植物多酚在家禽领域应用研究进展

doi:10.11843/j.issn.0366-6964.2023.11.006

摘要/Abstract

摘要： 植物多酚是植物的次级代谢产物,植物来源的多酚按结构常分为黄酮类、非黄酮类和单宁。随着饲用抗生素在全世界畜禽养殖领域的禁用,植物来源的多酚因其明显的抑菌、抗炎、抗病毒、抗应激、抗氧化等活性引起畜牧生产领域广泛兴趣和关注。本文系统地综述了植物多酚在家禽领域的应用研究进展,为植物多酚在家禽领域的科学应用提供理论参考。

关键词: 多酚, 家禽, 研究进展

Abstract: Plant polyphenols are secondary metabolites of plants, and plant-derived polyphenols are often classified into flavonoids, non-flavonoids and tannins according to their structure. With the ban of feed antibiotics in livestock and poultry farming worldwide, plant-derived polyphenols have attracted wide interest and attention in the field of livestock production because of their obvious antibacterial, anti-inflammatory, antiviral, anti-stress and antioxidant activities. This paper systematically reviews the research progress of plant polyphenols in poultry field, and provides theoretical references for the scientific application of plant polyphenols in poultry field.

Key words: polyphenols, poultry, research progress

中图分类号:

S831.5

毕睿晨, 刘相泽, 胡泽琼, 杨美雪, 乔嘉宁, 黄嘉, 郭芳申, 孔令华, 王忠. 植物多酚在家禽领域应用研究进展[J]. 畜牧兽医学报, 2023, 54(11): 4488-4501.

BI Ruichen, LIU Xiangze, HU Zeqiong, YANG Meixue, QIAO Jianing, HUANG Jia, GUO Fangshen, KONG Linghua, WANG Zhong. Research Progress on the Application of Plant Polyphenols in Poultry Field[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4488-4501.

参考文献 109

[1]	TANGNEY C C,RASMUSSEN H E.Polyphenols,inflammation,and cardiovascular disease[J].Curr Atheroscler Rep,2013,15(5):324.
[2]	GRASSIA M,SALVATORI G,ROBERTI M,et al.Polyphenols,methylxanthines,fatty acids and minerals in cocoa beans and cocoa products[J].J Food Meas Charact,2019,13(3):1721-1728.
[3]	郝霄鹏.植物多酚的提取工艺、生物学功能及其在动物生产中应用的研究进展[J].饲料研究,2021,44(23):153-156.HAO X P.Research progress on extraction process,biological function and application of plant polyphenols in animal production[J].Feed Research,2021,44(23):153-156.(in Chinese)
[4]	LIPIŃSKI K,MAZUR M,ANTOSZKIEWICZ Z,et al.Polyphenols in monogastric nutrition-a review[J].Ann Anim Sci,2017,17(1):41-58.
[5]	DI LORENZO C,COLOMBO F,BIELLA S,et al.Polyphenols and human health:the role of bioavailability[J].Nutrients,2021,13(1):273.
[6]	AL-MNASER A,DAKHEEL M,ALKANDARI F,et al.Polyphenolic phytochemicals as natural feed additives to control bacterial pathogens in the chicken gut[J].Arch Microbiol,2022,204(5):253.
[7]	RUAN D,WU S W,FOUAD A M,et al.Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens[J].Food Funct,2022,13(22):11811-11824.
[8]	XIE Z L,SHEN G Z,WANG Y,et al.Curcumin supplementation regulates lipid metabolism in broiler chickens[J].Poult Sci,2019,98(1):422-429.
[9]	WANG D F,HUANG H F,ZHOU L L,et al.Effects of dietary supplementation with turmeric rhizome extract on growth performance,carcass characteristics,antioxidant capability,and meat quality of Wenchang broiler chickens[J].Ital J Anim Sci,2015,14(3):3870.
[10]	VIVEROS A,CHAMORRO S,PIZARRO M,et al.Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks[J].Poult Sci,2011,90(3):566-578.
