氨气影响动物健康和生产性能的机理

doi:10.11843/j.issn.0366-6964.2021.02.004

Abstract

Abstract: The breeding environment is gradually deteriorating with the increase in the number and scale of livestock and poultry breeding. Since livestock and poultry are extremely sensitive to the air quality, the air quality is directly related to animal morbidity. Ammonia (NH₃) is one of the most harmful pollution sources in animal production. If the animal continuously exposed environment of ammonia, it will induce respiratory system diseases, cause neurological dysfunction, reduce the ability of reproduction and growth. Here we summarized the mechanism by which ammonia effects animal health and production performance.

Key words: ammonia, respiratory system, nervous system, reproductive performance, growth performance

CLC Number:

S852.2

CUI Jia, YANG Xinyu, LI Nan, CHEN Baojiang. Mechanism of Ammonia Affecting Animal Health and Productive Performance[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(2): 311-321.

References 117

[1]	YE H,XIAO S J,WANG X Q,et al.Characterization of spleen transcriptome of Schizothorax prenanti during Aeromonas hydrophila infection[J].Mar Biotechnol (NY),2018,20(2):246-256.
[2]	NIMMERMARK S,LUND V,GUSTAFSSON G,et al.Ammonia,dust and bacteria in welfare-oriented systems for laying hens[J].Ann Agric Environ Med,2009,16(1):103-113.
[3]	BURTON D J.Using the NIOSH pocket guide to chemical hazards[J].Occup Health Saf,2001,70(4):20,22.
[4]	VAN DER HEYDEN C,DEMEYER P,VOLCKE E I P.Mitigating emissions from pig and poultry housing facilities through air scrubbers and biofilters:state-of-the-art and perspectives[J].Biosyst Eng,2015,134:74-93.
[5]	BAUER S E,TSIGARIDIS K,MILLER R.Significant atmospheric aerosol pollution caused by world food cultivation[J].Geophys Res Lett,2016,43(10):5394-5400.
[6]	BEKER A,VANHOOSER S L,SWARTZLANDER J H,et al.Atmospheric ammonia concentration effects on broiler growth and performance[J].J Appl Poultry Res,2004,13(1):5-9,doi:10.1093/japr/13.1.5.
[7]	REEB-WHITAKER C K,PAIGEN B,BEAMER W G,et al.The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages[J].Lab Anim,2001,35(1):58-73,doi:10.1258/0023677011911381.
[8]	郭艳,张进良,李小平,等.不同质量浓度氨气对肉鸡生长性能和免疫功能的影响[J].河南师范大学学报:自然科学版,2020,48(5):93-98.GUO Y,ZHANG J L,LI X P,et al.Effects of different concentrations of ammonia on growth performance and immune function of broiler chickens[J].Journal of Henan Normal University:Natural Science Edition,2020,48(5):93-98.(in Chinese)
[9]	ZHANG J Z,LI C,TANG X F,et al.High concentrations of atmospheric ammonia induce alterations in the Hepatic Proteome of Broilers (Gallus gallus):an iTRAQ-based quantitative proteomic analysis[J].PLoS One,2015,10(4):e0123596, doi:10.1371/journal. pone. 0123596.
[10]	YI B,CHEN L,SA R N,et al.High concentrations of atmospheric ammonia induce alterations of gene expression in the breast muscle of broilers (Gallus gallus) based on RNA-Seq[J].BMC Genomics,2016,17:598,doi:10.1186/s12864-016-2961-2.
[11]	BRAUTBAR N,WU M P,RICHTER E D.Chronic ammonia inhalation and interstitial pulmonary fibrosis:a case report and review of the literature[J].Arch Environ Health:Int J,2003,58(9):592-596,doi:10.3200/AEOH.58.9.592-596.
[12]	GEORGE A,BANG R L,LARI A R,et al.Liquid ammonia injury[J].Burns,2000,26(4):409-413, doi:10.1016/s0305-4179(99)00141-2.
[13]	ZHANG J Z,LI C,TANG X F,et al.Proteome changes in the small intestinal mucosa of broilers (Gallus gallus) induced by high concentrations of atmospheric ammonia[J].Proteome Sci,2015,13:9.
[14]	JONES J B,WATHES C M,PERSAUD K C,et al.Acute and chronic exposure to ammonia and olfactory acuity for n-butanol in the pig[J].Appl Anim Behav Sci,2001,71(1):13-28,doi:10.1016/s0168-1591(00)00168-4.
[15]	WANG T X,HE Q Y,YAO W L,et al.The variation of nasal microbiota caused by low levels of gaseous ammonia exposure in growing pigs[J].Front Microbiol,2019,10:1083,doi:10.3389/fmicb.2019.01083.
