赤羽病病毒与宿主相互作用机制研究进展

doi:10.11843/j.issn.0366-6964.2025.10.010

摘要/Abstract

摘要：

赤羽病病毒(Akabane virus, AKAV) 是一种能够引起牛、羊等反刍动物以繁殖障碍为主要特征的虫媒性病原, 广泛分布于热带、温带蚊、蠓等吸血昆虫较为集中的区域, 特别是东南亚和东亚一些国家尤为严重, 我国部分地区呈现区域性流行。随着牛羊养殖集约化程度的提高, 交易运输频繁, 以及气候变化引起媒介昆虫孳生范围扩大等原因, 该病有进一步扩大感染的趋势。本文自AKAV的病原特征和组织嗜性入手, 着重从病毒侵染宿主细胞以及宿主的应答反应两个方面阐述其相互作用机制, 为深入探究AKAV的致病机理, 开发相应治疗药物及预防制剂等提供参考。

关键词: 赤羽病病毒, 致病机制, 病毒复制, 干扰素, 细胞凋亡

Abstract:

Akabane virus (AKAV) is a vector-borne pathogen that primarily causes reproductive disorders in ruminants such as cattle and sheep. It is widely distributed in areas where blood- sucking insects such as mosquitoes and midges are concentrated in tropical and temperate regions. The infection situation is particularly severe in some Southeast Asian and East Asian countries. Regional epidemics have been found in China. With the increasing intensification of cattle and sheep farming, frequent trading and transportation, and the expansion of the breeding range of vector insects due to climate change, the disease has a further trend of spreading infection. In this paper, beginning with pathogenic characteristics and tissue tropism of AKAV, the interaction mechanisms between virus infection and the host′s responses were summarized emphatically. It could provide a reference for further exploration of the pathogenesis of AKAV and the development of corresponding therapeutic drugs and preventive preparations.

Key words: Akabane virus, pathogenic mechanism, viral replication, interferon, apoptosis

中图分类号:

S852.65

冯玉环, 张艺千, 刘霞, 周学慧, 刘言言, 牛禄婷, 倪兴维, 赵治国, 王艳, 杨晓伟, 徐婷婷, 赵光伟. 赤羽病病毒与宿主相互作用机制研究进展[J]. 畜牧兽医学报, 2025, 56(10): 4877-4888.

FENG Yuhuan, ZHANG Yiqian, LIU Xia, ZHOU Xuehui, LIU Yanyan, NIU Luting, NI Xingwei, ZHAO Zhiguo, WANG Yan, YANG Xiaowei, XU Tingting, ZHAO Guangwei. Research Progress on the Interaction Mechanisms between Akabane Virus and Host[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(10): 4877-4888.

图/表 4

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