哺乳动物胎盘营养感应研究进展

doi:10.11843/j.issn.0366-6964.2022.05.001

摘要/Abstract

摘要： 妊娠期间母体营养的改变会影响胎儿的生长发育，而胎盘是母体-胎儿间进行气体、营养和代谢物交流的重要枢纽，哺乳动物胎盘营养感应系统响应母体和胎儿营养信号的变化，保证母体健康和胎儿生长发育。鉴于胎盘营养感应系统对哺乳动物繁育的重要性，本文从胎盘营养感应和胎盘养分分配方面综述了哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin，mTOR)、磷酸腺苷活化蛋白激酶(AMP-activated protein kinase，AMPK)、氨基己糖(Hexosamine)信号通路、糖原合成酶3(glycogen synthase kinase，GSK-3)、胰岛素/胰岛素样生长因子(insulin/insulin-like growth factor signaling pathway，IIS)等信号通路及其对妊娠期养分响应和对胎儿发育的影响，以期为哺乳动物的繁育提供参考依据。

关键词: 哺乳动物, 胎盘营养感应, 胎盘养分分配, 信号通路

Abstract: Changes in maternal nutrition during gestation will affect the growth and development of the fetus. Placenta is an important interface for gas, nutrition and metabolite communication between maternal and fetus. The mammalian placental nutrition sensing system responds to the changes in maternal and fetal signals to ensure maternal health and promote the fetal growth and development. In view of its important role of the placental nutrition sensing system to mammalian reproduction, this article summarizes the effects of relevant signaling pathways including mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), hexosamine signaling pathway (Hexosamine), hlycogen synthase kinase 3 (GSK-3), insulin/insulin-like growth factor signaling pathway (IIS) and others on placental nutrition sensing and placental nutrient distribution to response nutrient changes in dam, subsequently to influence fetal development during pregnancy. All above are expected to provide theoretical basis for the breeding of mammals.

Key words: mammalian, placental nutrition sensing, placental nutrient distribution, signaling pathway

中图分类号:

S814.1

刘月帅, 刘彦, 曹忻, 冯涛. 哺乳动物胎盘营养感应研究进展[J]. 畜牧兽医学报, 2022, 53(5): 1321-1333.

LIU Yueshuai, LIU Yan, CAO Xin, FENG Tao. Research Progress on Mammalian Placental Nutrition Sensing[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1321-1333.

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