[16]	PERKINS M W,WONG B,TRESSLER J,et al.Adverse respiratory effects in rats following inhalation exposure to ammonia:respiratory dynamics and histopathology[J].Inhal Toxicol,2017,29(1):32-41,doi:10.1080/08958378.2016.1277571.
[17]	PHILLIPS C J C,PINES M K,LATTER M,et al.The physiological and behavioral responses of steers to gaseous ammonia in simulated long-distance transport by ship[J].J Anim Sci,2010,88(11):3579-3589,doi:10.2527/jas.2010-3089.
[18]	Toxicological profile for ammonia[R].Atlanta:Agency for Toxic Substances and Disease Registry (ATSDR),2004:2-6.
[19]	GEISER T.Idiopathic pulmonary fibrosisa disorder of alveolar wound repair?[J].Swiss Med Wkly,2003,133(29-30):405-411.
[20]	HIGASHIYAMA H,YOSHIMOTO D,OKAMOTO Y,et al.Receptor-activated Smad localisation in bleomycin-induced pulmonary fibrosis[J].J Clin Pathol,2007,60(3):283-289,doi:10.1136/jcp.2006.037606.
[21]	LINDELL K O,JACOBS S S.Idiopathic pulmonary fibrosis[J].Am J Nurs,2003,103(4):32-42.
[22]	ZHOU Y, LIU Q X, LI X M, et al.Effects of ammonia exposure on growth performance and cytokines in the serum, trachea, and ileum of broilers. Poult Sci, 2020, 99(5):2485-2493.
[23]	DONE S H, CHENNELLS D J, GRESHAM A C J, et al. Clinical and pathological responses of weaned pigs to atmospheric ammonia and dust[J]. Vet Rec, 2005, 157(3):71-80.
[24]	KIM W K,PATTERSON P H.Effect of minerals on activity of microbial uricase to reduce ammonia volatilization in poultry manure[J].Poult Sci,2003,82(2):223-231.
[25]	WANG D X,ZHANG Y M,CHI Q R,et al.Ammonia exposure induced abnormal expression of cytokines and heat shock proteins via glucose metabolism disorders in chicken neutrophils[J].Environ Sci Pollut Res,2019,26(11):10529-10536.
[26]	BRAISSANT O,MCLIN V A,CUDALBU C.Ammonia toxicity to the brain[J].J Inherit Metab Dis,2013,36(4):595-612, doi:10.1007/s10545-012-9546-2.
[27]	ROYES L F F,GABBI P,RIBEIRO L R,et al.A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability[J].Amino Acids,2016,48(6):1373-1389.
[28]	SHI Q X,WANG W,CHEN M H,et al.Ammonia induces Treg/Th1 imbalance with triggered NF-κB pathway leading to chicken respiratory inflammation response[J].Sci Total Environ,2019,659:354-362,doi:10.1016/j.scitotenv.2018.12.375.
[29]	SINGLETON K D,SERKOVA N,BECKEY V E,et al.Glutamine attenuates lung injury and improves survival after sepsis:role of enhanced heat shock protein expression[J].Crit Care Med,2005,33(6):1206-1213,doi:10.1097/01.ccm.0000166357.10996.8a.
[30]	VEITH A C,BOU ARAM B,JIANG W W,et al.Mice lacking the cytochrome P4501B1 gene are less susceptible to hyperoxic lung injury than wild type[J].Toxicol Sci,2018,165(2):462-474,doi:10.1093/toxsci/kfy154.
[31]	YAN M L,PAMP S J,FUKUYAMA J,et al.Nasal microenvironments and interspecific interactions influence nasal microbiota complexity and S.aureus carriage[J].Cell Host Microbe,2013,14(6):631-640,doi:10.1016/j.chom.2013.11.005.
[32]	ZEINELDIN M M,LOWE J F,GRIMMER E D,et al.Relationship between nasopharyngeal and bronchoalveolar microbial communities in clinically healthy feedlot cattle[J].BMC Microbiol,2017,17:138,doi:10.1186/s12866-017-1042-2.
[33]	KORTEN I,RAMSEY K,MIKA M,et al.Nasal microbiota and respiratory tract infections:the role of viral detection[J].Am J Respir Crit Care Med,2019,199(7):919-922,doi:10.1164/rccm.201710-2020LE.
[34]	LANASPA M,BASSAT Q,MEDEIROS M M,et al.Respiratory microbiota and lower respiratory tract disease[J].Expert Rev Anti Infect Ther,2017,15(7):703-711,doi:10.1080/14787210.2017.1349609.
