N,et al.Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model[J].Breast Cancer Res,2005,7(4):R477-R486.
[54]	SANDERS M E,BENSON A,LEBEER S,et al.Shared mechanisms among probiotic taxa:implications for general probiotic claims[J].Curr Opin Biotechnol,2018,49:207-216.
[55]	OHLAND C L,MACNAUGHTON W K.Probiotic bacteria and intestinal epithelial barrier function[J].Am J Physiol Gastronintest Liver Physiol,2010,298(6):G807-G819.
[56]	KLAENHAMMER T R,KLEEREBEZEM M,KOPP M V,et al.The impact of probiotics and prebiotics on the immune system[J].Nat Rev Immunol,2012,12(10):728-734.
[57]	FUKUDA S,TOH H,HASE K,et al.Bifidobacteria can protect from enteropathogenic infection through production of acetate[J].Nature,2011,469(7331):543-547.
[58]	PORCHERIE A,GILBERT F B,GERMON P,et al.IL-17A is an important effector of the immune response of the mammary gland to Escherichia coli infection[J].J Immunol,2015,196(2):803-812.
[59]	SORINI C,CARDOSO R F,GAGLIANI N,et al.Commensal bacteria-specific CD4+ T Cell responses in health and disease[J].Front Immunol,2018,9:2667.
[60]	YIU J H C,DORWEILER B,WOO C W.Interaction between gut microbiota and toll-like receptor:from immunity to metabolism[J].J Mol Med (Berl),2017,95(1):13-20.
[61]	NAIK S,BOULADOUX N,WILHELM C,et al.Compartmentalized control of skin immunity by resident commensals[J].Science,2012,337(6098):1115-1119.

Research Progress on the Correlation between Gastrointestinal Microbiota and Bovine Mastitis in Dairy Cows and Its Regulatory Potential for Mastitis

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