[11]	IHAFSA S H A,IBRAHIM S A.Effect of dietary polyphenol-rich grape seed on growth performance,antioxidant capacity and ileal microflora in broiler chicks[J].J Anim Physiol Anim Nutr (Berl),2018,102(1):268-275.
[12]	BRENES A,VIVEROS A,GOÑI I,et al.Effect of grape pomace concentrate and vitamin E on digestibility of polyphenols and antioxidant activity in chickens[J].Poult Sci,2008,87(2):307-316.
[13]	FRÓES H G,JÁCOME I M T D,TAVARES R A,et al.Grape (Vitis vinifera) pomace flour as pigment agent of quail eggs[J].Rev Bras Cienc Avic,2018,20(1):183-188.
[14]	AO X,KIM I H.Effects of grape seed extract on performance,immunity,antioxidant capacity,and meat quality in Pekin ducks[J].Poult Sci,2020,99(4):2078-2086.
[15]	TANG Y,ZHANG X Y,WANG Y N,et al.Dietary ellagic acid ameliorated Clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota[J].J Anim Sci Biotechnol,2022,13(1):47.
[16]	CHEN F,ZHANG H,DU E C,et al.Effects of magnolol on egg production,egg quality,antioxidant capacity,and intestinal health of laying hens in the late phase of the laying cycle[J].Poult Sci,2021,100(2):835-843.
[17]	ERINLE T J,MACISAAC J,YANG C B,et al.Effect of red osier dogwood extract on growth performance,blood biochemical parameters,and gut functionality of broiler chickens challenged or unchallenged intraperitoneally with Salmonella enteritidis lipopolysaccharide[J].Poult Sci,2022,101(7):101861.
[18]	李瑞卿.茶渣饲料对浙东白鹅生长性能、屠宰性能及肠道发育的影响研究[D].乌鲁木齐:新疆农业大学,2022.LI R Q.Effect of tea residue feed on growth performance,slaughter performance and intestinal development of Zhedong white goose[D].Urumqi:Xinjiang Agricultural University,2022.(in Chinese)
[19]	SCHIAVONE A,GUO K,TASSONE S,et al.Effects of a natural extract of chestnut wood on digestibility,performance traits,and nitrogen balance of broiler chicks[J].Poult Sci,2008,87(3):521-527.
[20]	JAMROZ D,WILICZKIEWICZ A,SKORUPI AN＇G SKA J,et al.Effect of sweet chestnut tannin (SCT) on the performance,microbial status of intestine and histological characteristics of intestine wall in chickens[J].Br Poult Sci,2009,50(6):687-699.
[21]	REDONDO E A,REDONDO L M,BRUZZONE O A,et al.Effects of a blend of chestnut and quebracho tannins on gut health and performance of broiler chickens[J].PLoS One,2022,17(1):e0254679.
[22]	STAR AČG EVIĆ K,KRSTULOVIĆ L,BROZIĆ D,et al.Production performance,meat composition and oxidative susceptibility in broiler chicken fed with different phenolic compounds[J].J Sci Food Agric,2015,95(6):1172-1178.
[23]	MADSEN H L,BERTELSEN G.Spices as antioxidants[J].Trends Food Sci Technol,1995,6(8):271-277.
[24]	MAESTRE R,MICOL V,FUNES L,et al.Incorporation and interaction of grape seed extract in membranes and relation with efficacy in muscle foods[J].J Agric Food Chem,2010,58(14):8365-8374.
[25]	ADEYEMI K,BALOGUN M,BABALOLA O,et al.Dietary supplementation of Solanum aethiopicum and Solanecio biafrae leaves alters stress and immune responses,antioxidant status,and meat quality in broilers raised in a hot-dry environment[J].Br Poult Sci,2022,63(1):82-90.
[26]	SIERŻANT K,KORZENIOWSKA M,PÓȽBRAT T,et al.The use of an optimised concentration of quercetin limits peroxidation of lipids in the meat of broiler chickens fed a diet containing flaxseed oil rich in omega-3[J].Animal,2022,16(8):100603.