[35]	HAMILTON T D C,ROE J M,HAYES C M,et al.Effects of ammonia inhalation and acetic acid pretreatment on colonization kinetics of toxigenic Pasteurella multocida within upper respiratory tracts of swine[J].J Clin Microbiol,1998,36(5):1260-1265.
[36]	MALISELO P S,NKONDE G K.Ammonia production in poultry houses and its effect on the growth of Gallus Gallus Domestica (broiler chickens):a case study of a small scale poultry house in riverside,Kitwe,Zambia[J].Int J Sci Technol Res,2015,4(4):141-145.
[37]	RⅡSE G C,QVARFORDT I,LARSSON S,et al.Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro[J].Respiration,2000,67(5):552-558.
[38]	GUTBIER B,FISCHER K,DOEHN J M,et al.Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure[J].Am J Physiol Lung Cell Mol Physiol,2015,309(3):L250-L261,doi:10.1152/ajplung.00265.2014.
[39]	夏红玉.急性氨气中毒46例的救治与护理[J].吉林医学,2007,28(2):251.XIA H Y.The treatment and nursing of 46 cases of acute ammonia poisoning[J].Jilin Medicine,2007,28(2):251.(in Chinese)
[40]	ONG J P,AGGARWAL A,KRIEGER D,et al.Correlation between ammonia levels and the severity of hepatic encephalopathy[J].Am J Med,2003,114(3):188-193,doi:10.1016/s0002-9343(02)01477-8.
[41]	NORENBERG M D,RAMA RAO K V,JAYAKUMAR A R.Ammonia neurotoxicity and the mitochondrial permeability transition[J].J Bioenerg Biomembr,2004,36(4):303-307,doi:10.1023/B:JOBB.0000041758.20071.19.
[42]	RAMA RAO K V,JAYAKUMAR A R,NORENBERG D M.Ammonia neurotoxicity:role of the mitochondrial permeability transition[J].Metab Brain Dis,2003,18(2):113-127,doi:10.1023/a:1023858902184.
[43]	SKOWROŃSKA M,ALBRECHT J.Oxidative and nitrosative stress in ammonia neurotoxicity[J].Neurochem Int,2013,62(5):731-737,doi:10.1016/j.neuint.2012.10.013.
[44]	哈斯苏荣,杜小燕,蒋金书.复方丁氨丙磷溶液对肉仔鸡生产性能和血液生理生化指标的影响[J].中国兽医杂志,2004,40(5):12-14.HASI S R,DU X Y,JIANG J S.Effect of compound butaphopan on performance and blood biochemical parmeters of broilers[J].Chinese Journal of Veterinary Medicine,2004,40(5):12-14.(in Chinese)
[45]	张福.氨气对大鼠胸主动脉血管和心脏NO/cGMP信号通路等的影响[D].太原:山西大学,2017.ZHANG F.Effects of ammonia on NO/cGMP passway in rat vessel and heart[D].Taiyuan:Shanxi University,2017.(in Chinese)
[46]	ALVAREZ V M,RAMA RAO K V,BRAHMBHATT M,et al.Interaction between cytokines and ammonia in the mitochondrial permeability transition in cultured astrocytes[J].Neurosci Res,2011,89(12):2028-2040,doi:10.1002/jnr.22708.
[47]	MALIK S G,IRWANTO K A,OSTROW J D,et al.Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver[J].BMC Res Notes,2010,3:162,doi:10.1186/1756-0500-3-162.
[48]	NAKHOUL N L,ABDULNOUR-NAKHOUL S M,BOULPAEP E L,et al.Substrate specificity of Rhbg:ammonium and methyl ammonium transport[J].Am J Physiol Cell Physiol,2010,299(3):C695-C705,doi:10.1152/ajpcell.00019.2010.
[49]	COOPER A J,MCDONALD J M,GELBARD A S,et al.The metabolic fate of13N-labeled ammonia in rat brain[J].J Biol Chem,1979,254(12):4982-4992.
[50]	JAYAKUMAR A R,LIU M L,MORIYAMA M,et al.Na-K-Cl Cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling[J]. J Biol Chem,2008,283(49):33874-33882,doi:10.1074/jbc.M804016200.
[51]	RANGROO THRANE V,THRANE A S,CHANG J,et al.Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy[J].Neuroscience,2012,220:247-255,doi:10.1016/j.neuroscience.2012.06.022.
[52]	RAMA RAO K V,VERKMAN A S,CURTIS K M,et al.Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure[J].Neurobiol Dis,2014,63:222-228,doi:10.1016/j.nbd.2013.11.018.
