畜牧兽医学报 ›› 2021, Vol. 52 ›› Issue (1): 1-8.doi: 10.11843/j.issn.0366-6964.2021.001

• 综述 •    下一篇

线粒体自噬调节雌性动物生殖功能的研究进展

房晓欢1, 李俊杰1,2*   

  1. 1. 河北农业大学动物科技学院, 保定 071000;
    2. 河北省牛羊胚胎技术创新中心, 保定 071000
  • 收稿日期:2020-07-13 出版日期:2021-01-23 发布日期:2021-01-19
  • 通讯作者: 李俊杰,主要从事动物繁殖与配子/胚胎生物技术研究,E-mail:lijunjie816@163.com
  • 作者简介:房晓欢(1994-),女,河北衡水人,博士生,主要从事动物繁殖与配子/胚胎生物技术研究,E-mail:fangxiaohuan94@163.com
  • 基金资助:
    河北省自然科学基金(C2019204260);河北省高等学校科学技术研究项目(ZD2020108);河北农业大学精准畜牧学科群建设项目(1090064)

Research Progress of Mitophagy on Regulating Female Reproductive Function in Animals

FANG Xiaohuan1, LI Junjie1,2*   

  1. 1. College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China;
    2. Hebei Technology Innovation Center of Cattle and Sheep Embryo, Baoding 071000, China
  • Received:2020-07-13 Online:2021-01-23 Published:2021-01-19

摘要: 线粒体是一种广泛存在于真核细胞并为机体提供能量的细胞器,其自噬对于清除功能障碍的线粒体,维持线粒体的动态平衡和细胞稳态具有重要意义。近年来,线粒体自噬对雌性动物生殖的影响愈发受到关注。本文在线粒体自噬生理功能基础上,从雌性动物主要生殖器官与组织、卵母细胞、颗粒细胞及胚胎等方面综述了线粒体自噬对雌性动物生殖功能的影响。

关键词: 线粒体自噬, 雌性动物, 生殖, 进展

Abstract: Mitochondria are an organelle that widely exists in eukaryotic cells and provide energy for the body. Mitophagy is of great significance on clearing dysfunctional mitochondria, maintaining mitochondrial dynamic equilibrium and cellular homeostasis. In recent years, the effect of mitophagy on female reproduction in animals received increasing attention. Based on the physiological function of mitophagy, the effect of mitophagy on female reproductive function in the aspects of main reproductive organs and tissues, oocytes, granulosa cells and embryos of female animals were reviewed in this article.

Key words: mitophagy, female animal, reproduction, progresses

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