[27]	YU Q F,FANG C K,MA Y J,et al.Dietary resveratrol supplement improves carcass traits and meat quality of Pekin ducks[J].Poult Sci,2021,100(3):100802.
[28]	ZHANG J F,HU Z P,LU C H,et al.Effect of various levels of dietary curcumin on meat quality and antioxidant profile of breast muscle in broilers[J].J Agric Food Chem,2015,63(15):3880-3886.
[29]	CHEN X Y,LI T,HE K Q,et al.Dietary green tea powder supplementation enriched egg nutrients and physicochemical property in an indigenous chickenbreed[J].Poult Sci,2021,100(1):388-395.
[30]	XIA B,LIU Y L,SUN D,et al.Effects of green tea powder supplementation on egg production and egg quality in laying hens[J].J Appl Anim Res,2018,46(1):927-931.
[31]	WANG J P,JIA R,CELI P,et al.Green tea polyphenol epigallocatechin-3-gallate improves the antioxidant capacity of eggs[J].Food Funct,2020,11(1):534-543.
[32]	OBIANWUNA U E,OLEFORUH-OKOLEH V U,WANG J,et al.Natural products of plants and animal origin improve albumen quality of chicken eggs[J].Front Nutr,2022,9:875270.
[33]	WANG J,YUAN Z,ZHANG K,et al.Epigallocatechin-3-gallate protected vanadium-induced eggshell depigmentation via P38MAPK-Nrf2/HO-1 signaling pathway in laying hens[J].Poult Sci,2018,97(9):3109-3118.
[34]	THØFNER I C N,POULSEN L L,BISGAARD M,et al.Correlation between footpad lesions and systemic bacterial infections in broiler breeders[J].Vet Res,2019,50(1):38.
[35]	CENGIZ Ö,HESS J B,BILGILI S F.Feed enzyme supplementation does not ameliorate foot pad dermatitis in broiler chickens fed on a corn-soyabean diet[J].Br Poult Sci,2012,53(4):401-407.
[36]	CENGIZ Ö,KÖKSAL B H,TATLI O,et al.Effect of dietary tannic acid supplementation in corn- or barley-based diets on growth performance,intestinal viscosity,litter quality,and incidence and severity of footpad dermatitis in broiler chickens[J].Livest Sci,2017,202:52-57.
[37]	REZAR V,SALOBIR J.Effects of tannin-rich sweet chestnut (Castanea sativa mill.) wood extract supplementation on nutrient utilisation and excreta dry matter content in broiler chickens[J].Eur Poult Sci,2014,78.
[38]	BILAL R M,LIU C J,ZHAO H H,et al.Olive oil:nutritional applications,beneficial health aspects and its prospective application in poultry production[J].Front Pharmacol,2021,12:723040.
[39]	代燕丽,邹宇晓,刘凡,等.植物多酚干预脂质代谢紊乱作用机制研究进展[J].中国中药杂志,2015,40(21):4136-4141.DAI Y L,ZOU Y X,LIU F,et al.Review:plant polyphenols modulate lipid metabolism and related molecular mechanism[J].China Journal of Chinese Materia Medica,2015,40(21):4136-4141.(in Chinese)
[40]	MADKOUR M,SALMAN F M,EL-WARDANY I,et al.Mitigating the detrimental effects of heat stress in poultry through thermal conditioning and nutritional manipulation[J].J Therm Biol,2022,103:103169.
[41]	ZHANG J F,BAI K W,SU W P,et al.Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens[J].Poult Sci,2018,97(4):1209-1219.
[42]	ZHANG J F,HU Z P,LU C H,et al.Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway[J].J Anim Sci,2015,93(4):1656-1665.
[43]	AKHAVAN-SALAMAT H,GHASEMI H A.Alleviation of chronic heat stress in broilers by dietary supplementation of betaine and turmeric rhizome powder:dynamics of performance,leukocyte profile,humoral immunity,and antioxidant status[J].Trop Anim Health Prod,2016,48(1):181-188.
[44]	RUAN D,ZHU Y W,FOUAD A M,et al.Dietary curcumin enhances intestinal antioxidant capacity in ducklings via altering gene expression of antioxidant and key detoxification enzymes[J].Poult Sci,2019,98(9):3705-3714.
