脂肪酸调控奶牛乳腺microRNAs研究进展

doi:10.11843/j.issn.0366-6964.2020.12.003

Abstract

Abstract: Lipids are a kind of substance which can store and provide energy for animals. A large number of studies have confirmed that the change of lipids in diets can alter the expression of microRNAs (miRNAs) and thus affect the biological activities of the bodies. This review mainly summarizes the regulation of fatty acids on the expression of miRNAs in mammary gland of dairy cows, from the aspects of bovine mammary miRNAs expression characteristics, miRNAs that regulate milk fat synthesis, and the changed bovine mammary miRNAs in response to exogenous addition of fatty acids. All these works may be beneficial for the establishment of the connection between nutrients and mammary function, and provide information for the related research in the future.

Key words: dairy cow, fatty acids, mammary microRNAs, milk fat

CLC Number:

S823.91

CAI Meng, NAN Xuemei, XIONG Benhai, YANG Liang. Research Progress of Fatty Acid Regulation of microRNAs in Dairy Cow Mammary Glands[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(12): 2934-2941.

References 70

[1]	KROL J,LOEDIGE I,FILIPOWICZ W.The widespread regulation of microRNA biogenesis,function and decay[J].Nat Rev Genet,2010,11(9):597-610.
[2]	SENGUPTA D,CASSEL T,TENG K Y,et al.Regulation of hepatic glutamine metabolism by miR-122[J].Mol Metab,2020,34:174-186.
[3]	LI X H,JIANG P,YU H B,et al.miR-21-3p targets Elovl5 and regulates triglyceride production in mammary epithelial cells of cow[J].DNA Cell Biol,2019,38(4):352-357.
[4]	ZHANG X,WANG Y F,WANG M Z,et al.Arginine supply impacts the expression of candidate microRNA controlling milk casein yield in bovine mammary tissue[J].Animals,2020,10(5):797.
[5]	LI R,BEAUDOIN F,AMMAH A A,et al.Deep sequencing shows microRNA involvement in bovine mammary gland adaptation to diets supplemented with linseed oil or safflower oil[J].BMC Genomics,2015,16(1):884.
[6]	马占峰,刘洪芳.影响牛奶成分的因素[J].中国奶牛,2012(1):44-46.MA Z F,LIU H F.Factors affecting milk composition[J].China Dairy Cattle,2012(1):44-46.(in Chinese)
[7]	ESQUELA-KERSCHER A,SLACK F J.Oncomirs-microRNAs with a role in cancer[J].Nat Rev Cancer,2006,6(4):259-269.
[8]	CATALANOTTO C,COGONI C,ZARDO G.MicroRNA in control of gene expression:an overview of nuclear functions[J].Int J Mol Sci,2016,17(10):1712.
[9]	LIU C G,CALIN G A,MELOON B,et al.An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues[J].Proc Natl Acad Sci U S A,2004,101(26):9740-9744.
[10]	GU Z L,ELESWARAPU S,JIANG H L.Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland[J].FEBS Lett,2007,581(5):981-988.
[11]	WANG M,孙鹏.泌乳阶段对奶牛乳腺microRNA表达模式的影响[J].中国畜牧兽医,2012,39(11):93.WANG M,SUN P.Effect of lactation stage on microRNA expression pattern in mammary gland of dairy cows[J].China Animal Husbandry & Veterinary Medicine,2012,39(11):93.(in Chinese)
[12]	AVRIL-SASSEN S, GOLDSTEIN L D, STINGL J, et al. Characterisation of microRNA expression in post-natal mouse mammary gland development[J]. BMC Genomics, 2009,10:548.
[13]	LUORENG Z M,WANG X P,MEI C G,et al.Comparison of microRNA profiles between bovine mammary glands infected with Staphylococcus aureus and Escherichia coli[J].Int J Biol Sci,2018,14(1):87-99.
[14]	LI Q L,YANG C H,DU J,et al.Characterization of miRNA profiles in the mammary tissue of dairy cattle in response to heat stress[J].BMC Genomics,2018,19(1):975.