[53]	BUTTERWORTH R F.Pathophysiology of brain dysfunction in hyperammonemic syndromes:the many faces of glutamine[J].Mol Genet Metab,2014,113(1-2):113-117,doi:10.1016/j.ymgme.2014.06.003.
[54]	OTT P,CLEMMESEN O,LARSEN F S.Cerebral metabolic disturbances in the brain during acute liver failure:from hyperammonemia to energy failure and proteolysis[J].Neurochem Int,2005,47(1-2):13-18,doi:10.1016/j.neuint.2005.04.002.
[55]	RAMA RAO K V,NORENBERG M D.Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy[J].Neurochem Int,2012,60(7):697-706,doi:10.1016/j.neuint.2011.09.007.
[56]	仲月霞,曹义战,王伯良,等.急性氨气中毒16例的救治分析[J].西南国防医药,2003,13(6):623-625.ZHONG Y X,CAO Y Z,WANG B L,et al.Experience in rescuing patients with acute ammonia poisoning:report of 16 cases[J].Medical Journal of National Defending Forces in Southwest China,2003,13(6):623-625.(in Chinese)
[57]	ALBRECHT J,NORENBERG M D.Glutamine:a Trojan horse in ammonia neurotoxicity[J].Hepatology,2006,44(4):788-794.
[58]	BOSOI C R,ZWINGMANN C,MARIN H,et al.Increased brain lactate is central to the development of brain edema in rats with chronic liver disease[J].J Hepatol,2014,60(3):554-560,doi:10.1016/j.jhep.2013.10.011.
[59]	MARTINEZ-HERNANDEZ A,BELL K P,NORENBERG M D.Glutamine synthetase:glial localization in brain[J].Science,1977,195(4284):1356-1358.
[60]	DAM G,KEIDING S,MUNK O L,et al.Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow,not increased ammonia uptake[J].Hepatology,2013,57(1):258-265,doi:10.1002/hep.25995.
[61]	李夏青,韩德五,赵元昌.氨对脑细胞胞浆游离钙含量的影响[J].中国应用生理学杂志,2000,16(2):114-116.LI X Q,HAN D W,ZHAO Y C.The effect of ammonia on the free calcium content of isolated brain cells[J].Chinese Journal of Applied Physiology,2000,16(2):114-116.(in Chinese)
[62]	BEHERA S N,SHARMA M,ANEJA V P,et al.Ammonia in the atmosphere:a review on emission sources,atmospheric chemistry and deposition on terrestrial bodies[J].Environ Sci Pollut Res,2013,20(11):8092-8131,doi:10.1007/s11356-013-2051-9.
[63]	DENG Z B,CHEN F,ZHANG M X,et al.Association between air pollution and sperm quality:a systematic review and meta-analysis[J].Environ Pollut,2016,208:663-669,doi:10.1016/j.envpol.2015.10.044.
[64]	CAI L S,KOZIEL J A,LO Y C,et al.Characterization of volatile organic compounds and odorants associated with swine barn particulate matter using solid-phase microextraction and gas chromatography-mass spectrometry-olfactometry[J].J Chromatogr A,2006,1102(1-2):60-72,doi:10.1016/j.chroma.2005.10.040.
[65]	郝二英,陈辉,赵宇,等.不同浓度氨气对蛋鸡生产性能、蛋品质的影响[J].中国家禽,2015,37(19):36-39.HAO E Y,CHEN H,ZHAO Y,et al.Effect of different concentrations of ammonia on the production performance and egg quality of laying hens[J].China Poultry,2015,37(19):36-39.(in Chinese)
[66]	布仁,红华.环境因子对蛋鸡生产性能的影响[J].家畜生态,2001,22(2):40-43.BU R,HONG H.Study on the effect of environmental factors on the productivity in layers[J].Ecology of Domestic Animal,2001,22(2):40-43.(in Chinese)
[67]	AMER A H,PINGEL H,HILLIG J,et al.Impact of atmospheric ammonia on laying performance and egg shell strength of hens housed in climatic chambers[J].Archiv Fur Geflugelkunde,2004,68(3):120-125.
[68]	KILIC I, YASLIOGLU E. Ammonia and carbon dioxide concentrations in a layer house. Asian-Australas J Anim Sci, 2014, 27(8):1211-1218.
[69]	李振.鸡舍有害气体的来源、危害及调控[J].兽医导刊,2007(2):41-42.LI Z.Sources,hazards and control of harmful gases in chicken houses[J].Veterinary Guide,2007(2):41-42.(in Chinese)
[70]	CHARLES D R,PAYNE C G.The influence of graded levels of atmospheric ammonia on chickens.I.Effects on respiration and on the performance of broilers and replacement growing stock[J].Br Poult Sci,1966,7(3):177-187,doi:10.1080/00071668608415622.