[45]	ZHANG C,ZHAO X H,YANG L,et al.Resveratrol alleviates heat stress-induced impairment of intestinal morphology,microflora,and barrier integrity in broilers[J].Poult Sci,2017,96(12):4325-4332.
[46]	WANG C,ZHAO F,LI Z,et al.Effects of resveratrol on growth performance,intestinal development,and antioxidant status of broilers under heat stress[J].Animals (Basel),2021,11(5):1427.
[47]	LIU L L,FU C X,YAN M L,et al.Resveratrol modulates intestinal morphology and HSP70/90,NF-κB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress[J].Food Funct,2016,7(3):1329-1338.
[48]	ZHOU N,TIAN Y,WU H Z,et al.Protective effect of resveratrol on immortalized duck intestinal epithelial cells exposed to H2O2[J].Molecules,2022,27(11):3542.
[49]	WANG M L,SUO X,GU J H,et al.Influence of grape seed proanthocyanidin extract in broiler chickens:effect on chicken coccidiosis and antioxidant status[J].Poult Sci,2008,87(11):2273-2280.
[50]	SUN L,XU G Q,DONG Y Y Y,et al.Quercetin protects against lipopolysaccharide-induced intestinal oxidative stress in broiler chickens through activation of Nrf2 pathway[J].Molecules,2020,25(5):1053.
[51]	ULLUWISHEWA D,RACHEL C A,WARREN C M,et al.Regulation of tight junction permeability by intestinal bacteria and dietary components[J].J Nutr,2011,141(5):769-776.
[52]	吴姝,蒋步云,宋泽和,等.植物多酚对黄羽肉鸡抗氧化性能、肠道形态及肉品质的影响[J].动物营养学报,2018,30(12):5118-5126.WU S,JIANG B Y,SONG Z H,et al.Effects of botanical polyphenol on antioxidant capacity,intestinal morphology and meat quality of yellow broilers[J].Chinese Journal of Animal Nutrition,2018,30(12):5118-5126.(in Chinese)
[53]	KAMBOH A A,ZHU W Y.Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens[J].Poult Sci,2014,93(9):2175-2183.
[54]	COLOMBINO E,FERROCINO I,BIASATO I,et al.Dried fruit pomace inclusion in poultry diet:growth performance,intestinal morphology and physiology[J].J Anim Sci Biotechnol,2020,11:63.
[55]	CHAMORRO S,ROMERO C,BRENES A,et al.Impact of a sustained consumption of grape extract on digestion,gut microbial metabolism and intestinal barrier in broiler chickens[J].Food Funct,2019,10(3):1444-1454.
[56]	ZHANG X H,ZHAO Q Q,CI X T,et al.Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury,oxidative stress,and inflammation in chickens challenged with Clostridium perfringens type A[J].Poult Sci,2020,99(12):6606-6618.
[57]	DONG Y Y,LEI J Q,ZHANG B K.Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil[J].Poult Sci,2020,99(10):4892-4903.
[58]	AMEVOR F K,CUI Z F,DU X X,et al.Supplementation of dietary quercetin and vitamin E promotes the intestinal structure and immune barrier integrity in aged breeder hens[J].Front Immunol,2022,13:860889.
[59]	DING X M,CAI C Y,JIA R,et al.Dietary resveratrol improved production performance,egg quality,and intestinal health of laying hens under oxidative stress[J].Poult Sci,2022,101(6):101886.
[60]	付晶,邓珊,陈艾玲,等.茶多酚对乳鸽十二指肠形态发育、抗氧化功能和紧密连接蛋白基因mRNA表达的影响[J].东北农业大学学报,2021,52(12):31-39.FU J,DENG S,CHEN A L,et al.Effects of tea polyphenols (TP) on morphological development,antioxidant function and mRNA expression level of intestinal tight junction protein genes in duodenum of squabs[J].Journal of Northeast Agricultural University,2021,52(12):31-39.(in Chinese)
[61]	LI X,SUN R P,LIU Q W,et al.Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance,antioxidant function,intestinal morphology,and microbiota composition in Wenchang chickens[J].Front Vet Sci,2023,9:1073659.
