动物源宿主防御肽抗微生物作用机制研究进展

doi:10.11843/j.issn.0366-6964.2025.09.014

摘要/Abstract

摘要：

宿主防御肽(host defense peptides, HDPs)是广泛存在于宿主体内的小分子多肽，在天然免疫抵御病原感染中发挥重要作用。宿主防御肽具有广谱抗微生物活性且不易产生耐药，是开发新型抗感染药物的潜在候选药物。但是宿主防御肽的抗微生物作用机制复杂，不仅可以作用于细胞壁、细胞膜，也可以影响细胞内核酸、蛋白质及代谢，本文综述了宿主防御肽对细菌、真菌、病毒、寄生虫等病原体的作用机制，为宿主防御肽的应用提供参考。

关键词: 宿主防御肽, 微生物, 作用机制

Abstract:

Host defense peptides (HDPs), as antimicrobial peptides (AMPs), are an important component of innate immunity and can protect the host against pathogens invasion. HDPs have broad-spectrum antimicrobial activity and are less susceptible to the production to drug resistance, which are potential candidates for the development of new anti-infectives. The antibacterial mechanism of action of HDPs is complicated, which not only acts on cell wall and membrane, but also affects the synthesis of nucleic acid, protein and metabolism. This article reviews the mechanism of action of HDPs on pathogens including bacteria, fungi, viruses, and parasites, which provides reference for the application of HDPs.

Key words: host defense peptides, microorganisms, the mechanism of action

中图分类号:

S852.42

潘言迪, 张婷婷, 方仁东, 彭练慈. 动物源宿主防御肽抗微生物作用机制研究进展[J]. 畜牧兽医学报, 2025, 56(9): 4294-4302.

PAN Yandi, ZHANG Tingting, FANG Rendong, PENG Lianci. Research Progress on the Mechanism of Host Defense Peptides against Microorganisms[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4294-4302.

图/表 1

参考文献 65

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