[71]	徐磊,高杰,张道华,等.不同氨气浓度饲养环境对大小鼠繁育生长性能的影响研究[J].医学动物防制,2016,32(2):183-186.XU L,GAO J,ZHANG D H,et al.The effects of ammonia concentration on the breeding of mice and rats[J].Journal of Medical Pest Control,2016,32(2):183-186.(in Chinese)
[72]	CAMBRA-LÓPEZ M,AARNINK A J A,ZHAO Y,et al.Airborne particulate matter from livestock production systems:a review of an air pollution problem[J].Environ Pollut,2010,158(1):1-17,doi:10.1016/j.envpol.2009.07.011.
[73]	谈立峰, 孙雪照, 李燕南, 等. 甲萘威农药生产职业暴露对男工精子和精液质量的影响[J].中华劳动卫生职业病杂志, 2005, 23(2):87-90.TAN L F, SUN X Z, LI Y N, et al. Effects of carbaryl production exposure on the sperm and semen quality of occupational male workers[J]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2005, 23(2):87-90. (in Chinese)
[74]	ZHANG W, ZHAO Y, ZHANG P, et al. Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable[J]. Chemosphere, 2018, 194:147-157.
[75]	BIRDSALL M A,PEEK J,VALIAPAN S.Sperm quality in New Zealand:is the downward trend continuing?[J].N Z Med J,2015,128(1423):50-56.
[76]	FATHI NAJAFI T,LATIFNEJAD ROUDSARI R,NAMVAR F,et al.Air pollution and quality of sperm:a meta-analysis[J].Iran Red Crescent Med J,2015,17(4):e26930,doi:10.5812/ircmj.17(4)2015.26930.
[77]	HAMMOUD A,CARRELL D T,GIBSON M,et al.Decreased sperm motility is associated with air pollution in Salt Lake City[J].Fertil Steril,2010,93(6):1875-1879,doi:10.1016/j.fertnstert.2008.12.089.
[78]	JÓŹWIK M,JÓŹWIK M,WOŁCZYŃSKI S,et al.Ammonia concentration in human preovulatory ovarian follicles[J].Eur J Obstet Gynecol Reprod Biol,2001,94(2):256-260,doi:10.1016/s0301-2115(00)00320-1.
[79]	HAMMON D S,HOLYOAK G R,DHIMAN T R.Association between blood plasma urea nitrogen levels and reproductive fluid urea nitrogen and ammonia concentrations in early lactation dairy cows[J].Anim Reprod Sci,2005,86(3-4):195-204.
[80]	PENTIKÄINEN V,SUOMALAINEN L,ERKKILÄ K,et al.Nuclear factor-κB activation in human testicular apoptosis[J].Am J Pathol,2002,160(1):205-218,doi:10.1016/s0002-9440(10)64364-7.
[81]	YANG L L,ZHAO Y,LUO S M,et al.Toxic effects and possible mechanisms of hydrogen sulfide and/or ammonia on porcine oocyte maturation in vitro[J].Toxicol Lett,2018,285:20-26,doi:10.1016/j.toxlet.2017.12.019.
[82]	HINE C,HARPUTLUGIL E,ZHANG Y,et al.Endogenous hydrogen sulfide production is essential for dietary restriction benefits[J].Cell,2015,160(1-2):132-144,doi:10.1016/j.cell.2014.11.048.
[83]	NOWIK M,KAMPIK N B,MIHAILOVA M,et al.Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and ratsspecies differences and technical considerations[J].Cell Physiol Biochem,2010,26(6):1059-1072,doi:10.1159/000323984.
[84]	CENTOLA G M,BLANCHARD A,DEMICK J,et al.Decline in sperm count and motility in young adult men from 2003 to 2013:observations from a U.S.sperm bank[J].Andrology,2016,4(2):270-276,doi:10.1111/andr.12149.
[85]	YUAN L,LIU J G,ZHAO J,et al.The murine SCP3 gene is required for synaptonemal complex assembly,chromosome synapsis,and male fertility[J].Mol Cell,2000,5(1):73-83,doi:10.1016/s1097-2765(00)80404-9.
[86]	WEI F X,HU X F,XU B,et al.Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers[J].Genet Mol Res,2015,14(2):3160-3169,doi:10.4238/2015.April.10.27.
[87]	XIONG Y,TANG X F,MENG Q S,et al.Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS[J].Sci China Life Sci,2016,59(11):1166-1176,doi:10.1007/s11427-016-0202-8.
