甲状腺激素受体基因调控动物繁殖的研究进展

doi:10.11843/j.issn.0366-6964.2019.02.002

畜牧兽医学报 ›› 2019, Vol. 50 ›› Issue (2): 243-252.doi: 10.11843/j.issn.0366-6964.2019.02.002

甲状腺激素受体基因调控动物繁殖的研究进展

李华振^1,2, 刘武军², 刘秋月¹, 王翔宇¹, 胡文萍¹, 夏青¹, 李春艳¹, 贺小云¹, 狄冉^1*, 储明星^1*

1. 中国农业科学院北京畜牧兽医研究所, 农业部动物遗传育种与繁殖重点实验室, 北京 100193;
2. 新疆农业大学动物科学学院, 乌鲁木齐 830052

收稿日期:2018-04-11 出版日期:2019-02-23 发布日期:2019-02-23
通讯作者: 狄冉,主要从事动物分子育种研究,E-mail:dirangirl@163.com;储明星,主要从事羊优异繁殖性状的分子机理研究,E-mail:mxchu@263.net
作者简介:李华振(1992-),男,新疆玛纳斯人,硕士生,主要从事动物分子育种研究,E-mail:1078728382@qq.com;刘武军(1966-),女,教授,博士,博士生导师,主要从事分子遗传学、反刍动物生产研究。
基金资助:
国家自然科学基金（31572371）；国家转基因科技重大专项（2016ZX08009-003-006；2016ZX08010-005-003）；国家肉羊产业技术体系专项（CARS-38）；中央级公益性科研院所基本科研业务费专项（Y2017JC24；2017ywf-zd-13）；中国农业科学院科技创新工程（ASTIP-IAS13；CAAS-XTCX2016010-01-03；CAAS-XTCX2016010-03-03；CAAS-XTCX2016011-02-02）；宁夏农林科学院科技创新先导资金项目（DWJLC-2016001）；内蒙古自治区科技重大专项；农业科研杰出人才及其创新团队项目；国家万人计划科技创新领军人才项目；天津市农业科技成果转化与推广项目（201704020）

Research Progress on the Regulative Role of Thyroid Hormone Receptor Gene in Animal Reproduction

LI Huazhen^1,2, LIU Wujun², LIU Qiuyue¹, WANG Xiangyu¹, HU Wenping¹, XIA Qing¹, LI Chunyan¹, HE Xiaoyun¹, DI Ran^1*, CHU Mingxing^1*

1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China

Received:2018-04-11 Online:2019-02-23 Published:2019-02-23

摘要/Abstract

摘要：

甲状腺激素（thyroid hormone，TH）及其受体除了参与调控机体正常发育和代谢平衡外，还在动物繁殖活动中发挥重要的生物学作用。甲状腺激素受体α（thyroid hormone receptor alpha，TRα）和甲状腺激素受体β（thyroid hormone receptor beta，TRβ）属于配体依赖性核受体超家族成员，分别由THRA和THRB两个基因编码，这两个基因的选择性剪接或转录起始位置不同可导致不同组织中存在多种受体亚型。本文首先介绍了TRs的基本特征；然后以下丘脑-垂体-性腺轴（hypothalamic-pituitary-gonadal axis，HPGA）为主线，综述了TRs通过参与促性腺激素释放激素（gonadotropin-releasing hormone，GnRH）脉冲释放、促性腺激素水平、促性腺激素受体和性激素受体的表达实现对性腺轴系统的繁殖调控；最后，从TH-GnRH通路、TH/TRs在哺乳动物季节性繁殖中的作用及在鸟类季节性繁殖中的作用3个方面概述了TH/TRs对动物季节性繁殖的调控作用，有助于深入了解动物季节性繁殖的分子机制，为季节性发情的人工调控提供新思路。

Abstract:

Thyroid hormone (TH) and its receptors play an important biological role in animal reproduction, in addition to regulating normal body development and metabolic balance. Thyroid hormone receptor alpha (TRα) and thyroid hormone receptor beta (TRβ) belong to the ligand-dependent nuclear receptor superfamily and are encoded by the THRA and THRB genes, respectively. Different alternative splicing or transcription start positions in the 2 genes can result in multiple receptor subtypes in different tissues. In this review, the basic characteristics of TRs were introduced firstly. Then using the hypothalamic-pituitary-gonadal axis (HPGA) as a clue, the regulation of TRs on the gonadal axis system by involving pulse release of gonadotropin-releasing hormone (GnRH), levels of gonadal hormones, gonadotropin receptor and sex hormone receptor expression was reviewed. Finally, this review summarizes the regulation of TH/TRs on seasonal reproduction from aspects of TH-GnRH pathway, the role of TH/TRs in seasonal reproduction of mammals and their role in seasonal bird reproduction in favor of understanding the molecular mechanism of seasonal reproduction of animals and providing new ideas for artificial regulation of seasonal estrus.

中图分类号:

S814

李华振, 刘武军, 刘秋月, 王翔宇, 胡文萍, 夏青, 李春艳, 贺小云, 狄冉, 储明星. 甲状腺激素受体基因调控动物繁殖的研究进展[J]. 畜牧兽医学报, 2019, 50(2): 243-252.

LI Huazhen, LIU Wujun, LIU Qiuyue, WANG Xiangyu, HU Wenping, XIA Qing, LI Chunyan, HE Xiaoyun, DI Ran, CHU Mingxing. Research Progress on the Regulative Role of Thyroid Hormone Receptor Gene in Animal Reproduction[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(2): 243-252.

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甲状腺激素受体基因调控动物繁殖的研究进展

Research Progress on the Regulative Role of Thyroid Hormone Receptor Gene in Animal Reproduction

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