[62]	黄小丹,陈梦雨,黄文洁,等.基于代谢组学的植物多酚及其肠道健康效应研究进展[J].生物技术通报,2021,37(1):123-136.HUANG X D,CHEN M Y,HUANG W J,et al.Progress based on metabolomics:plant polyphenols and their gut health benefit[J].Biotechnology Bulletin,2021,37(1):123-136.(in Chinese)
[63]	KUMAR SINGH A,CABRAL C,KUMAR R,et al.Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency[J].Nutrients,2019,11(9):2216.
[64]	WAN M L Y,CO V A,EL-NEZAMI H.Dietary polyphenol impact on gut health and microbiota[J].Crit Rev Food Sci Nutr,2021,61(4):690-711.
[65]	SELMA M V,ESPÍN J C,TOMÁS-BARBERÁN F A.Interaction between phenolics and gut microbiota:role in human health[J].J Agric Food Chem,2009,57(15):6485-6501.
[66]	SURAI P F.Polyphenol compounds in the chicken/animal diet:from the past to the future[J].J Anim Physiol Anim Nutr (Berl),2014,98(1):19-31.
[67]	HAJATI H,HASSANABADI A,GOLIAN A G,et al.The effect of grape seed extract and vitamin C feed supplements on carcass characteristics,gut morphology and ileal microflora in broiler chickens exposed to chronic heat stress[J].Iran J Appl Anim Sci,2015,5(1):155-165.
[68]	MATTIO L M,DALLAVALLE S,MUSSO L,et al.Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens[J].Sci Rep,2019,9(1):19525.
[69]	SAMUEL K G,WANG J,YUE H Y,et al.Effects of dietary gallic acid supplementation on performance,antioxidant status,and jejunum intestinal morphology in broiler chicks[J].Poult Sci,2017,96(8):2768-2775.
[70]	LIU H N,LIU Y,HU L L,et al.Effects of dietary supplementation of quercetin on performance,egg quality,cecal microflora populations,and antioxidant status in laying hens[J].Poult Sci,2014,93(2):347-353.
[71]	BRENES A,VIVEROS A,CHAMORRO S,et al.Use of polyphenol-rich grape by-products in monogastric nutrition.A review[J].Anim Feed Sci Tech,2016,211:11-17.
[72]	IQBAL Y,COTTRELL J J,SULERIA H A R,et al.Gut microbiota-polyphenol interactions in chicken:a review[J].Animals (Basel),2020,10(8):1391.
[73]	DAS Q,ISLAM R,LEPP D,et al.Gut microbiota,blood metabolites,and spleen immunity in broiler chickens fed berry pomaces and phenolic-enriched extractives[J].Front Vet Sci,2020,7:150.
[74]	AHMED S T,YANG C J.Effects of dietary Punica granatum L. by-products on performance,immunity,intestinal and fecal microbiology,and odorous gas emissions from excreta in broilers[J].J Poult Sci,2017,54(2):157-166.
[75]	HASTED T L,SHARIF S,BOERLIN P,et al.Immunostimulatory potential of fruits and their extracts in poultry[J].Front Immunol,2021,12:641696.
[76]	ISLAM R,OOMAH D B,DIARRA M S.Potential immunomodulatory effects of non-dialyzable materials of cranberry extract in poultry production[J].Poult Sci,2017,96(2):341-350.
[77]	VIERA K,KATARÍNA B,MARTIN L,et al.The influence of farmatan® and flimabend® on the mucosal immunity of broiler chicken[J].Poult Sci,2019,98(3):1161-1166.
[78]	RAMAH A,YASUDA M,OHASHI Y,et al.Different doses of tannin reflect a double-edged impact on broiler chicken immunity[J].Vet Immunol Immunopathol,2020,220:109991.
[79]	LEE A,DAL PONT G C,FARNELL M B,et al.Supplementing chestnut tannins in the broiler diet mediates a metabolic phenotype of the ceca[J].Poult Sci,2021,100(1):47-54.