[88]	SOLIMAN E S,MOAWED S A,HASSAN R A.Influence of microclimatic ammonia levels on productive performance of different broilers' breeds estimated with univariate and multivariate approaches[J].Vet World,2017,10(8):880-887.
[89]	YAHAV S.Ammonia affects performance and thermoregulation of male broiler chickens[J].Anim Res,2004,53(4):289-293.
[90]	MILES D M,BRANTON S L,LOTT B D.Atmospheric ammonia is detrimental to the performance of modern commercial broilers[J].Poult Sci,2004,83(10):1650-1654,doi:10.1093/ps/83.10.1650.
[91]	DONG X, LIU Q, KAN D, et al.Effects of ammonia-N exposure on the growth, metabolizing enzymes, and metabolome of Macrobrachium rosenbergii[J]. Ecotoxicol Environ Saf. 2020 Feb;189:110046, doi:10.1016/j.ecoenv.2019.110046.Epub 2019 Dec 10.PMID:31835043.
[92]	HARRIS A N, LEE H W, OSIS G, et al.Differences in renal ammonia metabolism in male and female kidney[J]. Am J Physiol Renal Physiol, 2018, 315(2):F211-F222.
[93]	SA R N,XING H,LUAN S J,et al.Atmospheric ammonia alters lipid metabolism-related genes in the livers of broilers (Gallus gallus)[J].J Anim Physiol Anim Nutr (Berl),2018,102(2):e941-e947,doi:10.1111/jpn.12859.
[94]	TAO Z Y,XU W J,ZHU C H,et al.Effects of ammonia on intestinal microflora and productive performance of laying ducks[J].Poult Sci,2019,98(5):1947-1959,doi:10.3382/ps/pey578.
[95]	阿卜杜热合曼·达尼亚尔.不同氨气浓度对黄麻羽肉鸡生产及抗氧化性能、血氨及尿酸的影响[D].石河子:石河子大学,2018.ABUDUREHEMAN D.Effects of different ammonia concentration on the production and antioxidant properties,blood ammonia and uric acid of jute feather broiler[D].Shihezi:Shihezi University,2018.(in Chinese)
[96]	李东卫,卢庆萍,白水莉,等.模拟条件下鸡舍氨气浓度对肉鸡生长性能和日常行为的影响[J].动物营养学报,2012,24(2):322-326.LI D W,LU Q P,BAI S L,et al.Effects of ammonia concentration in poultry house on growth performance and conventional behavior of broilers under simulated conditions[J].Chinese Journal of Animal Nutrition,2012,24(2):322-326.(in Chinese)
[97]	刘明.不同氨气浓度对肉牛生长性能以及生理生化指标的影响[D].杨凌:西北农林科技大学,2019.LIU M.Effects of different NH3 concentration on growth performance,physiological and biochemical indexes of cattle[D].Yangling:Northwest A&F University,2019.(in Chinese)
[98]	曹进,张峥.封闭猪场内氨气对猪群生产性能的影响及控制试验[J].养猪,2003(4):42-44.CAO J,ZHANG Z.The effect of ammonia gas on the performance of pig herd and its control experiment in closed pig farm[J].Swine Production,2003(4):42-44.(in Chinese)
[99]	CHEN D C,MIAO Z Y,PENG M Q,et al.The co-expression of circRNA and mRNA in the thymuses of chickens exposed to ammonia[J].Ecotoxicol Environ Saf,2019,176:146-152,doi:10.1016/j.ecoenv.2019.03.076.
[100]	LIANG L X,AI L Y,QIAN J,et al.Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes[J].Sci Rep,2015,5:11763,doi:10.1038/srep11763.
[101]	MOUSAVI S E,AMINI H,HEYDARPOUR P,et al.Air pollution,environmental chemicals,and smoking may trigger vitamin D deficiency:evidence and potential mechanisms[J].Environ Int,2019,122:67-90,doi:10.1016/j.envint.2018.11.052.
[102]	DE PAULA RIBEIRO J,KALB A C,CAMPOS P P,et al.Toxicological effects of particulate matter (PM2.5) on rats:bioaccumulation,antioxidant alterations,lipid damage,and ABC transporter activity[J].Chemosphere,2016,163:569-577,doi:10.1016/j.chemosphere.2016.07.094.
[103]	MURTHY C R K,BENDER A S,DOMBRO R S,et al.Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes[J].Neurochem Int,2000,37(2-3):255-268,doi:10.1016/s0197-0186(00)00028-0.
