哺乳动物子宫自然杀伤(uNK)细胞对妊娠的调控作用

doi:10.11843/j.issn.0366-6964.2020.05.001

Abstract

Abstract: Uterine natural killer cells are the most abundant immune cells in deciduate placenta in the early pregnancy of mammals. During pregnancy, uNK cells play the important regulation role in the establishment of uterine immunotolerance environment, the development of placenta and fetus. However, studies on the regulation mechanisms of unique biological activity of uNK cells in pregnancy are limited. According to the related researches, the presentation of the important regulation role of uNK cells in the establishment of maternal-fetal immunotolerance environment and the development of placenta and fetus were well given in this paper, and the regulatory mechanism of hormones, glucose metabolism and DNA methylation on NK cells in other tissues were well summarized in order to provide new research directions and ideas for exploring the molecular regulation mechanism of uNK cells.

Key words: uterine natural killer cells, pregnancy, regulation role

CLC Number:

S852.4

YANG Xiaowei, ZHAO Yongju. The Regulation Role of Uterine Natural Killer (uNK) Cells during Pregnancy in Mammals[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(5): 899-906.

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The Regulation Role of Uterine Natural Killer (uNK) Cells during Pregnancy in Mammals

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