[15]	SALAMA A A K,DUQUE M,WANG L,et al.Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins,messenger RNA,and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro[J].J Dairy Sci,2019,102(3):2469-2480.
[16]	IZUMI H,TSUDA M,SATO Y,et al.Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages[J].J Dairy Sci,2015,98(5):2920-2933.
[17]	ZEMPLENI J,AGUILAR-LOZANO A,SADRI M,et al.Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants[J].J Nutr,2017,147(1):3-10.
[18]	YANG W C,GUO W L,ZAN L S,et al.Bta-miR-130a regulates the biosynthesis of bovine milk fat by targeting peroxisome proliferator-activated receptor gamma[J].J Anim Sci,2017,100(9):2898-2906.
[19]	ZHANG M Q,GAO J L,LIAO X D,et al.miR-454 regulates triglyceride synthesis in bovine mammary epithelial cells by targeting PPAR-γ[J].Gene,2019,691:1-7.
[20]	WANG M,MOISÁ S,KHAN M J,et al.MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation[J].J Dairy Sci,2012,95(11):6529-6535.
[21]	WANG J,BIAN Y J,WANG Z R,et al.MicroRNA-152 Regulates DNA methyltransferase 1 and is involved in the development and lactation of mammary glands in dairy cows[J].PLoS One,2014,9(7):e101358.
[22]	BIAN Y J,LEI Y,WANG C M,et al.Epigenetic regulation of miR-29s affects the lactation activity of dairy cow mammary epithelial cells[J].J Cell Physiol,2015,230(9):2152-2163.
[23]	LIAN S,GUO J R,NAN X M,et al.MicroRNA Bta-miR-181a regulates the biosynthesis of bovine milk fat by targeting ACSL1[J].J Dairy Sci,2016,99(5):3916-3924.
[24]	WANG Y J,GUO W L,TANG K Q,et al.Bta-miR-34b regulates milk fat biosynthesis by targeting mRNA decapping enzyme 1A (DCP1A) in cultured bovine mammary epithelial cells[J].J Anim Sci,2019,97(9):3823-3831.
[25]	CHEN Z,CHU S F,WANG X L,et al.MicroRNA-106b regulates milk fat metabolism via ATP binding cassette subfamily A member 1(ABCA1) in bovine mammary epithelial cells[J].J Agric Food Chem,2019,67(14):3981-3990.
[26]	SHEN B L,ZHANG L Y,LIAN C J,et al.Deep sequencing and screening of differentially expressed microRNAs related to milk fat metabolism in bovine primary mammary epithelial cells[J].Int J Mol Sci,2016,17(2):200.
[27]	辛雨.n-3多不饱和脂肪酸调节饮食诱导肥胖大鼠miRNA表达变化[D].青岛:青岛大学,2013.XIN Y.Identification of miRNA expression pattern induced by n-3 PUFA in obesity rats[D].Qingdao:Qingdao University,2013.(in Chinese)
[28]	VISIOLI F,GIORDANO E,NICOD N M,et al.Molecular targets of omega 3 and conjugated linoleic fatty acids-"Micromanaging" cellular response[J].Front Physiol,2012,3:42.
[29]	ZHENG Z,GE Y L,ZHANG J Y,et al.PUFA diets alter the microRNA expression profiles in an inflammation rat model[J].Mol Med Rep,2015,11(6):4149-4157.
[30]	DELGADO-LISTA J,PEREZ-MARTINEZ P,LOPEZ-MIRANDA J,et al.Long chain omega-3 fatty acids and cardiovascular disease:a systematic review[J].Brit J Nutr,2012,107(S2):S201-S213.
[31]	ASLAN C,MARALBASHI S,KAHROBA H,et al.Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs[J].Life Sci,2020,258:118094.
[32]	LEMAY-NEDJELSKI L,MASON-ENNIS J K,TAIBI A,et al.Omega-3 polyunsaturated fatty acids time-dependently reduce cell viability and oncogenic microRNA-21 expression in estrogen receptor-positive breast cancer cells (MCF-7)[J].Int J Mol Sci,2018,19(1):244.
[33]	CETRULLO S,D'ADAMO S,PANICHI V,et al.Modulation of fatty acid-related genes in the response of H9c2 cardiac cells to palmitate and n-3 polyunsaturated fatty acids[J].Cells,2020,9(3):537.
[34]	CHECHI K,NEDERGAARD J,RICHARD D.Brown adipose tissue as an anti-obesity tissue in humans[J].Obes Rev,2014,15(2):92-106.