[104]	RAMA S,MANJABHAT S N.Protective effect of shrimp carotenoids against ammonia stress in common carp,Cyprinus carpio[J].Ecotoxicol Environ Saf,2014,107:207-213,doi:10.1016/j.ecoenv.2014.06.016.
[105]	DAI H L,SONG D,XU J N,et al.Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation,MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling[J].Neurochem Int,2013,63(6):610-625.
[106]	SINHA A K,ZINTA G,ABDELGAWAD H,et al.High environmental ammonia elicits differential oxidative stress and antioxidant responses in five different organs of a model estuarine teleost (Dicentrarchus labrax)[J].Comp Biochem Physiol C:Toxicol Pharmacol,2015,174-175:21-31,doi:10.1016/j.cbpc.2015.06.002.
[107]	SU Y F,CHEN Z F,YAN L L,et al.Optimizing combination of liver-enriched transcription factors and nuclear receptors simultaneously favors ammonia and drug metabolism in liver cells[J].Exp Cell Res,2018,362(2):504-514.
[108]	PU J N,TIAN G,LI B,et al.Trace mineral overload induced hepatic oxidative damage and apoptosis in pigs with long-term high-level dietary mineral exposure[J].J Agric Food Chem,2016,64(8):1841-1849.
[109]	SHAH S W A,CHEN J Q,HAN Q,et al.Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius:Implication of oxidative stress and apoptosis[J].Ecotoxicol Environ Saf,2020,190:1100788.
[110]	DYBDAHL M,RISOM L,MØLLER P,et al.DNA adduct formation and oxidative stress in colon and liver of Big Blue® rats after dietary exposure to diesel particles[J].Carcinogenesis,2003,24(11):1759-1766,doi:10.1093/carcin/bgg147.
[111]	ZHENG S F,JIN X,CHEN M H,et al.Hydrogen sulfide exposure induces jejunum injury via CYP450 s/ROS pathway in broilers[J].Chemosphere,2019,214:25-34,doi:10.1016/j.chemosphere.2018.09.002.
[112]	杨新宇,崔嘉,陈小风,等.应用Illumina-HiSeq高通量测序技术分析氨气对小鼠肠道菌群的影响[J].中国兽医学报,2019,39(5):948-955.YANG X Y,CUI J,CHEN X F,et al.Effects of ammonia on intestinal microbiota diversity of mice analyzed by Illumina-HiSeq high-throughput sequencing technology[J].Chinese Journal of Veterinary Science,2019,39(5):948-955.(in Chinese)
[113]	邢焕.舍内氨气对肉鸡脂肪代谢的影响[D].北京:中国农业科学院,2015.XING H.Effect of ammonia in houses on lipid metabolism of broilers[D].Beijing:Chinese Academy of Agricultural Sciences,2015.(in Chinese)
[114]	YI B,CHEN L,SA R N,et al.Transcriptome profile analysis of breast muscle tissues from high or low levels of atmospheric ammonia exposed broilers (Gallus gallus)[J].PLoS One,2016,11(9):e0162631.
[115]	TANG S, XIE J, WU W, et al.High ammonia exposure regulates lipid metabolism in the pig skeletal muscle via mTOR pathway[J]. Sci Total Environ, 2020, 740:139917.doi:10.1016/j.scitotenv.2020.139917.Epub 2020 Jun 3.PMID:32563870.
[116]	伊宝.基于RNA-Seq的舍内氨气对肉鸡胸肌生长发育的分子机制[D].北京:中国农业科学院,2017.YI B.The molecular mechanism of ammonia on growth and development of breast muscle in broilers based on RNA-Seq[D].Beijing:Chinese Academy of Agricultural Sciences,2017.(in Chinese)
[117]	姜庆林,王志国,徐文娟,等.舍内氨气浓度对鸭肝脏PPARα、FABP1及LPL基因表达的影响[J].扬州大学学报:农业与生命科学版,2019,40(6):82-85.JIANG Q L,WANG Z G,XU W J,et al.Effect of different ammonia concentration on the expression of PPARα,FABP1 and LPL genes in duck liver[J].Journal of Yangzhou University:Agricultural and Life Science Edition,2019,40(6):82-85.(in Chinese)

Mechanism of Ammonia Affecting Animal Health and Productive Performance

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 117

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	YU Zhou, YANG Baigao, ZHANG Hang, XU Xi, ZHANG Peipei, FENG Xiaoyi, CAO Jianhua, NIU Yifan, DU Weihua, HAO Haisheng, ZHU Huabin, ABULIZI·Wusiman, ZHAO Xueming. Research Progress of Estrus Markers in Dairy Buffalo [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3623-3630.
