唾液乳杆菌对鸡毒支原体感染肉鸡生长性能及肺损伤的影响

doi:10.11843/j.issn.0366-6964.2022.09.031

Abstract

Abstract: The purpose of the present study was to evaluate the effects of Lactobacillus salivarius on growth performance and lung injury of broiler chickens challenged with Mycoplasma gallisepticum (MG). Total of 240 one-day-old broiler chickens were randomly distributed into 6 groups, including control group (Con), low dose Lactobacillus salivarius group (L), high dose Lactobacillus salivarius group (H), MG infection group (MG), MG infection+low dose Lactobacillus salivarius group (MG+L), MG infection+high dose Lactobacillus salivarius group (MG+H). Broilers in Con group and MG group were fed control diet during experiment period; broilers in L group and MG+L group were fed control diet supplemented with Lactobacillus salivarius of 10⁸ CFU·kg^-1 feed during experiment period; broilers in H group and MG+H group were fed control diet supplemented with Lactobacillus salivarius of 10⁹ CFU·kg^-1 feed during experiment period; broilers in MG, MG+L and MG+H group were challenged with MG at 1 week of age. The effects of Lactobacillus salivarius supplementation on the body weight, feed conversion ratio, lung histopathology change, pulmonary MG colonization, pulmonary inflammatory injury related proteins expression and pulmonary pro-inflammatory cytokines content were determined after 42 d of feeding. The results showed that the Lactobacillus salivarius supplementation could improve growth performance and feed conversion ratio of broilers challenged with MG (P<0.01). In addition, the Lactobacillus salivarius supplementation could promote MG clearance in lung and alleviate lung injury caused by MG which were characterized by the significant decreased TLR2, HMGB1, p-p65/p65, NLRP3, Pro-Caspase-1/Caspase-1 expression levels (P<0.01) and significant decreased TNF-α, IL-1β, IL-6, IL-8 contents (P<0.01). These results suggested a tremendous potential of Lactobacillus salivarius as a feed additive in the poultry feed to against MG infection.

Key words: Mycoplasma gallisepticum, Lactobacillus salivarius, growth performance, lung injury

CLC Number:

S856.3
S855

WANG Jian, CHEN Xueping, LI Jichang. Effects of Lactobacillus salivary on Growth Performance and Lung Injury of Broilers Challenged with Mycoplasma gallisepticum[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 3172-3179.

References 30

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Effects of Lactobacillus salivary on Growth Performance and Lung Injury of Broilers Challenged with Mycoplasma gallisepticum

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