糖肽类抗生素的研究进展

doi:10.11843/j.issn.0366-6964.2020.07.002

Abstract

Abstract: Glycopeptide antibiotics, especially vancomycin, are effective drugs for clinical treatment of multiple drug-resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). With the development of bacterial drug resistance, the problem of glycopeptide antibiotic resistance is becoming more and more serious, so it is very urgent to find and develop new compounds for clinical treatment. This paper reviews the action and resistance mechanism of glycopeptide antibiotics, newly approved glycopeptide antibiotics, chemical modification and new screening and development methods, in order to provide ideas for the development of glycopeptide antibiotics.

Key words: multi-drug-resistant bacteria, glycopeptide antibiotics, chemical modification, screening and development

CLC Number:

S859.7

DONG Zhen, CHEN Chen, LI Bing, ZHOU Xuzheng, ZHANG Jiyu. Research Progress of Glycopeptide Antibiotics[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(7): 1488-1498.

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Research Progress of Glycopeptide Antibiotics

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