[2]	FU Xiyao, CHEN Lihong, CHEN Xiaoli, SUN Weili, GUO Xiaolan. Study on Dietary Crude Protein Level of 11-17 Weeks Old Female Pheasant [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2910-2923.
[3]	YANG Chulei, ZHANG Yiyuan, TANG Hong, GUO Yanhua, REN Xiumeiao, WANG Limin, ZHOU Ping. Research Progress of FecB Gene on Reproductive Performance of Sheep [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1370-1380.
[4]	WANG Mingli, WANG Meng, LI Yansen, XU Shanjin, HAN Guofeng, LI Chunmei. Effect of Different Crude Protein Levels of Artificial Crop Milk on Growth Performance,Serum Antioxidant Level and Intestinal Development of Squabs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1545-1554.
[5]	WANG Weihao, DUAN Yan, WANG Hongdi, DOU Lu, LIU Ting, KANG Letian, SUN Lina, AO Tehenggerile, JIN Ye. Effects of Feeding Regimens on Growth Performance, Slaughter Performance, Meat Quality and Rumen Bacteria Community of Sunit Sheep [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1085-1094.
[6]	YAN Qiongxian, CHEN Wenxun, HUI Haoyang, PENG Can, TANG Shaoxun, ZHOU Xiaoling, TAN Zhiliang. Effects of Zearalenone on Growth Performance, Gastrointestinal Fermentation and Microbiota Community Structure of Goats [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1109-1123.
[7]	SU Dan, WEN Xiaobin, MA Teng, ZHONG Ruqing, WANG Yang, CHEN Liang. Effects of Hydroxytyrosol on Growth Performance, Antioxidant Capacity and Intestinal Inflammatory Factors in Broilers [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4851-4859.
[8]	LIU Pan, LI Ruiqi, TAN Zhankun, WANG Yifei, CHEN Xiaochen, HE Weixian, DU Renrang, MA Jian, CHU Guiyan, CAI Chuanjiang. Effects of High Fiber Diet on Growth Performance, Meat Quality and Intestinal Microbiome of Growing-finishing Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4247-4259.
[9]	GUO Yanhong, TANG Jing, ZHANG Bo, CAO Junting, GUO Zhanbao, XIE Ming, ZHOU Zhengkui, WU Yongbao, WEN Zhiguo. Effects of Dietary Metabolizable Energy and Methionine Levels on Growth Performance, Carcass Characteristics, and Plasma Biochemical Parameters for Growing Pekin Ducks [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4278-4288.
[10]	CHANG Weichen, LI Shuaiqi, LI Yan, YAN Wei, ZHANG Hongying, WANG Yanbin, YANG Mingfan, ZHANG Angke. Effect of Pulsatilla Powder Prescription Decoction Ferments on Intestinal Barrier Function of Piglets Infected with Porcine Epidemic Diarrhea Virus [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4403-4410.
[11]	WANG Jian, CHEN Xueping, LI Jichang. Effects of Lactobacillus salivary on Growth Performance and Lung Injury of Broilers Challenged with Mycoplasma gallisepticum [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 3172-3179.
[12]	LU Jian, WANG Kehua, YANG Xiaodong, WANG Xingguo, LI Yongfeng, MA Meng, DOU Taocun, HU Yuping, GUO Jun, LI Shangmin, QU Liang. Effects of Dietary Metabolizable Energy Levels during Rearing on Growth and Development of Rugao Yellow Chicken at the Initiation of the Laying Period [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2215-2227.
[13]	CHE Dalu, CHENG Sucai, ZHANG Weitao, ZHAO Juanjuan, LIU Aiyu, LI Xiaoyu, ZHOU Yinghao, GAO Yuhong, SUN Xinsheng, LI Xuemei. Effects of Huopopuling Powder on Growth Performance, Digestibility and Serum Biochemical Indexes in Fattening Lambs under Heat Stress [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1829-1840.
[14]	GUO Zihan, JIANG Qiqi, WANG Bin, ZHAO Na, HE Zhifei, LI Hongjun, LV Jingzhi. Effect of Lighting Rhythm on Growth Performance, Serum Biochemical Indexes, Meat Quality and Welfare of Rabbits [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1500-1508.
[15]	HAN Pengmin, ZHANG Ran, BIAN Shixiong, LI Yunlei, NI Aixin, WANG Yuanmei, ZONG Yunhe, ZHAO Jinmeng, YUAN Jingwei, SUN Yanyan, LI Jianhui, CHEN Jilan, MA Hui. Effects of Enterococcus faecium and Bacillus subtilis on GrowthPerformance, Carcass Traits and Immune Function of Squabs [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3880-3891.