[35]	MEALE S J,ROMAO J M,HE M L,et al.Effect of diet on microRNA expression in ovine subcutaneous and visceral adipose tissues[J].J Anim Sci,2014,92(8):3328-3337.
[36]	PAHLAVANI M,WIJAYATUNGA N N,KALUPAHANA N S,et al.Transcriptomic and microRNA analyses of gene networks regulated by eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice[J].Biochim Biophys Acta Mol Cell Biol Lipids,2018,1863(12):1523-1531.
[37]	GOUBRAN H A,KOTB R R,STAKIW J,et al.Regulation of tumor growth and metastasis:the role of tumor microenvironment[J].Cancer Growth Metastasis,2014,7:9-18.
[38]	GASPERI V,VANGAPANDU C,SAVINI I,et al.Polyunsaturated fatty acids modulate the delivery of platelet microvesicle-derived microRNAs into human breast cancer cell lines[J].J Nutr Biochem,2019,74:108242.
[39]	ZHEN Z Z,WANG J X,ZHANG Z,et al.Efficacy of early enteral immunonutrition on immune function and clinical outcome for postoperative patients with gastrointestinal cancer[J].JPEN J Parenter Enteral Nutr,2018,42(4):758-765.
[40]	CHENG Y,ZHANG J F,ZHANG L W,et al.Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy:a systematic review and meta-analysis[J].BMC Gastroenterol,2018,18(1):11.
[41]	RODRIGUES V D,DE PINHO N B,ABDELHAY E,et al.Nutrition and immune-modulatory inter-vention in surgical patients with gastric cancer[J].Nutr Clin Pract,2017,32(1):122-129.
[42]	郭志学,王颖,朱娅,等.胃癌胃大部分切除术后早期免疫增强型肠内营养支持治疗效果分析[J].河北医药,2017,39(3):388-389,393.GUO Z X,WANG Y,ZHU Y,et al.Analysis of the effect of early immune enhanced enteral nutritional support after most gastrectomy for gastric cancer[J].Hebei Medical Journal,2017,39(3):388-389,393.(in Chinese)
[43]	HU S E,DONG T S,DALAL S R,et al.The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer[J].PLoS One,2011,6(1):e16221.
[44]	XIONG Y,HANNON G J,ZHANG H,et al.P21 is a universal inhibitor of cyclin kinases[J].Nature,1993,366(6456):701-704.
[45]	OGINO S,NOSHO K,SHIMA K,et al.P21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis[J].Cancer Epidemiol Biomarkers Prev,2009,18(9):2513-2521.
[46]	DAVIE J R.Inhibition of histone deacetylase activity by butyrate[J].J Nutr,2003,133(7):2485S-2493S.
[47]	NAKANO K,MIZUNO T,SOWA Y,et al.Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line[J].J Biol Chem,1997,272(35):22199-22206.
[48]	SCOTT G K,MATTIE M D,BERGER C E,et al.Rapid alteration of microRNA levels by histone deacetylase inhibition[J].Cancer Res,2006,66(3):1277-1281.
[49]	GERMAN J B,DILLARD C J.Composition,structure and absorption of milk lipids:a source of energy,fat-soluble nutrients and bioactive molecules[J].Crit Rev Food Sci,2006,46(1):57-92.
[50]	SALTER A M.Dietary fatty acids and cardiovascular disease[J].Animal,2013,7(S1):163-171.
[51]	ROMAO J M,JIN W W,HE M L,et al.Altered microRNA expression in bovine subcutaneous and visceral adipose tissues from cattle under different diet[J].PLoS One,2012,7(7):e40605.
[52]	ALTENHOFER C,SPORNRAFT M,KIENBERGER H,等.日粮添加菜籽油和大豆油对牛脂肪代谢、脂肪酸组成以及乳汁胆固醇水平的影响[J].饲料博览,2015(1):55.ALTENHOFER C,SPORNRAFT M,KIENBERGER H,et al.Effects of dietary supplementation with rapeseed oil and soybean oil on bovine fat metabolism,fatty acid composition and milk cholesterol level[J].Feed Review,2015(1):5.(in Chinese)
[53]	夏义苗,王欣,陈利华,等.不同氧化条件下葵花籽油脂肪酸含量与低场核磁共振弛豫特性的相关性[J].中国食品学报,2018,18(7):286-294.XIA Y M,WANG X,CHEN L H,et al.The Correlation between fatty acids and LF-NMR relaxation properties in sunflower oil during different oxidation processes[J].Journal of Chinese Institute of Food Science and Technology,2018,18(7):286-294.(in Chinese)
