昼夜节律与雌激素协同调控哺乳动物生殖的研究进展

doi:10.11843/j.issn.0366-6964.2023.05.001

摘要/Abstract

摘要： 昼夜节律系统是哺乳动物的内部计时系统,在大多数动物中,下丘脑视交叉神经上核(suprachiasmatic nucleus, SCN)是主要的昼夜节律时钟,通过协调动物机体各个组织的时钟使内部节律与环境周期一致。SCN核心区细胞能够直接从内在光敏视网膜神经节细胞(intrinsically photosensitive retinal ganglion cell, ipRGCs)接收光信号,其内源性振荡决定了整个动物的行为和生理节律。雌激素能够调节哺乳动物的多个生理过程,包括但不限于发情周期的节律行为,雌激素通过和SCN协同调节GnRH分泌、LH峰以及排卵,最终影响哺乳动物的生殖过程。本文综述了哺乳动物雌激素分泌和昼夜节律、雌激素和昼夜节律之间的分子联系以及二者对雌性哺乳动物繁殖调控机制3个方面的最新研究进展,以期为深入探究雌性哺乳动物繁殖的节律和激素调控机制提供参考。

关键词: 哺乳动物, 昼夜节律, 雌激素, 下丘脑视交叉上核, 繁殖调控

Abstract: The circadian system is an internal timer system in most mammals, as the main circadian clock, the hypothalamic suprachiasmatic nucleus (SCN) coordinates the timing of the organizational clock to align internal rhythms with environmental cycles. Cells in the SCN core are capable of receiving light signaling directly from intrinsically photosensitive retinal ganglion cells (ipRGCs), whose endogenous oscillations determine behavioral and physiological rhythms throughout the animal. Estrogen is capable of regulating a variety of biological processes of mammals, including but not limited to the circadian rhythmic behavior of the estrous cycle. Estrogen and SCN synergistically regulate GnRH secretion, LH peak, ovulation, and resulting in the regu-lation of the mammalian reproductive process. This paper reviews the recent research progress in the mutual regulation of estrogen and circadian rhythm in female mammals, including the phenomenon of estrogen secretion and circadian rhythm, the molecular link between estrogen and circadian rhythm, and their regulation mechanism on the reproduction of female mammals. These results can provide a reference for further exploration of the reproductive rhythm and hormone regulation mechanism of female mammals.

Key words: mammals, circadian rhythm, estrogen, SCN, reproduction regulation

中图分类号:

S811.4

王唯, 贺小云, 储明星. 昼夜节律与雌激素协同调控哺乳动物生殖的研究进展[J]. 畜牧兽医学报, 2023, 54(5): 1771-1781.

WANG Wei, HE Xiaoyun, CHU Mingxing. Advances in the Regulation of Mammal Reproduction by the Interaction of Circadian Rhythm and Estrogens[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1771-1781.

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