[80]	LEE A,DAL PONT G C,BATTAGLIA M,et al.Role of JAK-STAT pathway in broiler chicks fed with chestnut tannins[J].Animals (Basel),2021,11(2):337.
[81]	张海军,徐磊,岳洪源,等.葡多酚对肉鸡生产性能和免疫机能的影响[J].中国畜牧兽医,2012,39(3):99-103.ZHANG H J,XU L,YUE H Y,et al.Effect of grape procyanidins on growth performance and immune function in broilers[J].China Animal Husbandry & Veterinary Medicine,2012,39(3):99-103.(in Chinese)
[82]	MAGNE K,MERETE H.Barley inclusion and avoparcin supplementation in broiler diets.:2.clinical,pathological,and bacteriological findings in a mild form of necrotic enteritis[J].Poult Sci,1992,71(7):1145-1153.
[83]	NAVARRO-MARTINEZ M D,NAVARRO-PERAN E,CABEZAS-HERRERA J,et al.Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia[J].Antimicrob Agents Chemother,2005,49(7):2914-2920.
[84]	MAHFUZ S,SHANG Q H,PIAO X S.Phenolic compounds as natural feed additives in poultry and swine diets:a review[J].J Anim Sci Biotechnol,2021,12(1):48.
[85]	HELENO S A,FERREIRA I C F R,C[DD(-2]＇IRIC[DD(-2]＇ A,et al.Coprinopsis atramentaria extract,its organic acids,and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents[J].Food Funct,2014,5(10):2521-2528.
[86]	RUAN X C,DENG X L,TAN M L,et al.In vitro antibiofilm activity of resveratrol against avian pathogenic Escherichia coli[J].BMC Vet Res,2021,17(1):249.
[87]	VIDIGAL P G,MVSKEN M,BECKER K A,et al.Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm[J].PLoS One,2014,9(4):e92876.
[88]	杨慧,曲也直,高雅然,等.植物多酚-蛋白质复合物生物活性及应用研究进展[J].食品科学,2022,43(3):258-266.YANG H,QU Y Z,GAO Y R,et al.Recent advances in understanding the biological activities and applications of polyphenol-protein complexes[J].Food Science,2022,43(3):258-266.(in Chinese)
[89]	SCALBERT A.Antimicrobial properties of tannins[J].Phytochemistry,1991,30(12):3875-3883.
[90]	AHMED N,EL-FATEH M,AMER M S,et al.Antioxidative and cytoprotective efficacy of ethanolic extracted cranberry pomace against Salmonella enteritidis infection in chicken liver cells[J].Antioxidants (Basel),2023,12(2):460.
[91]	MANNELLI F,MINIERI S,TOSI G,et al.Effect of chestnut tannins and short chain fatty acids as anti-microbials and as feeding supplements in broilers rearing and meat quality[J].Animals (Basel),2019,9(9):659.
[92]	SCICUTELLA F,MANNELLI F,DAGHIO M,et al.Polyphenols and organic acids as alternatives to antimicrobials in poultry rearing:a review[J].Antibiotics (Basel),2021,10(8):1010.
[93]	DAKHEEL M M,ALKANDARI F A H,MUELLER-HARVEY I,et al.Antimicrobial in vitro activities of condensed tannin extracts on avian pathogenic Escherichia coli[J].Lett Appl Microbiol,2020,70(3):165-172.
[94]	SIVASANKAR C,JHA N K,GHOSH R,et al.Anti quorum sensing and anti virulence activity of tannic acid and it’s potential to breach resistance in Salmonella enterica Typhi/Paratyphi A clinical isolates[J].Microb Pathog,2020,138:103813.
[95]	NAGAYAMA K,IWAMURA Y,SHIBATA T,et al.Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome[J].J Antimicrob Chemother,2002,50(6):889-893.
[96]	ERINLE T J,BOULIANNE M,ADEWOLE D.Red osier dogwood extract vs.trimethoprim-sulfadiazine (Part 2).Pharmacodynamic effects on ileal and cecal microbiota of broiler chickens challenged orally with Salmonella Enteritidis[J].Poult Sci,2023,102(4):102550.