[54]	MOBUCHON L,LE GUILLOU S,MARTHEY S,et al.Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland[J].PLoS One,2017,12(12):e0185511.
[55]	李冉.亚麻籽油与红花油对奶牛乳腺ncRNA的影响及牛奶miRNA表达谱研究[D].杨凌:西北农林科技大学,2016.LI R.Effects of linseed oil and safflower oil on mammary gland mirnome of dairy cows and study on milk mirnome[D].Yangling:Northwest A&F University,2016.(in Chinese)
[56]	NEVILLE M C.Regulation of milk fat synthesis[J].J Pediatr Gastroenterol Nutr,1989,8(4):426-429.
[57]	LERCH S,FERLAY A,SHINGFIELD K J,et al.Rapeseed or linseed supplements in grass-based diets:effects on milk fatty acid composition of Holstein cows over two consecutive lactations[J].J Dairy Sci,2012,95(9):5221-5241.
[58]	LOOR J J,FERLAY A,UEDA K,et al.High-concentrate diets and polyunsaturated oils alter trans and conjugated isomers in bovine rumen,blood,and milk[J].J Dairy Sci,2005,88(11):3986-3999.
[59]	BELL J A,GRIINARI J M,KENNELLY J J.Effect of Safflower Oil,Flaxseed Oil,Monensin,and Vitamin E on Concentration of Conjugated Linoleic Acid in Bovine Milk Fat[J].J Dairy Sci,2006,89(2):733-748.
[60]	IBEAGHA-AWEMU E M,LI R,AMMAH A A,et al.Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways[J].BMC Genomics,2016,17(1):104.
[61]	龙伶俐,薛雅琳,张东,等.油茶籽油主要特征成分的研究分析[J].中国油脂,2012,37(4):78-81.LONG L L,XUE Y L,ZHANG D,et al.Investigation on main characteristic composition of Camellia oleifera seed oil[J].China Oils and Fats,2012,37(4):78-81.(in Chinese)
[62]	赖梅生,杨柳.茶油的药理与临床应用研究进展[J].中医外治杂志,2007,16(3):6-7.LAI M S,YANG L.Research progress of pharmacological action of tea oil and the clinic application[J].Journal of External Therapy of TCM,2007,16(3):6-7.(in Chinese)
[63]	张东生,金青哲,王兴国,等.油茶籽及油营养品质研究现状[J].粮油食品科技,2013,21(4):53-56.ZHANG D S,JIN Q Z,WANG X G,et al.Research status of nutrition quality of camellia oleifera seed and oil[J].Science and Technology of Cereals,Oils and Foods,2013,21(4):53-56.(in Chinese)
[64]	沈建福,姜天甲.山茶油的营养价值与保健功能[J].粮食与食品工业,2006,13(6):6-8,21.SHEN J F,JIANG T J.Nutritional value and health care function of camellia seed oil[J].Cereal and Food Industry,2006,13(6):6-8,21.(in Chinese)
[65]	徐子娴,张涛,雷志良,等.不同功能性油脂对乳腺上皮细胞乳脂合成基因表达的影响[J].中国兽医学报,2017,37(5):949-954.XU Z X,ZHANG T,LEI Z L,et al.Effects of different functional oils on the synthesis of milk fat in mammary epithelial cells[J].Chinese Journal of Veterinary Science,2017,37(5):949-954.(in Chinese)
[66]	SINGH R,YADAV V,KUMAR S,et al.MicroRNA-195 inhibits proliferation,invasion and metastasis in breast cancer cells by targeting FASN,HMGCR,ACACA and CYP27B1[J].Sci Rep,2015,5(1):17454.
[67]	MA X Y,WEI D W,CHENG G,et al.Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle[J].Mol Cell Probe,2018,42:10-17.
[68]	SUN X D,LUO S B,JIANG C H,et al.Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide,by inactivating NF-κB signaling[J].J Dairy Sci,2020,103(9):8388-8397.
[69]	SHARMIN M M,MIZUSAWA M,HAYASHI S,et al.Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells[J].J Dairy Sci,2020,103(9):8643-8654.
[70]	YAN Q X,TANG S X,ZHOU C S,et al.Effects of free fatty acids with different chain lengths and degrees of saturability on the milk fat synthesis in primary cultured bovine mammary epithelial cells[J].J Agric Food Chem,2019,67(31):8485-8492.

Research Progress of Fatty Acid Regulation of microRNAs in Dairy Cow Mammary Glands

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