布鲁氏菌脂多糖的生物合成及其在免疫逃逸中的生物学功能

doi:10.11843/j.issn.0366-6964.2025.10.009

摘要/Abstract

摘要：

布鲁氏菌病(brucellosis)是由布鲁氏菌(Brucella spp.)侵染引起的一种人畜共患细菌病, 严重危害人类健康和养殖业发展。布鲁氏菌是一种胞内寄生菌, 逃避宿主天然免疫反应实现胞内寄生是布鲁氏菌毒力的重要体现。脂多糖(LPS)是布鲁氏菌编码的重要毒力因子之一。相较于其他革兰阴性菌, 布鲁氏菌LPS的主要成分、空间结构、连接方式均有不同, 使其表现出特有的低内毒素性, 并且在协助布鲁氏菌逃逸宿主天然免疫系统的识别以及调控免疫应答过程中起关键作用。本文聚焦布鲁氏菌LPS, 对其特殊结构、生物合成过程及其免疫逃逸机制进行综述, 为全面了解布鲁氏菌LPS的生物学功能奠定基础。

关键词: 布鲁氏菌, 脂多糖, 胞内寄生, 免疫逃逸

Abstract:

Brucellosis is a zoonotic bacterial disease caused by Brucella spp., which poses a serious threat to human health and the development of the livestock industry. Brucella is an intracellular pathogen, and its ability to evade the host's innate immune response and survive within host cells is a key aspect of its virulence. Lipopolysaccharide (LPS) is one of the major virulence factors encoded by Brucella. Compared to other Gram-negative bacteria, the main components, spatial structure, and linkage of Brucella LPS are distinct, which results in its unique low endotoxicity. Moreover, Brucella LPS plays a crucial role in helping the bacteria evade recognition by the host's immune system and in modulating immune responses. This review focuses on Brucella LPS, reviewing its unique structure, biosynthesis process, and immune evasion mechanisms, thereby laying the foundation for a comprehensive understanding of the biological functions of Brucella LPS.

Key words: Brucella, lipopolysaccharides, intracellular survival, immune evasion

中图分类号:

R378.5

王恒泰, 蒋卉, 李朋, 丁家波. 布鲁氏菌脂多糖的生物合成及其在免疫逃逸中的生物学功能[J]. 畜牧兽医学报, 2025, 56(10): 4863-4876.

WANG Hengtai, JIANG Hui, LI Peng, DING Jiabo. Biosynthesis of Brucella Lipopolysaccharides and Their Biological Functions in Immune Evasion[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(10): 4863-4876.

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蛋白 Protein	与铜绿假单胞菌相似性 Similarity with Pseudomonas	与沙门菌相似性 Similarity with Salmonella
LpxA	38.43	39.22
LpxC	43.11	39.22
LpxD	38.30	37.74
LpxB	32.44	32.58
LpxK	36.49	34.81
LpxL	36.49	34.81

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