[97]	黄深惠,汤有志,周雪梦,等.茶多酚体内外抗流感病毒作用研究[J].茶叶科学,2010,30(4):302-308.HUANG S H,TANG Y Z,ZHOU X M,et al.Study on anti-influenza virus effect of tea polyphenols in vitro and in vivo[J].Journal of Tea Science,2010,30(4):302-308.(in Chinese)
[98]	卫飞,凌佳馨,李宁,等.表没食子儿茶素没食子酸酯对甲型流感病毒致宿主细胞氧化应激损伤的影响[J].中国实验方剂学杂志,2012,18(24):212-216.WEI F,LING J X,LI N,et al.Protection in vitro of epigallocatechin gallate on oxidative stress induced by influenza infection[J].Chinese Journal of Experimental Traditional Medical Formulae,2012,18(24):212-216.(in Chinese)
[99]	金秀,姚站馨,郭长江,等.植物化学物抗病毒作用的研究进展[J].营养学报,2020,42(2):183-186,192.JIN X,YAO Z X,GUO C J,et al.Advances in research on antiviral effects of phytochemicals[J].Acta Nutrimenta Sinica,2020.42(2):183-186,192.(in Chinese)
[100]	ZHU Y Q,GU X X,ZHANG M,et al.Epigallocatechin-3-gallate exhibits antiviral effects against the duck Tembusu virus via blocking virus entry and upregulating type I interferons[J].Poult Sci,2021,100(4):100989.
[101]	ABAIDULLAH M,PENG S W,SONG X,et al.Chlorogenic acid is a positive regulator of MDA5,TLR7 and NF-κB signaling pathways mediated antiviral responses against Gammacoronavirus infection[J].Int Immunopharmacol,2021,96:107671.
[102]	LI Y J,YANG D F,JIA Y Y,et al.Research Note:anti-inflammatory effects and antiviral activities of baicalein and chlorogenic acid against infectious bursal disease virus in embryonic eggs[J].Poult Sci,2021,100(4):100987.
[103]	LEE H J,LEE Y N,YOUN H N,et al.Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens[J].Poult Sci,2012,91(1):66-73.
[104]	GRILLI G,BORGONOVO F,TULLO E,et al.A pilot study to detect coccidiosis in poultry farms at early stage from air analysis[J].Biosyst Eng,2018,173:64-70.
[105]	蔡海莹,汪丽伟,徐晓娟,等.茶多酚抗柔嫩艾美尔球虫的效果及作用机制[J].中国兽医学报,2014,34(3):427-430,470.CAI H Y,WANG L W,XU X J,et al.Effect of tea polyphenol on anti-Eimeria tenella[J].Chinese Journal of Veterinary Science,2014,34(3):427-430,470.(in Chinese)
[106]	刘雪,杜叶叶,李涛,等.饲料添加剂对感染球虫肉鸡早期肠道健康的影响[J].中国农业大学学报,2018,23(11):80-87.LIU X,DU Y Y,LI T,et al.Effects of feed additives on the intestinal health of broilers during the early period of coccidial infection[J].Journal of China Agricultural University,2018,23(11):80-87.(in Chinese)
[107]	李登辉.茶多酚对感染球虫肉鸡肠道微生态影响及其作用机理研究[D].合肥:安徽农业大学,2015.LI D H.The influence of tea polyphenol on the intestinal microecology of broiler by Eimeria challenge[D].Hefei:Anhui Agricultural University,2015.(in Chinese)
[108]	TONDA R M,RUBACH J K,LUMPKINS B S,et al.Effects of tannic acid extract on performance and intestinal health of broiler chickens following coccidiosis vaccination and/or a mixed-species Eimeria challenge[J].Poult Sci,2018,97(9):3031-3042.
[109]	MANSOORI B,MODIRSANEI M.Effects of dietary tannic acid and vaccination on the course of coccidiosis in experimentally challenged broiler chicken[J].Vet Parasitol,2012,187(1-2):119-122.